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View Structure Prediction Details

Protein: MCK1
Organism: Saccharomyces cerevisiae
Length: 375 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MCK1.

Description E-value Query
Range		 Subject
Range
MPK4_ARATH - Mitogen-activated protein kinase 4 OS=Arabidopsis thaliana GN=MPK4 PE=1 SV=2
 0.0 [12..372] [21..366]
MMK1_MEDSA - Mitogen-activated protein kinase homolog MMK1 OS=Medicago sativa GN=MMK1 PE=1 SV=1
 0.0 [11..374] [32..379]
NTF4_TOBAC - Mitogen-activated protein kinase homolog NTF4 OS=Nicotiana tabacum GN=NTF4 PE=2 SV=1
 0.0 [11..372] [37..382]
gi|7649153 - gi|7649153|gb|AAF65766.1|AF242308_1 mitogen-activated protein kinase [Euphorbia esula]
 0.0 [11..374] [33..380]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [2..372] [5..360]
MPK_PEA - Mitogen-activated protein kinase homolog D5 OS=Pisum sativum PE=2 SV=1
 0.0 [11..374] [39..386]

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Predicted Domain #1
Region A:
Residues: [1-117] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTEEQNGVP LQRGSEFIAD DVTSNKSNNT RRMLVKEYRK IGRGAFGTVV QAYLTQDKKN  60
   61 WLGPFAIKKV PAHTEYKSRE LQILRIADHP NIVKLQYFFT HLSPQDNKVY QHLAMEC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 811.9897
Match: 1i09A_
Description: Glycogen synthase kinase-3 beta (Gsk3b)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
acetylcholine receptor activator activity 5.9159846946654 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 5.68265749805481 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
cyclin-dependent protein kinase activity 4.62392503670521 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
structural molecule activity 3.82327979736517 bayes_pls_golite062009
phosphoinositide 3-kinase binding 3.43994026029707 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 3.41480681854114 bayes_pls_golite062009
transmembrane receptor protein kinase activity 3.40140621607334 bayes_pls_golite062009
SH2 domain binding 3.03401803018883 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
transmembrane receptor activity 2.59526003830791 bayes_pls_golite062009
ion transmembrane transporter activity 2.52531786618214 bayes_pls_golite062009
cation transmembrane transporter activity 2.46424348876434 bayes_pls_golite062009
signal transducer activity 2.40586892801446 bayes_pls_golite062009
molecular transducer activity 2.40586892801446 bayes_pls_golite062009
receptor activity 2.39311927684508 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.37122853419919 bayes_pls_golite062009
histone kinase activity (H3-S10 specific) 2.30449166929476 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.94085498993561 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
metal ion transmembrane transporter activity 1.9016235206634 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
actin binding 1.87817875565699 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
telethonin binding 1.75733591474207 bayes_pls_golite062009
small conjugating protein ligase activity 1.74206248731815 bayes_pls_golite062009
fibroblast growth factor 1 binding 1.66976264488423 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
insulin receptor substrate binding 1.62657794525303 bayes_pls_golite062009
PTB domain binding 1.61518967483617 bayes_pls_golite062009
JUN kinase kinase kinase activity 1.60259443694567 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
growth factor binding 1.53863828216563 bayes_pls_golite062009
nucleic acid binding 1.46547714006072 bayes_pls_golite062009
MAP kinase kinase activity 1.42275431028856 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
ErbB-3 class receptor binding 1.34841233233438 bayes_pls_golite062009
ErbB-2 class receptor binding 1.33825339298024 bayes_pls_golite062009
kinase binding 1.26086833316556 bayes_pls_golite062009
insulin binding 1.23861703046323 bayes_pls_golite062009
acid-amino acid ligase activity 1.2266791546014 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transcription elongation regulator activity 1.16995153203536 bayes_pls_golite062009
transcription repressor activity 1.14496167267281 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
non-membrane spanning protein tyrosine kinase activity 1.11664317075762 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 1.10045286406485 bayes_pls_golite062009
transforming growth factor beta receptor activity 1.10045286406485 bayes_pls_golite062009
protein kinase binding 1.06030596516506 bayes_pls_golite062009
cation channel activity 1.04999722123563 bayes_pls_golite062009
type II transforming growth factor beta receptor binding 1.03605423743048 bayes_pls_golite062009
transcription activator activity 0.997272622653026 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
alpha-actinin binding 0.877087652539674 bayes_pls_golite062009
insulin-like growth factor receptor binding 0.872782211382796 bayes_pls_golite062009
fibroblast growth factor binding 0.870666814073948 bayes_pls_golite062009
MAP kinase 2 activity 0.82135828535622 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
actin filament binding 0.794152600084 bayes_pls_golite062009
fibroblast growth factor receptor activity 0.75189004129952 bayes_pls_golite062009
substrate-specific transporter activity 0.705905455086486 bayes_pls_golite062009
hormone receptor binding 0.705067960165986 bayes_pls_golite062009
beta-catenin binding 0.693246095477001 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
JUN kinase kinase kinase kinase activity 0.546647574638943 bayes_pls_golite062009
cyclin-dependent protein kinase activating kinase activity 0.529121666062889 bayes_pls_golite062009
activin binding 0.510364757301021 bayes_pls_golite062009
steroid hormone receptor binding 0.505233004492768 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
brain-derived neurotrophic factor binding 0.462520151706601 bayes_pls_golite062009
protein kinase C activity 0.41587987561486 bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity 0.406297251827056 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.401250804041384 bayes_pls_golite062009
structural constituent of muscle 0.399773397398032 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
3-phosphoinositide-dependent protein kinase binding 0.372842462336059 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
JUN kinase kinase activity 0.332372116912461 bayes_pls_golite062009
structure-specific DNA binding 0.318153468064373 bayes_pls_golite062009
channel activity 0.287189255116606 bayes_pls_golite062009
passive transmembrane transporter activity 0.287189255116606 bayes_pls_golite062009
insulin receptor binding 0.266450215230107 bayes_pls_golite062009
substrate-specific channel activity 0.261869836686301 bayes_pls_golite062009
RNA binding 0.245748631571068 bayes_pls_golite062009
ion channel activity 0.241519346930618 bayes_pls_golite062009
nuclear hormone receptor binding 0.240883589532225 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
insulin receptor activity 0.237134032032089 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 0.149958560815481 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 0.149958560815481 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 0.14842991990838 bayes_pls_golite062009
peptide binding 0.118578378753757 bayes_pls_golite062009
transforming growth factor beta receptor activity, type I 0.0506751594607393 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [118-375] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPETLQIEIN RYVTNKLEMP LKHIRLYTYQ IARGMLYLHG LGVCHRDIKP SNVLVDPETG  60
   61 VLKICDFGSA KKLEHNQPSI SYICSRFYRA PELIIGCTQY TTQIDIWGLG CVMGEMLIGK 120
  121 AIFQGQEPLL QLREIAKLLG PPDKRFIFFS NPAYDGPLFS KPLFSGSSQQ RFEKYFGHSG 180
  181 PDGIDLLMKI LVYEPQQRLS PRRILAHQFF NELRNDDTFL PRGFTEPIKL PNLFDFNDFE 240
  241 LQILGEFADK IKPTKVAE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 811.9897
Match: 1i09A_
Description: Glycogen synthase kinase-3 beta (Gsk3b)
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle