| Protein: | gi|62473051, gi|... |
| Organism: | Drosophila melanogaster |
| Length: | 2063 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|62473051, gi|....
| Description | E-value | Query Range |
Subject Range |
|
|
701.0 | [0..1] | [1694..1] |
|
Region A: Residues: [1-313] |
1 11 21 31 41 51
| | | | | |
1 MSNELSELIA LGCPDLAAQK PQGGSTQVEL ILNTERRLSI KQMTATDLAT LRAAAAAEAE 60
61 ARSRAQAEAE ALAIAQEQFR QAREAESKAR ARAALEVQAQ LQRVMESEKR RQQEEEERRI 120
121 RQQAEEEQED DEDDDNDEEE ELTKGSLPTN SGPRERIASL PCNIDDAMEM HLLNVSQPKA 180
181 SSKDDSPPKK STSHIADSIE LLRMQRAARD ARSHNRSRER SISPDRNRER SAAPDRLQSS 240
241 ASMSSLDSAS ASASRQPSKA GSRRGSTTSA TGVEPPLMAA PPQPTKFPLT KTVSAPNMDR 300
301 RRSSLTSLFP GPS
|
| Detection Method: |  |
| Confidence: | 31.09691 |
| Match: | 1i84S |
| Description: | Heavy meromyosin subfragment |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [314-474] |
1 11 21 31 41 51
| | | | | |
1 PLVAPEPSLH TNPDPRVQEQ IEEDRRRRRM DDGYREIPSG KMVHRTKTPP PVGTNLGVSL 60
61 KRVTAPSGSI TIKPKESPML GVVLRRVEKK TVPQKSILDD DKPLYHFSIV RSDHKEHVPA 120
121 QKPKPKPAPP AAKPSPGGIL TGPQVIRNAP KQPVPVKPQR P
|
| Detection Method: | |
| Confidence: | 4.0 |
| Match: | 2dm9A |
| Description: | No description for 2dm9A was found. |
|
Region A: Residues: [475-619] |
1 11 21 31 41 51
| | | | | |
1 MPGVPITITK IEGDKIIIIK KIIVPKNSKI PEQYLQVGRR RVGDRLVVSV VRLVFGVSFL 60
61 LCFVRNLFYR IYLDAPSPSL RTKEESQPAM QKPTPPPASG QQFFQVVSPQ FASVLSSSIP 120
121 ESKCAVRSPI SSPLAIRKSR PPLLP
|
| Detection Method: | |
| Confidence: | 18.221849 |
| Match: | 1uffA |
| Description: | Solution structure of the first SH3 domain of human intersectin2 (KIAA1256) |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| structural molecule activity | 4.92879644055393 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 4.41722924924158 | bayes_pls_golite062009 |
| actin binding | 3.91045208670052 | bayes_pls_golite062009 |
| protein binding | 3.13677730481089 | bayes_pls_golite062009 |
| binding | 3.06905798270146 | bayes_pls_golite062009 |
| actin filament binding | 2.72908433443928 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 2.65451266834284 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 2.4913932444423 | bayes_pls_golite062009 |
| molecular transducer activity | 1.34867629228264 | bayes_pls_golite062009 |
| signal transducer activity | 1.34867629228264 | bayes_pls_golite062009 |
| transporter activity | 1.30447542854757 | bayes_pls_golite062009 |
| transmembrane transporter activity | 1.08558010881058 | bayes_pls_golite062009 |
| structural constituent of muscle | 1.07367112106045 | bayes_pls_golite062009 |
| vinculin binding | 1.06656350652527 | bayes_pls_golite062009 |
| insulin receptor binding | 1.02499153496761 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.820987609295422 | bayes_pls_golite062009 |
| structural constituent of cytoskeleton | 0.371928447183203 | bayes_pls_golite062009 |
| insulin receptor substrate binding | 0.30555304014394 | bayes_pls_golite062009 |
| receptor binding | 0.0742205785215131 | bayes_pls_golite062009 |
|
Region A: Residues: [620-680] |
1 11 21 31 41 51
| | | | | |
1 SSPKSTPPLP RKHHPLAYNA ATGTISSASG AALPSRLMAT IASSPASSIS LSSCSSPSSS 60
61 P
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [681-879] |
1 11 21 31 41 51
| | | | | |
1 PPPVPCRAPK NASRPVAVTA APPPSTSNEI SLDKLLQQQQ ELEEKSAAAT NSAKMDANFY 60
61 DAEIEMMNKY LKSLPDYSEL DRKLHQEFQE CEDLYDKIKR QQQPLAKSNS QQSVTKAVGP 120
121 GVPAISSGLS KSSSINFAQN PSSRGAAPRL AYPSIFSQAA GEPKLQRSIS SSNMPISAPN 180
181 SMRPLPTKNG LQSGSNLSL
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [880-960] |
1 11 21 31 41 51
| | | | | |
1 NKQLMNEFWS ENLTSSQKRQ TPKRTFWNYE KICGAQLGDA GQPFKVDAKT AKKLAIFDPT 60
61 VAEAAQKELQ RPQQSQVPQN Q
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [961-1022] |
1 11 21 31 41 51
| | | | | |
1 PHKLQKNASL SHLDLKVRQA VTKDDLYKLI CNEQSPLAGS NFVSRVPVKQ QFPAQQQQVL 60
61 PK
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1023-1158] |
1 11 21 31 41 51
| | | | | |
1 SMSMTHVPGG GQPMGAPLLR TSSRTHIPSY MKNLPSLSRS TSNSAILMTQ PRKEPPPKEP 60
61 LKAPAPLPAI AAPTVGKPSG VLKSSSSSCV PSPRCAAAFF RRPQEANNPQ QQHHQPLQKP 120
121 QQVAPIEESG PGDSAS
|
| Detection Method: | |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1159-1401] |
1 11 21 31 41 51
| | | | | |
1 LERKSEKSNS TLSTSSFTVT NCCTTHLPQL SKFTSSFHIA PTTATTTAAT ATPTPTGAAT 60
61 TSDQQQQSGG TPAMVAANLE VPTSSSSSAA TKRQKDVDNK LEKCLNDMLK LKTSSNNNST 120
121 SNSNNNAIMS HSLTGEHKDP KTALEGPTSS SSSSSSKYIG ESQIPVPVQL YDPQKPLLQQ 180
181 QQQQQRICYP IGKSNSTSQL PMGGYQRLLQ HQQQQHHQQQ QQQHQEQQQY PQHKRPFLNW 240
241 NSF
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1402-1471] |
1 11 21 31 41 51
| | | | | |
1 ACSAMNGASD PFMQQQHMPA HQQQQHLPHK LQQSYSSSHV PKQAPKSGLA MFLQKNTNKE 60
61 NKFGQPMQQQ
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1472-1986] |
1 11 21 31 41 51
| | | | | |
1 PPGMMPQMYG YQAPQQQSKI GYPRTGAPLT HSASFSSAQR PTALQFHQQH QQQQHLQQQQ 60
61 QHPQQQQHQH SSFGVGMMSR NYYNMPKQPE RKPLQTFDPY AYPKPNQMQP VKYQQQQQHP 120
121 HTQFQNASAG GGGGGAAGLQ YDPNTNTQLF YASPASSSSN KQPQQPQQQQ QQQQSQLQQS 180
181 NSVIFNHSGQ QHQPHQQQQN EMSKSALGLH FIETAKPVIQ DDADGHLIYH TGDILHHRYK 240
241 IMATLGEGTF GRVVKVKDME RDYCMALKII KNVEKYREAA KLEINALEKI AQKDPHCDHL 300
301 CVKMIDWFDY HGHMCIVFEM LGLSVFDFLR ENNYEPYPLD QVRHMAYQLC YSVKFLHDNR 360
361 LTHTDLKPEN ILFVDSDYTS HYNHKINREV RRVKNTDVRL IDFGSATFDH EHHSTIVSTR 420
421 HYRAPEVILE LGWSQPCDVW SIGCILFELY LGITLFQTHD NREHLAMMER ILGQIPYRMA 480
481 RNHTLYSKTK TKYFYHGKLD WDEKSSAGRY VRDHC
|
| Detection Method: | |
| Confidence: | 57.154902 |
| Match: | 1opkA |
| Description: | Abl tyrosine kinase, SH3 domain; Abl tyrosine kinase; Abelsone tyrosine kinase (abl) |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| acetylcholine receptor activator activity | 5.9159846946654 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 5.68265749805481 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 5.49988294224815 | bayes_pls_golite062009 |
| protein kinase activity | 5.4586557943719 | bayes_pls_golite062009 |
| kinase activity | 5.3287080791198 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 4.96052051118534 | bayes_pls_golite062009 |
| transcription elongation regulator activity | 4.93646793786886 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase activity | 4.62392503670521 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 4.46381887831481 | bayes_pls_golite062009 |
| calmodulin-dependent protein kinase activity | 4.31938467136214 | bayes_pls_golite062009 |
| transferase activity | 3.97138602499442 | bayes_pls_golite062009 |
| structural molecule activity | 3.82327979736517 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 3.41480681854114 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 3.40140621607334 | bayes_pls_golite062009 |
| MAP kinase 2 activity | 3.27009208121248 | bayes_pls_golite062009 |
| protein tyrosine kinase activity | 2.8153155526437 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 2.79505438761262 | bayes_pls_golite062009 |
| binding | 2.74863538127007 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase regulator activity | 2.68482590086393 | bayes_pls_golite062009 |
| transmembrane receptor activity | 2.59526003830791 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 2.52531786618214 | bayes_pls_golite062009 |
| inositol or phosphatidylinositol phosphodiesterase activity | 2.50158263483669 | bayes_pls_golite062009 |
| phosphoinositide phospholipase C activity | 2.50158263483669 | bayes_pls_golite062009 |
| RNA binding | 2.47233810641059 | bayes_pls_golite062009 |
| cation transmembrane transporter activity | 2.46424348876434 | bayes_pls_golite062009 |
| signal transducer activity | 2.40586892801446 | bayes_pls_golite062009 |
| molecular transducer activity | 2.40586892801446 | bayes_pls_golite062009 |
| receptor activity | 2.39311927684508 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 2.37122853419919 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase activity | 2.30873410607588 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity | 2.30873410607588 | bayes_pls_golite062009 |
| histone kinase activity (H3-S10 specific) | 2.30449166929476 | bayes_pls_golite062009 |
| protein binding | 2.276111749106 | bayes_pls_golite062009 |
| tubulin binding | 2.18641675163967 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 2.12615078788254 | bayes_pls_golite062009 |
| receptor signaling protein activity | 2.10379226653669 | bayes_pls_golite062009 |
| ATP binding | 1.97600611746091 | bayes_pls_golite062009 |
| ubiquitin-protein ligase activity | 1.94085498993561 | bayes_pls_golite062009 |
| adenyl ribonucleotide binding | 1.93596671856664 | bayes_pls_golite062009 |
| adenyl nucleotide binding | 1.90928021591891 | bayes_pls_golite062009 |
| metal ion transmembrane transporter activity | 1.9016235206634 | bayes_pls_golite062009 |
| microtubule binding | 1.88110801192607 | bayes_pls_golite062009 |
| actin binding | 1.87817875565699 | bayes_pls_golite062009 |
| receptor signaling protein serine/threonine kinase activity | 1.81249386965144 | bayes_pls_golite062009 |
| molecular adaptor activity | 1.81145713371725 | bayes_pls_golite062009 |
| telethonin binding | 1.75733591474207 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity, type I | 1.74645334586495 | bayes_pls_golite062009 |
| small conjugating protein ligase activity | 1.74206248731815 | bayes_pls_golite062009 |
| activin binding | 1.69795678545106 | bayes_pls_golite062009 |
| fibroblast growth factor 1 binding | 1.66976264488423 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 1.65732943334212 | bayes_pls_golite062009 |
| ribonucleotide binding | 1.65726906484847 | bayes_pls_golite062009 |
| activin receptor activity | 1.64506335968643 | bayes_pls_golite062009 |
| purine nucleotide binding | 1.63763394711025 | bayes_pls_golite062009 |
| nucleotide binding | 1.63195828048121 | bayes_pls_golite062009 |
| insulin receptor substrate binding | 1.62657794525303 | bayes_pls_golite062009 |
| JUN kinase kinase kinase activity | 1.60259443694567 | bayes_pls_golite062009 |
| SH3/SH2 adaptor activity | 1.59474164216385 | bayes_pls_golite062009 |
| transcription regulator activity | 1.56748951434625 | bayes_pls_golite062009 |
| growth factor binding | 1.53863828216563 | bayes_pls_golite062009 |
| nucleic acid binding | 1.46547714006072 | bayes_pls_golite062009 |
| MAP kinase kinase activity | 1.42275431028856 | bayes_pls_golite062009 |
| DNA binding | 1.35333135345112 | bayes_pls_golite062009 |
| ErbB-3 class receptor binding | 1.34841233233438 | bayes_pls_golite062009 |
| ErbB-2 class receptor binding | 1.33825339298024 | bayes_pls_golite062009 |
| kinase binding | 1.26086833316556 | bayes_pls_golite062009 |
| epidermal growth factor receptor binding | 1.24312972088703 | bayes_pls_golite062009 |
| acid-amino acid ligase activity | 1.2266791546014 | bayes_pls_golite062009 |
| catalytic activity | 1.21655087018101 | bayes_pls_golite062009 |
| transcription repressor activity | 1.14496167267281 | bayes_pls_golite062009 |
| transporter activity | 1.11833481501707 | bayes_pls_golite062009 |
| non-membrane spanning protein tyrosine kinase activity | 1.11664317075762 | bayes_pls_golite062009 |
| transcription factor activity | 1.10928254946881 | bayes_pls_golite062009 |
| vinculin binding | 1.06656350652527 | bayes_pls_golite062009 |
| protein kinase binding | 1.06030596516506 | bayes_pls_golite062009 |
| cation channel activity | 1.04999722123563 | bayes_pls_golite062009 |
| type II transforming growth factor beta receptor binding | 1.03605423743048 | bayes_pls_golite062009 |
| SMAD binding | 1.02108562119195 | bayes_pls_golite062009 |
| transcription activator activity | 0.997272622653026 | bayes_pls_golite062009 |
| PTB domain binding | 0.9900774724568 | bayes_pls_golite062009 |
| transmembrane transporter activity | 0.97575992765505 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 0.925299895386908 | bayes_pls_golite062009 |
| alpha-actinin binding | 0.877087652539674 | bayes_pls_golite062009 |
| insulin-like growth factor receptor binding | 0.872782211382796 | bayes_pls_golite062009 |
| fibroblast growth factor binding | 0.870666814073948 | bayes_pls_golite062009 |
| protein binding, bridging | 0.83823250804321 | bayes_pls_golite062009 |
| activin receptor activity, type I | 0.82317428935631 | bayes_pls_golite062009 |
| MAP kinase activity | 0.81943579965027 | bayes_pls_golite062009 |
| actin filament binding | 0.794152600084 | bayes_pls_golite062009 |
| fibroblast growth factor receptor activity | 0.75189004129952 | bayes_pls_golite062009 |
| receptor serine/threonine kinase binding | 0.728917900114111 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.705905455086486 | bayes_pls_golite062009 |
| transforming growth factor beta receptor binding | 0.705634826374884 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase binding | 0.705634826374884 | bayes_pls_golite062009 |
| hormone receptor binding | 0.705067960165986 | bayes_pls_golite062009 |
| beta-catenin binding | 0.693246095477001 | bayes_pls_golite062009 |
| structural constituent of cytoskeleton | 0.612883428421652 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase activating kinase activity | 0.529121666062889 | bayes_pls_golite062009 |
| steroid hormone receptor binding | 0.505233004492768 | bayes_pls_golite062009 |
| protein serine/threonine/tyrosine kinase activity | 0.48345772948903 | bayes_pls_golite062009 |
| enzyme binding | 0.46284745266176 | bayes_pls_golite062009 |
| transforming growth factor beta binding | 0.435457844706269 | bayes_pls_golite062009 |
| protein kinase C activity | 0.41587987561486 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase regulator activity | 0.406297251827056 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 0.401250804041384 | bayes_pls_golite062009 |
| structural constituent of muscle | 0.399773397398032 | bayes_pls_golite062009 |
| magnesium ion binding | 0.393328812780268 | bayes_pls_golite062009 |
| MAP kinase kinase kinase activity | 0.37115026509016 | bayes_pls_golite062009 |
| structure-specific DNA binding | 0.318153468064373 | bayes_pls_golite062009 |
| phosphotyrosine binding | 0.311079584914389 | bayes_pls_golite062009 |
| channel activity | 0.287189255116606 | bayes_pls_golite062009 |
| passive transmembrane transporter activity | 0.287189255116606 | bayes_pls_golite062009 |
| insulin receptor binding | 0.266450215230107 | bayes_pls_golite062009 |
| substrate-specific channel activity | 0.261869836686301 | bayes_pls_golite062009 |
| ion channel activity | 0.241519346930618 | bayes_pls_golite062009 |
| nuclear hormone receptor binding | 0.240883589532225 | bayes_pls_golite062009 |
| protein complex binding | 0.239339759110451 | bayes_pls_golite062009 |
| insulin receptor activity | 0.237134032032089 | bayes_pls_golite062009 |
| SH2 domain binding | 0.226760162354251 | bayes_pls_golite062009 |
| peptide binding | 0.118578378753757 | bayes_pls_golite062009 |
| brain-derived neurotrophic factor binding | 0.0794053647730006 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 0.0040394359628233 | bayes_pls_golite062009 |
|
Region A: Residues: [1987-2063] |
1 11 21 31 41 51
| | | | | |
1 KPLFLCQLSD SEDHCELFSL IKKMLEYEPS SRITLGEALH HPFFDRLPPH HRVGEVSNKQ 60
61 PLSSGSSSRE RSHSLSR
|
| Detection Method: | |
| Confidence: | 2.7 |
| Match: | 2b9fA |
| Description: | Crystal structure of non-phosphorylated Fus3 |
Matching Structure (courtesy of the PDB): |
|
