| Protein: | InR-PB, InR-PC, ... |
| Organism: | Drosophila melanogaster |
| Length: | 2144 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for InR-PB, InR-PC, ....
| Description | E-value | Query Range |
Subject Range |
|
|
1403.0 | [0..1] | [2144..1] |
|
Region A: Residues: [1-130] |
1 11 21 31 41 51
| | | | | |
1 MFNMPRGVTK SKSKRGKIKM ENDMAAAATT TACTLGHICV LCRQEMLLDT CCCRQAVEAV 60
61 DSPASSEEAY SSSNSSSCQA SSEISAEEVW FLSHDDIVLC RRPKFDEVET TGKKRDVKCS 120
121 GHQCSNECDD
|
| Detection Method: |  |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [131-333] |
1 11 21 31 41 51
| | | | | |
1 GSTKNNRQQR ENFNIFSNCH NILRTLQSLL LLMFNCGIFN KRRRRQHQQQ HHHHYQHHHQ 60
61 QHHQQHHQRQ QANVSYTKFL LLLQTLAAAT TRLSLSPKNY KQQQQLQHNQ QLPRATPQQK 120
121 QQEKDRHKCF HYKHNYSYSP GISLLLFILL ANTLAIQAVV LPAHQQHLLH NDIADGLDKT 180
181 ALSVSGTQSR WTRSESNPTM RLS
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [334-1352] |
1 11 21 31 41 51
| | | | | |
1 QNVKPCKSMD IRNMVSHFNQ LENCTVIEGF LLIDLINDAS PLNRSFPKLT EVTDYIIIYR 60
61 VTGLHSLSKI FPNLSVIRGN KLFDGYALVV YSNFDLMDLG LHKLRSITRG GVRIEKNHKL 120
121 CYDRTIDWLE ILAENETQLV VLTENGKEKE CRLSKCPGEI RIEEGHDTTA IEGELNASCQ 180
181 LHNNRRLCWN SKLCQTKCPE KCRNNCIDEH TCCSQDCLGG CVIDKNGNES CISCRNVSFN 240
241 NICMDSCPKG YYQFDSRCVT ANECITLTKF ETNSVYSGIP YNGQCITHCP TGYQKSENKR 300
301 MCEPCPGGKC DKECSSGLID SLERAREFHG CTIITGTEPL TISIKRESGA HVMDELKYGL 360
361 AAVHKIQSSL MVHLTYGLKS LKFFQSLTEI SGDPPMDADK YALYVLDNRD LDELWGPNQT 420
421 VFIRKGGVFF HFNPKLCVST INQLLPMLAS KPKFFEKSDV GADSNGNRGS CGTAVLNVTL 480
481 QSVGANSAML NVTTKVEIGE PQKPSNATIV FKDPRAFIGF VFYHMIDPYG NSTKSSDDPC 540
541 DDRWKVSSPE KSGVMVLSNL IPYTNYSYYV RTMAISSELT NAESDVKNFR TNPGRPSKVT 600
601 EVVATAISDS KINVTWSYLD KPYGVLTRYF IKAKLINRPT RNNNRDYCTE PLVKAMENDL 660
661 PATTPTKKIS DPLAGDCKCV EGSKKTSSQE YDDRKVQAGM EFENALQNFI FVPNIRKSKN 720
721 GSSDKSDGAE GAALDSNAIP NGGATNPSRR RRDVALEPEL DDVEGSVLLR HVRSITDDTD 780
781 AFFEKDDENT YKDEEDLSSN KQFYEVFAKE LPPNQTHFVF EKLRHFTRYA IFVVACREEI 840
841 PSEKLRDTSF KKSLCSDYDT VFQTTKRKKF ADIVMDLKVD LEHANNTESP VRVRWTPPVD 900
901 PNGEIVTYEV AYKLQKPDQV EEKKCIPAAD FNQTAGYLIK LNEGLYSFRV RANSIAGYGD 960
961 FTEVEHIKVE PPPSYAKVFF WLLGIGLAFL IVSLFGYVCY LHKRKVPSND LHMNTEVNP
|
| Detection Method: | |
| Confidence: | 174.0 |
| Match: | 2dtgE |
| Description: | No description for 2dtgE was found. |
| Term | Confidence | Notes |
| PTB domain binding | 7.59954514905135 | bayes_pls_golite062009 |
| insulin-like growth factor II binding | 7.38215171153043 | bayes_pls_golite062009 |
| insulin-like growth factor binding | 6.22969465792364 | bayes_pls_golite062009 |
| cytokine receptor activity | 6.1064338595335 | bayes_pls_golite062009 |
| insulin-like growth factor I binding | 5.38913524516117 | bayes_pls_golite062009 |
| insulin receptor activity | 5.32497038633998 | bayes_pls_golite062009 |
| ciliary neurotrophic factor receptor activity | 5.11860004897785 | bayes_pls_golite062009 |
| interleukin-6 binding | 4.92289154730411 | bayes_pls_golite062009 |
| interleukin-6 receptor activity | 4.92289154730411 | bayes_pls_golite062009 |
| transmembrane receptor activity | 4.81256300373074 | bayes_pls_golite062009 |
| G-protein coupled receptor activity | 4.76090554940285 | bayes_pls_golite062009 |
| receptor activity | 4.66147271961356 | bayes_pls_golite062009 |
| prolactin receptor activity | 4.60875985371574 | bayes_pls_golite062009 |
| cytokine binding | 4.43581512268554 | bayes_pls_golite062009 |
| growth factor binding | 4.06808996928726 | bayes_pls_golite062009 |
| signal transducer activity | 3.69234048247377 | bayes_pls_golite062009 |
| molecular transducer activity | 3.69234048247377 | bayes_pls_golite062009 |
| phosphatase activator activity | 3.46731315564564 | bayes_pls_golite062009 |
| protein tyrosine phosphatase activator activity | 3.4533981235831 | bayes_pls_golite062009 |
| protein binding | 3.24522318184038 | bayes_pls_golite062009 |
| leukemia inhibitory factor receptor activity | 3.21526092940028 | bayes_pls_golite062009 |
| oncostatin-M receptor activity | 3.21526092940028 | bayes_pls_golite062009 |
| binding | 3.12471204223368 | bayes_pls_golite062009 |
| interleukin-11 binding | 3.02772247873413 | bayes_pls_golite062009 |
| interleukin-11 receptor activity | 3.02772247873413 | bayes_pls_golite062009 |
| SH2 domain binding | 3.02533711127154 | bayes_pls_golite062009 |
| peptide hormone binding | 3.00179150648816 | bayes_pls_golite062009 |
| ciliary neurotrophic factor receptor binding | 2.93858020991812 | bayes_pls_golite062009 |
| ciliary neurotrophic factor binding | 2.91569341552992 | bayes_pls_golite062009 |
| interleukin-2 binding | 2.68205932397612 | bayes_pls_golite062009 |
| receptor binding | 2.38673889309915 | bayes_pls_golite062009 |
| transcription regulator activity | 2.25224014924603 | bayes_pls_golite062009 |
| growth hormone receptor activity | 2.20449493522 | bayes_pls_golite062009 |
| cytokine receptor binding | 2.19283768224031 | bayes_pls_golite062009 |
| glycosaminoglycan binding | 2.18940962113822 | bayes_pls_golite062009 |
| nucleic acid binding | 2.13821456373219 | bayes_pls_golite062009 |
| peptide binding | 2.04467673245315 | bayes_pls_golite062009 |
| axon guidance receptor activity | 2.01367445237355 | bayes_pls_golite062009 |
| DNA binding | 1.95396591505956 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 1.91712452737778 | bayes_pls_golite062009 |
| integrin binding | 1.91458191628393 | bayes_pls_golite062009 |
| cytokine activity | 1.89256760974412 | bayes_pls_golite062009 |
| heparin binding | 1.8487779308526 | bayes_pls_golite062009 |
| transcription activator activity | 1.83493202330837 | bayes_pls_golite062009 |
| polysaccharide binding | 1.81113796966086 | bayes_pls_golite062009 |
| protein-hormone receptor activity | 1.79595098275141 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.61421027298524 | bayes_pls_golite062009 |
| interleukin-2 receptor activity | 1.59671474646742 | bayes_pls_golite062009 |
| kinase activity | 1.57994485110649 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.44501485815273 | bayes_pls_golite062009 |
| protein kinase activity | 1.42856560840953 | bayes_pls_golite062009 |
| insulin binding | 1.40490582483684 | bayes_pls_golite062009 |
| extracellular matrix structural constituent | 1.31280235604913 | bayes_pls_golite062009 |
| hormone binding | 1.31120662451488 | bayes_pls_golite062009 |
| transcription factor activity | 1.20939978283833 | bayes_pls_golite062009 |
| peptide receptor activity | 1.17841639726031 | bayes_pls_golite062009 |
| growth factor activity | 1.16355032792247 | bayes_pls_golite062009 |
| insulin-like growth factor receptor activity | 1.05533763659606 | bayes_pls_golite062009 |
| mercury ion binding | 1.02618624913674 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 1.02079990684516 | bayes_pls_golite062009 |
| protein dimerization activity | 0.86564366658585 | bayes_pls_golite062009 |
| actin filament binding | 0.848221254225135 | bayes_pls_golite062009 |
| fibroblast growth factor receptor binding | 0.784976995224461 | bayes_pls_golite062009 |
| interleukin-7 binding | 0.756988299000069 | bayes_pls_golite062009 |
| peptide receptor activity, G-protein coupled | 0.720863909999121 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 0.703490254739121 | bayes_pls_golite062009 |
| structural constituent of muscle | 0.68515307569834 | bayes_pls_golite062009 |
| kinase binding | 0.65927255037265 | bayes_pls_golite062009 |
| enzyme binding | 0.60195860585095 | bayes_pls_golite062009 |
| ankyrin binding | 0.56921114104552 | bayes_pls_golite062009 |
| identical protein binding | 0.564711394496051 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 0.554350228628563 | bayes_pls_golite062009 |
| peptidase activator activity | 0.47985796351505 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 0.46168925186147 | bayes_pls_golite062009 |
| epidermal growth factor receptor binding | 0.430075899423884 | bayes_pls_golite062009 |
| transcription factor binding | 0.428445565158989 | bayes_pls_golite062009 |
| glycoprotein binding | 0.41080910982871 | bayes_pls_golite062009 |
| protein kinase binding | 0.405060010394646 | bayes_pls_golite062009 |
| actin binding | 0.352053755111306 | bayes_pls_golite062009 |
| pattern binding | 0.31156427047296 | bayes_pls_golite062009 |
| nitric-oxide synthase regulator activity | 0.264724751323471 | bayes_pls_golite062009 |
| transcription cofactor activity | 0.211855991357483 | bayes_pls_golite062009 |
| structural molecule activity | 0.18965275490219 | bayes_pls_golite062009 |
| protein heterodimerization activity | 0.1430595594485 | bayes_pls_golite062009 |
| interleukin-12 binding | 0.12490373364175 | bayes_pls_golite062009 |
| protein homodimerization activity | 0.116391819218123 | bayes_pls_golite062009 |
| transcription coactivator activity | 0.05634414824449 | bayes_pls_golite062009 |
| protease binding | 0.0537311164268206 | bayes_pls_golite062009 |
|
Region A: Residues: [1353-1720] |
1 11 21 31 41 51
| | | | | |
1 FYASMQYIPD DWEVLRENII QLAPLGQGSF GMVYEGILKS FPPNGVDREC AIKTVNENAT 60
61 DRERTNFLSE ASVMKEFDTY HVVRLLGVCS RGQPALVVME LMKKGDLKSY LRAHRPEERD 120
121 EAMMTYLNRI GVTGNVQPPT YGRIYQMAIE IADGMAYLAA KKFVHRDLAA RNCMVADDLT 180
181 VKIGDFGMTR DIYETDYYRK GTKGLLPVRW MPPESLRDGV YSSASDVFSF GVVLWEMATL 240
241 AAQPYQGLSN EQVLRYVIDG GVMERPENCP DFLHKLMQRC WHHRSSARPS FLDIIAYLEP 300
301 QCPNSQFKEV SFYHSEAGLQ HREKERKERN QLDAFAAVPL DQDLQDREQQ EDATTPLRMG 360
361 DYQQNSSL
|
| Detection Method: | |
| Confidence: | 71.69897 |
| Match: | 1gagA |
| Description: | Insulin receptor |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| PTB domain binding | 8.10304453468842 | bayes_pls_golite062009 |
| insulin receptor activity | 6.0833679870912 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 5.49988294224815 | bayes_pls_golite062009 |
| protein kinase activity | 5.4586557943719 | bayes_pls_golite062009 |
| kinase activity | 5.3287080791198 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 4.96052051118534 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 4.46381887831481 | bayes_pls_golite062009 |
| fibroblast growth factor 1 binding | 4.09909681656699 | bayes_pls_golite062009 |
| stem cell factor receptor activity | 3.82614202737632 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 3.43994026029707 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase activity | 3.41480681854114 | bayes_pls_golite062009 |
| transmembrane receptor protein kinase activity | 3.40140621607334 | bayes_pls_golite062009 |
| receptor signaling protein serine/threonine kinase activity | 3.26784640416242 | bayes_pls_golite062009 |
| transmembrane receptor activity | 3.1965684217331 | bayes_pls_golite062009 |
| SH2 domain binding | 3.03401803018883 | bayes_pls_golite062009 |
| receptor activity | 2.96273889901429 | bayes_pls_golite062009 |
| signal transducer activity | 2.85730457922199 | bayes_pls_golite062009 |
| molecular transducer activity | 2.85730457922199 | bayes_pls_golite062009 |
| protein tyrosine kinase activity | 2.8153155526437 | bayes_pls_golite062009 |
| binding | 2.74863538127007 | bayes_pls_golite062009 |
| insulin-like growth factor II binding | 2.74473718307416 | bayes_pls_golite062009 |
| fibroblast growth factor receptor activity | 2.70917101514973 | bayes_pls_golite062009 |
| growth factor binding | 2.61235080252818 | bayes_pls_golite062009 |
| transferase activity | 2.34875558765742 | bayes_pls_golite062009 |
| protein binding | 2.276111749106 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity | 2.1677218320705 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase activity | 2.1677218320705 | bayes_pls_golite062009 |
| receptor signaling protein activity | 2.10379226653669 | bayes_pls_golite062009 |
| insulin binding | 2.0719180171079 | bayes_pls_golite062009 |
| ATP binding | 1.97600611746091 | bayes_pls_golite062009 |
| adenyl ribonucleotide binding | 1.93596671856664 | bayes_pls_golite062009 |
| adenyl nucleotide binding | 1.90928021591891 | bayes_pls_golite062009 |
| fibroblast growth factor binding | 1.9011085456623 | bayes_pls_golite062009 |
| non-membrane spanning protein tyrosine kinase activity | 1.66669268613198 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 1.65732943334212 | bayes_pls_golite062009 |
| ribonucleotide binding | 1.65726906484847 | bayes_pls_golite062009 |
| purine nucleotide binding | 1.63763394711025 | bayes_pls_golite062009 |
| nucleotide binding | 1.63195828048121 | bayes_pls_golite062009 |
| insulin receptor substrate binding | 1.62657794525303 | bayes_pls_golite062009 |
| transcription regulator activity | 1.56748951434625 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase activity | 1.5013287968167 | bayes_pls_golite062009 |
| nucleic acid binding | 1.46547714006072 | bayes_pls_golite062009 |
| integrin binding | 1.44154155381408 | bayes_pls_golite062009 |
| 1-phosphatidylinositol-3-kinase activity | 1.43713739644553 | bayes_pls_golite062009 |
| MAP kinase kinase activity | 1.42275431028856 | bayes_pls_golite062009 |
| DNA binding | 1.35333135345112 | bayes_pls_golite062009 |
| amine binding | 1.3051205627964 | bayes_pls_golite062009 |
| kinase binding | 1.26086833316556 | bayes_pls_golite062009 |
| ErbB-3 class receptor binding | 1.25765701903393 | bayes_pls_golite062009 |
| activin binding | 1.22461306010416 | bayes_pls_golite062009 |
| catalytic activity | 1.21655087018101 | bayes_pls_golite062009 |
| transporter activity | 1.11833481501707 | bayes_pls_golite062009 |
| transcription factor activity | 1.10928254946881 | bayes_pls_golite062009 |
| protein kinase binding | 1.06030596516506 | bayes_pls_golite062009 |
| transcription repressor activity | 1.00304216158732 | bayes_pls_golite062009 |
| receptor binding | 0.990272341309676 | bayes_pls_golite062009 |
| transmembrane transporter activity | 0.97575992765505 | bayes_pls_golite062009 |
| transcription activator activity | 0.955593006663586 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity, type I | 0.880236579821909 | bayes_pls_golite062009 |
| insulin-like growth factor receptor binding | 0.872782211382796 | bayes_pls_golite062009 |
| glycosaminoglycan binding | 0.867779574651545 | bayes_pls_golite062009 |
| insulin-like growth factor binding | 0.82854091092242 | bayes_pls_golite062009 |
| MAP kinase activity | 0.81943579965027 | bayes_pls_golite062009 |
| activin receptor activity | 0.811117252475389 | bayes_pls_golite062009 |
| platelet-derived growth factor receptor binding | 0.770658204347392 | bayes_pls_golite062009 |
| growth factor activity | 0.707777793848936 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.705905455086486 | bayes_pls_golite062009 |
| actin filament binding | 0.66248865719696 | bayes_pls_golite062009 |
| peptidase activity | 0.620684651690244 | bayes_pls_golite062009 |
| Janus kinase activity | 0.580310109637219 | bayes_pls_golite062009 |
| peptide binding | 0.560033905645957 | bayes_pls_golite062009 |
| ErbB-2 class receptor binding | 0.547121592096699 | bayes_pls_golite062009 |
| JUN kinase kinase kinase kinase activity | 0.546647574638943 | bayes_pls_golite062009 |
| cytokine receptor binding | 0.516151105278102 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase activity | 0.499492353295369 | bayes_pls_golite062009 |
| protein serine/threonine/tyrosine kinase activity | 0.48345772948903 | bayes_pls_golite062009 |
| enzyme binding | 0.46284745266176 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 0.450699332958421 | bayes_pls_golite062009 |
| peptidase activity, acting on L-amino acid peptides | 0.425716341891679 | bayes_pls_golite062009 |
| protein kinase C activity | 0.41587987561486 | bayes_pls_golite062009 |
| magnesium ion binding | 0.393328812780268 | bayes_pls_golite062009 |
| 3-phosphoinositide-dependent protein kinase binding | 0.372842462336059 | bayes_pls_golite062009 |
| MAP kinase kinase kinase activity | 0.37115026509016 | bayes_pls_golite062009 |
| polysaccharide binding | 0.344522125452779 | bayes_pls_golite062009 |
| heparin binding | 0.334438853447262 | bayes_pls_golite062009 |
| peptide hormone binding | 0.312169974523858 | bayes_pls_golite062009 |
| transforming growth factor beta binding | 0.287757704969289 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 0.284465446035567 | bayes_pls_golite062009 |
| insulin receptor binding | 0.266450215230107 | bayes_pls_golite062009 |
| protein complex binding | 0.239339759110451 | bayes_pls_golite062009 |
| cytokine binding | 0.17817111033393 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 0.148194101970458 | bayes_pls_golite062009 |
| actin binding | 0.144822861207099 | bayes_pls_golite062009 |
| activin receptor activity, type I | 0.117759584117941 | bayes_pls_golite062009 |
| endopeptidase activity | 0.0887520303124476 | bayes_pls_golite062009 |
| nitric-oxide synthase regulator activity | 0.00407218246327123 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 0.0040394359628233 | bayes_pls_golite062009 |
|
Region A: Residues: [1721-1948] |
1 11 21 31 41 51
| | | | | |
1 DQPPESPIAM VDDQGSHLPF SLPSGFIASS TPDGQTVMAT AFQNIPAAQG DISATYVVPD 60
61 ADALDGDRGY EIYDPSPKCA ELPTSRSGST GGGKLSGEQH LLPRKGRQPT IMSSSMPDDV 120
121 IGGSSLQPST ASAGSSNASS HTGRPSLKKT VADSVRNKAN FINRHLFNHK RTGSNASHKS 180
181 NASNAPSTSS NTNLTSHPVA MGNLGTIESG GSGSAGSYTG TPRFYTPS
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [1949-2144] |
1 11 21 31 41 51
| | | | | |
1 ATPGGGSGMA ISDNPNYRLL DESIASEQAT ILTTSSPNPN YEMMHPPTSL VSTNPNYMPM 60
61 NETPVQMAGV TISHNPNYQP MQAPLNARQS QSSSDEDNEQ EEDDEDEDDD VDDEHVEHIK 120
121 MERMPLSRPR QRALPSKTQP PRSRSVSQTR KSPTNPNSGI GATGAGNRSN LLKENWLRPA 180
181 STPRPPPPNG FIGREA
|
| Detection Method: | |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
