YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: AKT2
Organism: Homo sapiens
Length: 481 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AKT2.

Description E-value Query
Range		 Subject
Range
gi|109124742 - gi|109124742|ref|XP_001093024.1| PREDICTED: v-akt murine thymoma viral oncogene homolog 2 isoform 2 ...
 0.0 [1..481] [1..481]
gi|114677299 - gi|114677299|ref|XP_512662.2| PREDICTED: v-akt murine thymoma viral oncogene homolog 2 isoform 13 [P...
 0.0 [1..481] [1..481]
gi|149056511, gi... - gi|76365214|gb|ABA42095.1| protein kinase B beta [Rattus norvegicus], gi|149056513|gb|EDM07944.1| th...
 0.0 [1..481] [1..481]
gi|76641330 - gi|76641330|ref|XP_870006.1| PREDICTED: similar to RAC-beta serine/threonine-protein kinase (RAC-PK-...
 0.0 [1..481] [1..481]
gi|117616192 - gi|117616192|gb|ABK42114.1| Akt2 [synthetic construct]
AKT2_MOUSE - RAC-beta serine/threonine-protein kinase OS=Mus musculus GN=Akt2 PE=1 SV=1
 0.0 [1..481] [1..481]
gi|337491 - gi|337491|gb|AAA36585.1| rac protein kinase-beta [Homo sapiens]
 0.0 [1..481] [1..481]

Back

Predicted Domain #1
Region A:
Residues: [1-131] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNEVSVIKEG WLHKRGEYIK TWRPRYFLLK SDGSFIGYKE RPEAPDQTLP PLNNFSVAEC  60
   61 QLMKTERPRP NTFVIRCLQW TTVIERTFHV DSPDEREEWM RAIQMVANSL KQRAPGEDPM 120
  121 DYKCGSPSDS S

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.30103
Match: 1p6sA
Description: Solution Structure of the Pleckstrin Homology Domain of Human Protein Kinase B beta (Pkb/Akt)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
actin binding 3.72754591832642 bayes_pls_golite062009
cytoskeletal protein binding 3.48744511411671 bayes_pls_golite062009
insulin-like growth factor receptor binding 3.3707139031954 bayes_pls_golite062009
binding 3.29080729281876 bayes_pls_golite062009
protein binding 3.17213698546013 bayes_pls_golite062009
insulin receptor binding 2.87341016128079 bayes_pls_golite062009
phosphoinositide 3-kinase binding 2.84482185829578 bayes_pls_golite062009
profilin binding 2.77241328262501 bayes_pls_golite062009
actin filament binding 2.03444575838575 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.8384977631304 bayes_pls_golite062009
transcription regulator activity 1.70142823077711 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase signaling protein activity 1.56969272757764 bayes_pls_golite062009
molecular transducer activity 1.55319485371003 bayes_pls_golite062009
signal transducer activity 1.55319485371003 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.53043443218632 bayes_pls_golite062009
kinase activity 1.49733072352288 bayes_pls_golite062009
nucleic acid binding 1.45333553095537 bayes_pls_golite062009
DNA binding 1.44750105267972 bayes_pls_golite062009
SH2 domain binding 1.41526564231882 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.36365892826676 bayes_pls_golite062009
protein kinase activity 1.34246406302496 bayes_pls_golite062009
transporter activity 1.28986800087234 bayes_pls_golite062009
receptor activity 1.1755016270537 bayes_pls_golite062009
enzyme binding 1.17212675145623 bayes_pls_golite062009
phosphatidylinositol-3,4-bisphosphate binding 1.15025513961661 bayes_pls_golite062009
transmembrane receptor activity 1.1152029796159 bayes_pls_golite062009
phospholipid binding 1.09683218092034 bayes_pls_golite062009
Ran GTPase binding 1.07023555877478 bayes_pls_golite062009
transferase activity 1.05502123133116 bayes_pls_golite062009
receptor binding 1.00859318603128 bayes_pls_golite062009
receptor signaling protein activity 1.00400540041137 bayes_pls_golite062009
kinase binding 0.961706066143 bayes_pls_golite062009
protein domain specific binding 0.90578029954417 bayes_pls_golite062009
substrate-specific transporter activity 0.79883446648737 bayes_pls_golite062009
phosphoinositide binding 0.71817045430443 bayes_pls_golite062009
protein kinase binding 0.67284191028382 bayes_pls_golite062009
protein serine/threonine kinase activity 0.611829373978789 bayes_pls_golite062009
protein complex binding 0.55916857709427 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase docking protein activity 0.47238283185104 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.470521479239198 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.391864697086635 bayes_pls_golite062009
GTPase regulator activity 0.355387992614734 bayes_pls_golite062009
structural constituent of cytoskeleton 0.35466574267734 bayes_pls_golite062009
hydrolase activity 0.354215977182915 bayes_pls_golite062009
beta-amyloid binding 0.34714857141225 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.335498703113274 bayes_pls_golite062009
structural molecule activity 0.320527491838187 bayes_pls_golite062009
enzyme regulator activity 0.189879136353541 bayes_pls_golite062009
G-protein-coupled receptor binding 0.12466518799375 bayes_pls_golite062009
alpha-catenin binding 0.102004310679969 bayes_pls_golite062009
pyrophosphatase activity 0.0611639610381174 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0524559849408587 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0498422520006935 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [132-418] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTEEMEVAVS KARAKVTMND FDYLKLLGKG TFGKVILVRE KATGRYYAMK ILRKEVIIAK  60
   61 DEVAHTVTES RVLQNTRHPF LTALKYAFQT HDRLCFVMEY ANGGELFFHL SRERVFTEER 120
  121 ARFYGAEIVS ALEYLHSRDV VYRDIKLENL MLDKDGHIKI TDFGLCKEGI SDGATMKTFC 180
  181 GTPEYLAPEV LEDNDYGRAV DWWGLGVVMY EMMCGRLPFY NQDHERLFEL ILMEEIRFPR 240
  241 TLSPEAKSLL AGLLKKDPKQ RLGGGPSDAK EVMEHRFFLS INWQDVV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.045757
Match: 2j4zA
Description: No description for 2j4zA was found.

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
cyclic nucleotide-dependent protein kinase activity 4.97855712164511 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
cAMP-dependent protein kinase activity 4.66277812893755 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
calmodulin-dependent protein kinase activity 4.31938467136214 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 3.41480681854114 bayes_pls_golite062009
transmembrane receptor protein kinase activity 3.40140621607334 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
phosphoinositide 3-kinase binding 2.79505438761262 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
transmembrane receptor activity 2.59526003830791 bayes_pls_golite062009
ion transmembrane transporter activity 2.52531786618214 bayes_pls_golite062009
cation transmembrane transporter activity 2.46424348876434 bayes_pls_golite062009
molecular transducer activity 2.40586892801446 bayes_pls_golite062009
signal transducer activity 2.40586892801446 bayes_pls_golite062009
receptor activity 2.39311927684508 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.37122853419919 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.94085498993561 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
metal ion transmembrane transporter activity 1.9016235206634 bayes_pls_golite062009
actin binding 1.87817875565699 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
small conjugating protein ligase activity 1.74206248731815 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
insulin receptor substrate binding 1.62657794525303 bayes_pls_golite062009
JUN kinase kinase kinase kinase activity 1.55257528159541 bayes_pls_golite062009
growth factor binding 1.53863828216563 bayes_pls_golite062009
phosphoinositide 3-kinase activity 1.5013287968167 bayes_pls_golite062009
1-phosphatidylinositol-3-kinase activity 1.43713739644553 bayes_pls_golite062009
MAP kinase kinase activity 1.42275431028856 bayes_pls_golite062009
PTB domain binding 1.33588583294761 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.32254739984688 bayes_pls_golite062009
kinase binding 1.26086833316556 bayes_pls_golite062009
ErbB-3 class receptor binding 1.25765701903393 bayes_pls_golite062009
acid-amino acid ligase activity 1.2266791546014 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transcription regulator activity 1.16307073947901 bayes_pls_golite062009
type II transforming growth factor beta receptor binding 1.15601343883601 bayes_pls_golite062009
tubulin binding 1.13686658158825 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
transforming growth factor beta receptor activity 1.10045286406485 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 1.10045286406485 bayes_pls_golite062009
nucleic acid binding 1.06086848160606 bayes_pls_golite062009
protein kinase binding 1.06030596516506 bayes_pls_golite062009
cation channel activity 1.04999722123563 bayes_pls_golite062009
DNA binding 1.02122968429273 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.959360414036299 bayes_pls_golite062009
telethonin binding 0.953133636042811 bayes_pls_golite062009
insulin-like growth factor receptor binding 0.872782211382796 bayes_pls_golite062009
transcription factor activity 0.825932471558326 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
actin filament binding 0.794152600084 bayes_pls_golite062009
platelet-derived growth factor receptor binding 0.770658204347392 bayes_pls_golite062009
fibroblast growth factor receptor activity 0.75189004129952 bayes_pls_golite062009
transcription activator activity 0.746097961522136 bayes_pls_golite062009
microtubule binding 0.734274677384472 bayes_pls_golite062009
fibroblast growth factor binding 0.728507215600658 bayes_pls_golite062009
substrate-specific transporter activity 0.705905455086486 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
insulin receptor activity 0.585036697436369 bayes_pls_golite062009
transcription repressor activity 0.568332175782799 bayes_pls_golite062009
ErbB-2 class receptor binding 0.547121592096699 bayes_pls_golite062009
fibroblast growth factor 1 binding 0.537170519944039 bayes_pls_golite062009
activin binding 0.510364757301021 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
protein kinase C activity 0.41587987561486 bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity 0.406297251827056 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
passive transmembrane transporter activity 0.287189255116606 bayes_pls_golite062009
channel activity 0.287189255116606 bayes_pls_golite062009
insulin receptor binding 0.266450215230107 bayes_pls_golite062009
substrate-specific channel activity 0.261869836686301 bayes_pls_golite062009
ion channel activity 0.241519346930618 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
SH2 domain binding 0.226760162354251 bayes_pls_golite062009
insulin binding 0.147382876071569 bayes_pls_golite062009
peptide binding 0.118578378753757 bayes_pls_golite062009
alpha-actinin binding 0.0923798087054641 bayes_pls_golite062009
JUN kinase kinase kinase activity 0.0613131034808199 bayes_pls_golite062009
transforming growth factor beta receptor activity, type I 0.0506751594607393 bayes_pls_golite062009
MAP kinase kinase kinase kinase activity 0.01826424351081 bayes_pls_golite062009
nitric-oxide synthase regulator activity 0.00407218246327123 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [419-481] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QKKLLPPFKP QVTSEVDTRY FDDEFTAQSI TITPPDRYDS LGLLELDQRT HFPQFSYSAS  60
   61 IRE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 92.39794
Match: 1mrvA
Description: crystal structure of an inactive Akt2 kinase domain
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle