| Protein: | jnk-1 |
| Organism: | Caenorhabditis elegans |
| Length: | 463 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for jnk-1.
| Description | E-value | Query Range |
Subject Range |
|
|
414.0 | [0..1] | [463..1] |
|
Region A: Residues: [1-100] |
1 11 21 31 41 51
| | | | | |
1 MEERLSTTSS YPSHPGRSVE EDHNTLLASS SISSIIRGTR GHLNNFIESV GNWLVPSSSG 60
61 RDDDAVSLDS CQSVYSPVRH HINSGTGGGI LMEPSSIHVP
|
| Detection Method: |  |
| Confidence: | 53.045757 |
| Match: | 2fo0A |
| Description: | No description for 2fo0A was found. |
| Term | Confidence | Notes |
| structural molecule activity | 4.92879644055393 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 4.41722924924158 | bayes_pls_golite062009 |
| actin binding | 3.91045208670052 | bayes_pls_golite062009 |
| protein binding | 3.13677730481089 | bayes_pls_golite062009 |
| binding | 3.06905798270146 | bayes_pls_golite062009 |
| actin filament binding | 2.72908433443928 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 2.65451266834284 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 2.4913932444423 | bayes_pls_golite062009 |
| molecular transducer activity | 1.34867629228264 | bayes_pls_golite062009 |
| signal transducer activity | 1.34867629228264 | bayes_pls_golite062009 |
| transporter activity | 1.30447542854757 | bayes_pls_golite062009 |
| transmembrane transporter activity | 1.08558010881058 | bayes_pls_golite062009 |
| structural constituent of muscle | 1.07367112106045 | bayes_pls_golite062009 |
| vinculin binding | 1.06656350652527 | bayes_pls_golite062009 |
| insulin receptor binding | 1.02499153496761 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.820987609295422 | bayes_pls_golite062009 |
| structural constituent of cytoskeleton | 0.371928447183203 | bayes_pls_golite062009 |
| insulin receptor substrate binding | 0.30555304014394 | bayes_pls_golite062009 |
| receptor binding | 0.0742205785215131 | bayes_pls_golite062009 |
|
Region A: Residues: [101-463] |
1 11 21 31 41 51
| | | | | |
1 ENYYSVTIGE AQMVVLKRYQ NLRLIGSGAQ GIVCSAFDTV RNEQVAIKKL SRPFQNVTHA 60
61 KRAYRELKLM SLVNHKNIIG ILNCFTPQKK LDEFNDLYIV MELMDANLCQ VIQMDLDHER 120
121 LSYLLYQMLC GIRHLHSAGI IHRDLKPSNI VVRSDCTLKI LDFGLARTAI EAFMMTPYVV 180
181 TRYYRAPEVI LGMGYKENVD VWSIGCIFGE LIRGRVLFPG GDHIDQWTRI IEQLGTPDRS 240
241 FLERLQPTVR NYVENRPRYQ ATPFEVLFSD NMFPMTADSS RLTGAQARDL LSRMLVIDPE 300
301 RRISVDDALR HPYVNVWFDE IEVYAPPPLP YDHNMDVEQN VDSWREHIFR ELTDYARTHD 360
361 IYS
|
| Detection Method: | |
| Confidence: | 96.69897 |
| Match: | 1ukhA |
| Description: | Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125 |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| acetylcholine receptor activator activity | 5.9159846946654 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 5.68265749805481 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 5.49988294224815 | bayes_pls_golite062009 |
| protein kinase activity | 5.4586557943719 | bayes_pls_golite062009 |
| kinase activity | 5.3287080791198 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 4.96052051118534 | bayes_pls_golite062009 |
| transcription elongation regulator activity | 4.93646793786886 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase activity | 4.62392503670521 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 4.46381887831481 | bayes_pls_golite062009 |
| transferase activity | 3.97138602499442 | bayes_pls_golite062009 |
| structural molecule activity | 3.82327979736517 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 3.41480681854114 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 3.40140621607334 | bayes_pls_golite062009 |
| MAP kinase 2 activity | 3.27009208121248 | bayes_pls_golite062009 |
| protein tyrosine kinase activity | 2.8153155526437 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 2.79505438761262 | bayes_pls_golite062009 |
| binding | 2.74863538127007 | bayes_pls_golite062009 |
| transmembrane receptor activity | 2.59526003830791 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 2.52531786618214 | bayes_pls_golite062009 |
| cation transmembrane transporter activity | 2.46424348876434 | bayes_pls_golite062009 |
| signal transducer activity | 2.40586892801446 | bayes_pls_golite062009 |
| molecular transducer activity | 2.40586892801446 | bayes_pls_golite062009 |
| receptor activity | 2.39311927684508 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 2.37122853419919 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase activity | 2.30873410607588 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity | 2.30873410607588 | bayes_pls_golite062009 |
| histone kinase activity (H3-S10 specific) | 2.30449166929476 | bayes_pls_golite062009 |
| protein binding | 2.276111749106 | bayes_pls_golite062009 |
| tubulin binding | 2.18641675163967 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 2.12615078788254 | bayes_pls_golite062009 |
| receptor signaling protein activity | 2.10379226653669 | bayes_pls_golite062009 |
| actin-dependent ATPase activity | 2.04489973303783 | bayes_pls_golite062009 |
| ATP binding | 1.97600611746091 | bayes_pls_golite062009 |
| ubiquitin-protein ligase activity | 1.94085498993561 | bayes_pls_golite062009 |
| adenyl ribonucleotide binding | 1.93596671856664 | bayes_pls_golite062009 |
| adenyl nucleotide binding | 1.90928021591891 | bayes_pls_golite062009 |
| metal ion transmembrane transporter activity | 1.9016235206634 | bayes_pls_golite062009 |
| microtubule binding | 1.88110801192607 | bayes_pls_golite062009 |
| actin binding | 1.87817875565699 | bayes_pls_golite062009 |
| receptor signaling protein serine/threonine kinase activity | 1.81249386965144 | bayes_pls_golite062009 |
| telethonin binding | 1.75733591474207 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity, type I | 1.74645334586495 | bayes_pls_golite062009 |
| small conjugating protein ligase activity | 1.74206248731815 | bayes_pls_golite062009 |
| activin binding | 1.69795678545106 | bayes_pls_golite062009 |
| fibroblast growth factor 1 binding | 1.66976264488423 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 1.65732943334212 | bayes_pls_golite062009 |
| ribonucleotide binding | 1.65726906484847 | bayes_pls_golite062009 |
| activin receptor activity | 1.64506335968643 | bayes_pls_golite062009 |
| purine nucleotide binding | 1.63763394711025 | bayes_pls_golite062009 |
| nucleotide binding | 1.63195828048121 | bayes_pls_golite062009 |
| insulin receptor substrate binding | 1.62657794525303 | bayes_pls_golite062009 |
| JUN kinase kinase kinase activity | 1.60259443694567 | bayes_pls_golite062009 |
| transcription regulator activity | 1.56748951434625 | bayes_pls_golite062009 |
| growth factor binding | 1.53863828216563 | bayes_pls_golite062009 |
| nucleic acid binding | 1.46547714006072 | bayes_pls_golite062009 |
| MAP kinase kinase activity | 1.42275431028856 | bayes_pls_golite062009 |
| DNA binding | 1.35333135345112 | bayes_pls_golite062009 |
| ErbB-3 class receptor binding | 1.34841233233438 | bayes_pls_golite062009 |
| ErbB-2 class receptor binding | 1.33825339298024 | bayes_pls_golite062009 |
| kinase binding | 1.26086833316556 | bayes_pls_golite062009 |
| acid-amino acid ligase activity | 1.2266791546014 | bayes_pls_golite062009 |
| catalytic activity | 1.21655087018101 | bayes_pls_golite062009 |
| transcription repressor activity | 1.14496167267281 | bayes_pls_golite062009 |
| transporter activity | 1.11833481501707 | bayes_pls_golite062009 |
| non-membrane spanning protein tyrosine kinase activity | 1.11664317075762 | bayes_pls_golite062009 |
| transcription factor activity | 1.10928254946881 | bayes_pls_golite062009 |
| protein kinase binding | 1.06030596516506 | bayes_pls_golite062009 |
| cation channel activity | 1.04999722123563 | bayes_pls_golite062009 |
| type II transforming growth factor beta receptor binding | 1.03605423743048 | bayes_pls_golite062009 |
| SMAD binding | 1.02108562119195 | bayes_pls_golite062009 |
| transcription activator activity | 0.997272622653026 | bayes_pls_golite062009 |
| PTB domain binding | 0.9900774724568 | bayes_pls_golite062009 |
| transmembrane transporter activity | 0.97575992765505 | bayes_pls_golite062009 |
| alpha-actinin binding | 0.877087652539674 | bayes_pls_golite062009 |
| insulin-like growth factor receptor binding | 0.872782211382796 | bayes_pls_golite062009 |
| fibroblast growth factor binding | 0.870666814073948 | bayes_pls_golite062009 |
| activin receptor activity, type I | 0.82317428935631 | bayes_pls_golite062009 |
| MAP kinase activity | 0.81943579965027 | bayes_pls_golite062009 |
| actin filament binding | 0.794152600084 | bayes_pls_golite062009 |
| fibroblast growth factor receptor activity | 0.75189004129952 | bayes_pls_golite062009 |
| receptor serine/threonine kinase binding | 0.728917900114111 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.705905455086486 | bayes_pls_golite062009 |
| transforming growth factor beta receptor binding | 0.705634826374884 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase binding | 0.705634826374884 | bayes_pls_golite062009 |
| hormone receptor binding | 0.705067960165986 | bayes_pls_golite062009 |
| beta-catenin binding | 0.693246095477001 | bayes_pls_golite062009 |
| structural constituent of cytoskeleton | 0.612883428421652 | bayes_pls_golite062009 |
| JUN kinase kinase kinase kinase activity | 0.546647574638943 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase activating kinase activity | 0.529121666062889 | bayes_pls_golite062009 |
| steroid hormone receptor binding | 0.505233004492768 | bayes_pls_golite062009 |
| protein serine/threonine/tyrosine kinase activity | 0.48345772948903 | bayes_pls_golite062009 |
| enzyme binding | 0.46284745266176 | bayes_pls_golite062009 |
| transforming growth factor beta binding | 0.435457844706269 | bayes_pls_golite062009 |
| protein kinase C activity | 0.41587987561486 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase regulator activity | 0.406297251827056 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 0.401250804041384 | bayes_pls_golite062009 |
| structural constituent of muscle | 0.399773397398032 | bayes_pls_golite062009 |
| magnesium ion binding | 0.393328812780268 | bayes_pls_golite062009 |
| myosin light chain binding | 0.377312539693791 | bayes_pls_golite062009 |
| MAP kinase kinase kinase activity | 0.37115026509016 | bayes_pls_golite062009 |
| JUN kinase kinase activity | 0.332372116912461 | bayes_pls_golite062009 |
| structure-specific DNA binding | 0.318153468064373 | bayes_pls_golite062009 |
| channel activity | 0.287189255116606 | bayes_pls_golite062009 |
| passive transmembrane transporter activity | 0.287189255116606 | bayes_pls_golite062009 |
| insulin receptor binding | 0.266450215230107 | bayes_pls_golite062009 |
| substrate-specific channel activity | 0.261869836686301 | bayes_pls_golite062009 |
| RNA binding | 0.245748631571068 | bayes_pls_golite062009 |
| ion channel activity | 0.241519346930618 | bayes_pls_golite062009 |
| nuclear hormone receptor binding | 0.240883589532225 | bayes_pls_golite062009 |
| protein complex binding | 0.239339759110451 | bayes_pls_golite062009 |
| insulin receptor activity | 0.237134032032089 | bayes_pls_golite062009 |
| SH2 domain binding | 0.226760162354251 | bayes_pls_golite062009 |
| ligase activity, forming carbon-oxygen bonds | 0.149958560815481 | bayes_pls_golite062009 |
| ligase activity, forming aminoacyl-tRNA and related compounds | 0.149958560815481 | bayes_pls_golite062009 |
| aminoacyl-tRNA ligase activity | 0.14842991990838 | bayes_pls_golite062009 |
| peptide binding | 0.118578378753757 | bayes_pls_golite062009 |
| brain-derived neurotrophic factor binding | 0.0794053647730006 | bayes_pls_golite062009 |
| nitric-oxide synthase regulator activity | 0.00407218246327123 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 0.0040394359628233 | bayes_pls_golite062009 |
