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View Structure Prediction Details

Protein: CBK1
Organism: Saccharomyces cerevisiae
Length: 756 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CBK1.

Description E-value Query
Range
Subject
Range
CBK1_YEAST - Serine/threonine-protein kinase CBK1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CBK...
CBK1 - Serine/threonine protein kinase that regulates cell morphogenesis pathways; involved in cell wall bi...
0.0 [1..756] [1..756]
LATS2 - LATS, large tumor suppressor, homolog 2 (Drosophila)
0.0 [16..747] [254..1045]
gi|4204296, gi|2... - gi|4204296|gb|AAD10677.1| putative protien kinase [Arabidopsis thaliana], pir||A86170 hypothetical p...
0.0 [214..752] [2..506]
gi|7339534 - gi|7339534|emb|CAB82852.1| protein kinase MK6 [Mesembryanthemum crystallinum]
0.0 [243..752] [14..494]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [253..752] [12..491]
gi|125532353 - gi|125532353|gb|EAY78918.1| hypothetical protein OsI_34019 [Oryza sativa Indica Group]
gi|13129502, gi|... - gi|37535354|ref|NP_921979.1| putative protein kinase [Oryza sativa (japonica cultivar-group)], gi|31...
0.0 [264..756] [25..489]

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Predicted Domain #1
Region A:
Residues: [1-323]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYNSSTNHHE GAPTSGHGYY MSQQQDQQHQ QQQQYANEMN PYQQIPRPPA AGFSSNYMKE  60
   61 QGSHQSLQEH LQRETGNLGS GFTDVPALNY PATPPPHNNY AASNQMINTP PPSMGGLYRH 120
  121 NNNSQSMVQN GNGSGNAQLP QLSPGQYSIE SEYNQNLNGS SSSSPFHQPQ TLRSNGSYSS 180
  181 GLRSVKSFQR LQQEQENVQV QQQLSQAQQQ NSRQQQQQLQ YQQQQQQQQQ QQHMQIQQQQ 240
  241 QQQQQQQQSQ SPVQSGFNNG TISNYMYFER RPDLLTKGTQ DKAAAVKLKI ENFYQSSVKY 300
  301 AIERNERRVE LETELTSHNW SEE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [324-503]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKSRQLSSLG KKESQFLRLR RTRLSLEDFH TVKVIGKGAF GEVRLVQKKD TGKIYAMKTL  60
   61 LKSEMYKKDQ LAHVKAERDV LAGSDSPWVV SLYYSFQDAQ YLYLIMEFLP GGDLMTMLIR 120
  121 WQLFTEDVTR FYMAECILAI ETIHKLGFIH RDIKPDNILI DIRGHIKLSD FGLSTGFHKT 180
  181 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 94.0
Match: 1lhxA_
Description: No description for 1lhxA_ was found.

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
calmodulin-dependent protein kinase activity 5.10630503791738 bayes_pls_golite062009
cyclic nucleotide-dependent protein kinase activity 4.97855712164511 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
cAMP-dependent protein kinase activity 4.66277812893755 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
phosphorylase kinase activity 4.23570595363447 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
actin binding 2.91722352767433 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
structural molecule activity 2.60280308499348 bayes_pls_golite062009
transmembrane receptor activity 2.59526003830791 bayes_pls_golite062009
transmembrane receptor protein kinase activity 2.54265774272269 bayes_pls_golite062009
ion transmembrane transporter activity 2.52531786618214 bayes_pls_golite062009
cation transmembrane transporter activity 2.46424348876434 bayes_pls_golite062009
molecular transducer activity 2.40586892801446 bayes_pls_golite062009
signal transducer activity 2.40586892801446 bayes_pls_golite062009
receptor activity 2.39311927684508 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.37122853419919 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 2.16831387024372 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
metal ion transmembrane transporter activity 1.9016235206634 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
molecular adaptor activity 1.81145713371725 bayes_pls_golite062009
actin filament binding 1.75933904320288 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
insulin receptor substrate binding 1.62657794525303 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.6084489855403 bayes_pls_golite062009
SH3/SH2 adaptor activity 1.59474164216385 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
JUN kinase kinase kinase kinase activity 1.55257528159541 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
gamma-tubulin binding 1.28511591054866 bayes_pls_golite062009
kinase binding 1.26086833316556 bayes_pls_golite062009
phosphoinositide 3-kinase binding 1.25285260301349 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
nucleic acid binding 1.16049201286103 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
protein kinase binding 1.06030596516506 bayes_pls_golite062009
cation channel activity 1.04999722123563 bayes_pls_golite062009
telethonin binding 1.04264263421201 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
cyclin-dependent protein kinase activity 0.959360414036299 bayes_pls_golite062009
growth factor binding 0.86076618871384 bayes_pls_golite062009
protein binding, bridging 0.83823250804321 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 0.835012681606991 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 0.835012681606991 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 0.832111648073981 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
structural constituent of muscle 0.767275562047313 bayes_pls_golite062009
substrate-specific transporter activity 0.705905455086486 bayes_pls_golite062009
phosphoinositide 3-kinase regulator activity 0.688047400629641 bayes_pls_golite062009
vinculin binding 0.666656406096231 bayes_pls_golite062009
ligase activity 0.665445021164512 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
acetylcholine receptor binding 0.594548112804154 bayes_pls_golite062009
transcription repressor activity 0.568332175782799 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
MAP kinase kinase activity 0.35402045013148 bayes_pls_golite062009
phosphotyrosine binding 0.311079584914389 bayes_pls_golite062009
passive transmembrane transporter activity 0.287189255116606 bayes_pls_golite062009
channel activity 0.287189255116606 bayes_pls_golite062009
structure-specific DNA binding 0.267404531445803 bayes_pls_golite062009
insulin receptor binding 0.266450215230107 bayes_pls_golite062009
substrate-specific channel activity 0.261869836686301 bayes_pls_golite062009
myosin binding 0.259936573810332 bayes_pls_golite062009
RNA binding 0.245748631571068 bayes_pls_golite062009
ion channel activity 0.241519346930618 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
insulin receptor activity 0.237134032032089 bayes_pls_golite062009
SH2 domain binding 0.226760162354251 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 0.20643152368029 bayes_pls_golite062009
transforming growth factor beta receptor activity 0.20643152368029 bayes_pls_golite062009
alpha-actinin binding 0.181804774839734 bayes_pls_golite062009
protein kinase C activity 0.0795689006739899 bayes_pls_golite062009
transforming growth factor beta receptor activity, type I 0.0506751594607393 bayes_pls_golite062009
actin-dependent ATPase activity 0.0339299940546054 bayes_pls_golite062009
MAP kinase kinase kinase kinase activity 0.01826424351081 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [504-636]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HDSNYYKKLL QQDEATNGIS KPGTYNANTT DTANKRQTMV VDSISLTMSN RQQIQTWRKS  60
   61 RRLMAYSTVG TPDYIAPEIF LYQGYGQECD WWSLGAIMYE CLIGWPPFCS ETPQETYRKI 120
  121 MNFEQTLQFP DDI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [637-756]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HISYEAEDLI RRLLTHADQR LGRHGGADEI KSHPFFRGVD WNTIRQVEAP YIPKLSSITD  60
   61 TRFFPTDELE NVPDSPAMAQ AAKQREQMTK QGGSAPVKED LPFIGYTYSR FDYLTRKNAL 120
  121 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 440.228787
Match: 1ctpE_
Description: cAMP-dependent PK, catalytic subunit
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle