| Protein: | pmk-3 |
| Organism: | Caenorhabditis elegans |
| Length: | 474 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for pmk-3.
| Description | E-value | Query Range |
Subject Range |
|
|
368.0 | [0..14] | [474..14] |
|
Region A: Residues: [1-404] |
1 11 21 31 41 51
| | | | | |
1 MASVPSSSSL PVSHVRRHED VSTPSAPPTK RSNNQSQPPE SYEPNTWLQQ QREQEQQKKL 60
61 AAENIKKQSI EATGNNEMVG EEEEDILSKP CGPHKRRFQF VMIRNITFAI PEGYDVEPNS 120
121 IEYLGGGSFG NVIKTSAVCR DGLRRYVAIK KMREPFFDPH HARRIFRETK LLQLMRHDNI 180
181 ICALDIYTPD EENDFRDVYV VTEFAGRSLY QILKQQRDYG RRVLTDEHIK FIIYQIIRAL 240
241 KYIHSANIIH RDLKPGNLAL TDDSDLMILD FGLARSLEKK DTSLTQYVQT RWYRSPEVIY 300
301 WKIDSYTNLA DMWSLGCIAA ELLTGEPLFP GDEPNAQYQR ITQLCGSPDE ELLTKIENDN 360
361 SSAIKAVIQS YTTHKRRNFR DVFSAHNPSE DFIDLLEKLL VLDP
|
| Detection Method: |  |
| Confidence: | 46.69897 |
| Match: | 1opkA |
| Description: | Abl tyrosine kinase, SH3 domain; Abl tyrosine kinase; Abelsone tyrosine kinase (abl) |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| acetylcholine receptor activator activity | 5.9159846946654 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 5.68265749805481 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 5.49988294224815 | bayes_pls_golite062009 |
| protein kinase activity | 5.4586557943719 | bayes_pls_golite062009 |
| kinase activity | 5.3287080791198 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 4.96052051118534 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase activity | 4.62392503670521 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 4.46381887831481 | bayes_pls_golite062009 |
| calmodulin-dependent protein kinase activity | 4.31938467136214 | bayes_pls_golite062009 |
| transferase activity | 3.97138602499442 | bayes_pls_golite062009 |
| structural molecule activity | 3.82327979736517 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 3.41480681854114 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 3.40140621607334 | bayes_pls_golite062009 |
| MAP kinase 2 activity | 3.27009208121248 | bayes_pls_golite062009 |
| protein tyrosine kinase activity | 2.8153155526437 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 2.79505438761262 | bayes_pls_golite062009 |
| binding | 2.74863538127007 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase regulator activity | 2.68482590086393 | bayes_pls_golite062009 |
| transmembrane receptor activity | 2.59526003830791 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 2.52531786618214 | bayes_pls_golite062009 |
| inositol or phosphatidylinositol phosphodiesterase activity | 2.50158263483669 | bayes_pls_golite062009 |
| phosphoinositide phospholipase C activity | 2.50158263483669 | bayes_pls_golite062009 |
| cation transmembrane transporter activity | 2.46424348876434 | bayes_pls_golite062009 |
| signal transducer activity | 2.40586892801446 | bayes_pls_golite062009 |
| molecular transducer activity | 2.40586892801446 | bayes_pls_golite062009 |
| receptor activity | 2.39311927684508 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 2.37122853419919 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase activity | 2.30873410607588 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity | 2.30873410607588 | bayes_pls_golite062009 |
| histone kinase activity (H3-S10 specific) | 2.30449166929476 | bayes_pls_golite062009 |
| protein binding | 2.276111749106 | bayes_pls_golite062009 |
| tubulin binding | 2.18641675163967 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 2.12615078788254 | bayes_pls_golite062009 |
| receptor signaling protein activity | 2.10379226653669 | bayes_pls_golite062009 |
| ATP binding | 1.97600611746091 | bayes_pls_golite062009 |
| ubiquitin-protein ligase activity | 1.94085498993561 | bayes_pls_golite062009 |
| adenyl ribonucleotide binding | 1.93596671856664 | bayes_pls_golite062009 |
| adenyl nucleotide binding | 1.90928021591891 | bayes_pls_golite062009 |
| metal ion transmembrane transporter activity | 1.9016235206634 | bayes_pls_golite062009 |
| microtubule binding | 1.88110801192607 | bayes_pls_golite062009 |
| actin binding | 1.87817875565699 | bayes_pls_golite062009 |
| receptor signaling protein serine/threonine kinase activity | 1.81249386965144 | bayes_pls_golite062009 |
| molecular adaptor activity | 1.81145713371725 | bayes_pls_golite062009 |
| telethonin binding | 1.75733591474207 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity, type I | 1.74645334586495 | bayes_pls_golite062009 |
| small conjugating protein ligase activity | 1.74206248731815 | bayes_pls_golite062009 |
| activin binding | 1.69795678545106 | bayes_pls_golite062009 |
| fibroblast growth factor 1 binding | 1.66976264488423 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 1.65732943334212 | bayes_pls_golite062009 |
| ribonucleotide binding | 1.65726906484847 | bayes_pls_golite062009 |
| activin receptor activity | 1.64506335968643 | bayes_pls_golite062009 |
| purine nucleotide binding | 1.63763394711025 | bayes_pls_golite062009 |
| nucleotide binding | 1.63195828048121 | bayes_pls_golite062009 |
| insulin receptor substrate binding | 1.62657794525303 | bayes_pls_golite062009 |
| JUN kinase kinase kinase activity | 1.60259443694567 | bayes_pls_golite062009 |
| SH3/SH2 adaptor activity | 1.59474164216385 | bayes_pls_golite062009 |
| transcription regulator activity | 1.56748951434625 | bayes_pls_golite062009 |
| growth factor binding | 1.53863828216563 | bayes_pls_golite062009 |
| nucleic acid binding | 1.46547714006072 | bayes_pls_golite062009 |
| MAP kinase kinase activity | 1.42275431028856 | bayes_pls_golite062009 |
| DNA binding | 1.35333135345112 | bayes_pls_golite062009 |
| ErbB-3 class receptor binding | 1.34841233233438 | bayes_pls_golite062009 |
| ErbB-2 class receptor binding | 1.33825339298024 | bayes_pls_golite062009 |
| kinase binding | 1.26086833316556 | bayes_pls_golite062009 |
| epidermal growth factor receptor binding | 1.24312972088703 | bayes_pls_golite062009 |
| acid-amino acid ligase activity | 1.2266791546014 | bayes_pls_golite062009 |
| catalytic activity | 1.21655087018101 | bayes_pls_golite062009 |
| transcription elongation regulator activity | 1.16995153203536 | bayes_pls_golite062009 |
| transcription repressor activity | 1.14496167267281 | bayes_pls_golite062009 |
| transporter activity | 1.11833481501707 | bayes_pls_golite062009 |
| non-membrane spanning protein tyrosine kinase activity | 1.11664317075762 | bayes_pls_golite062009 |
| transcription factor activity | 1.10928254946881 | bayes_pls_golite062009 |
| vinculin binding | 1.06656350652527 | bayes_pls_golite062009 |
| protein kinase binding | 1.06030596516506 | bayes_pls_golite062009 |
| cation channel activity | 1.04999722123563 | bayes_pls_golite062009 |
| type II transforming growth factor beta receptor binding | 1.03605423743048 | bayes_pls_golite062009 |
| SMAD binding | 1.02108562119195 | bayes_pls_golite062009 |
| transcription activator activity | 0.997272622653026 | bayes_pls_golite062009 |
| PTB domain binding | 0.9900774724568 | bayes_pls_golite062009 |
| transmembrane transporter activity | 0.97575992765505 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 0.925299895386908 | bayes_pls_golite062009 |
| alpha-actinin binding | 0.877087652539674 | bayes_pls_golite062009 |
| insulin-like growth factor receptor binding | 0.872782211382796 | bayes_pls_golite062009 |
| fibroblast growth factor binding | 0.870666814073948 | bayes_pls_golite062009 |
| protein binding, bridging | 0.83823250804321 | bayes_pls_golite062009 |
| activin receptor activity, type I | 0.82317428935631 | bayes_pls_golite062009 |
| MAP kinase activity | 0.81943579965027 | bayes_pls_golite062009 |
| actin filament binding | 0.794152600084 | bayes_pls_golite062009 |
| fibroblast growth factor receptor activity | 0.75189004129952 | bayes_pls_golite062009 |
| receptor serine/threonine kinase binding | 0.728917900114111 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.705905455086486 | bayes_pls_golite062009 |
| transforming growth factor beta receptor binding | 0.705634826374884 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase binding | 0.705634826374884 | bayes_pls_golite062009 |
| hormone receptor binding | 0.705067960165986 | bayes_pls_golite062009 |
| beta-catenin binding | 0.693246095477001 | bayes_pls_golite062009 |
| structural constituent of cytoskeleton | 0.612883428421652 | bayes_pls_golite062009 |
| JUN kinase kinase kinase kinase activity | 0.546647574638943 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase activating kinase activity | 0.529121666062889 | bayes_pls_golite062009 |
| steroid hormone receptor binding | 0.505233004492768 | bayes_pls_golite062009 |
| protein serine/threonine/tyrosine kinase activity | 0.48345772948903 | bayes_pls_golite062009 |
| enzyme binding | 0.46284745266176 | bayes_pls_golite062009 |
| transforming growth factor beta binding | 0.435457844706269 | bayes_pls_golite062009 |
| protein kinase C activity | 0.41587987561486 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase regulator activity | 0.406297251827056 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 0.401250804041384 | bayes_pls_golite062009 |
| structural constituent of muscle | 0.399773397398032 | bayes_pls_golite062009 |
| magnesium ion binding | 0.393328812780268 | bayes_pls_golite062009 |
| MAP kinase kinase kinase activity | 0.37115026509016 | bayes_pls_golite062009 |
| JUN kinase kinase activity | 0.332372116912461 | bayes_pls_golite062009 |
| structure-specific DNA binding | 0.318153468064373 | bayes_pls_golite062009 |
| phosphotyrosine binding | 0.311079584914389 | bayes_pls_golite062009 |
| channel activity | 0.287189255116606 | bayes_pls_golite062009 |
| passive transmembrane transporter activity | 0.287189255116606 | bayes_pls_golite062009 |
| insulin receptor binding | 0.266450215230107 | bayes_pls_golite062009 |
| substrate-specific channel activity | 0.261869836686301 | bayes_pls_golite062009 |
| RNA binding | 0.245748631571068 | bayes_pls_golite062009 |
| phosphoric diester hydrolase activity | 0.242965929129671 | bayes_pls_golite062009 |
| ion channel activity | 0.241519346930618 | bayes_pls_golite062009 |
| nuclear hormone receptor binding | 0.240883589532225 | bayes_pls_golite062009 |
| protein complex binding | 0.239339759110451 | bayes_pls_golite062009 |
| insulin receptor activity | 0.237134032032089 | bayes_pls_golite062009 |
| SH2 domain binding | 0.226760162354251 | bayes_pls_golite062009 |
| peptide binding | 0.118578378753757 | bayes_pls_golite062009 |
| brain-derived neurotrophic factor binding | 0.0794053647730006 | bayes_pls_golite062009 |
| nitric-oxide synthase regulator activity | 0.00407218246327123 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 0.0040394359628233 | bayes_pls_golite062009 |
|
Region A: Residues: [405-474] |
1 11 21 31 41 51
| | | | | |
1 EKRITVEEAI QHPYLAEFSL PEDEPRADHI FDLDDSQART RFEWRDAVWK EIMNYKRLSS 60
61 SPLIPGEADR
|
| Detection Method: | |
| Confidence: | 89.09691 |
| Match: | 1zzlA |
| Description: | Crystal structure of P38 with triazolopyridine |
Matching Structure (courtesy of the PDB): |
|
