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Protein: YKL161C
Organism: Saccharomyces cerevisiae
Length: 433 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YKL161C.

Description E-value Query
Range		 Subject
Range
gi|12407837 - gi|12407837|gb|AAG53655.1|AF301166_1 MAP kinase-II [Blumeria graminis]
 0.0 [1..403] [1..398]
KDX1_YEAST - Serine/threonine-protein kinase KDX1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=KDX...
YKL161C - Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; associates ...
 0.0 [1..433] [1..433]
gi|38105874, gi|... - gi|39940594|ref|XP_359834.1| hypothetical protein MGG_04943 [Magnaporthe grisea 70-15], gb|EAA52251....
gi|2465400 - gi|2465400|gb|AAC63682.1| MAP kinase Mps1 [Magnaporthe grisea]
 0.0 [1..395] [1..394]
gi|7385125 - gi|7385125|gb|AAF61706.1|AF226711_1 MAP kinase [Kluyveromyces lactis]
 0.0 [6..425] [8..439]
gi|4580577 - gi|4580577|gb|AAD24428.1|U59214_1 MAP protein kinase MPKA [Emericella nidulans]
 0.0 [6..366] [8..364]
gi|17978662 - gi|17978662|gb|AAL50116.1| mitogen-activated protein kinase [Colletotrichum lagenarium]
 0.0 [1..400] [1..396]
MPK4_ARATH - Mitogen-activated protein kinase 4 OS=Arabidopsis thaliana GN=MPK4 PE=1 SV=2
 0.0 [2..366] [21..372]
MK07_MOUSE - Mitogen-activated protein kinase 7 OS=Mus musculus GN=Mapk7 PE=1 SV=1
gi|117616350 - gi|117616350|gb|ABK42193.1| Erk5 [synthetic construct]
 0.0 [13..427] [45..474]

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Predicted Domain #1
Region A:
Residues: [1-74] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATDTERCIF RAFGQDFILN KHFHLTGKIG RGSHSLICSS TYTESNEETH VAIRKIPNAF  60
   61 GNKLSCKRTL RELK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [88-110] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LFDTDIVFYP NGALNGVYLY EEL

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [340-433] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HIESMAELGN EVIKEVFDFR KVVRKHPISG DSPSSSLSLE DAIPQEVVQV HPSRKVLPSY  60
   61 SPEFSYVSQL PSLTTTQPYQ NLMGISSNSF QGVN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 858.0103
Match: 1gol__
Description: MAP kinase Erk2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
acetylcholine receptor activator activity 5.9159846946654 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 5.68265749805481 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 5.49988294224815 bayes_pls_golite062009
protein kinase activity 5.4586557943719 bayes_pls_golite062009
kinase activity 5.3287080791198 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.96052051118534 bayes_pls_golite062009
transcription elongation regulator activity 4.93646793786886 bayes_pls_golite062009
cyclin-dependent protein kinase activity 4.62392503670521 bayes_pls_golite062009
protein serine/threonine kinase activity 4.46381887831481 bayes_pls_golite062009
transferase activity 3.97138602499442 bayes_pls_golite062009
structural molecule activity 3.82327979736517 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 3.41480681854114 bayes_pls_golite062009
transmembrane receptor protein kinase activity 3.40140621607334 bayes_pls_golite062009
MAP kinase 2 activity 3.27009208121248 bayes_pls_golite062009
protein tyrosine kinase activity 2.8153155526437 bayes_pls_golite062009
phosphoinositide 3-kinase binding 2.79505438761262 bayes_pls_golite062009
binding 2.74863538127007 bayes_pls_golite062009
transmembrane receptor activity 2.59526003830791 bayes_pls_golite062009
ion transmembrane transporter activity 2.52531786618214 bayes_pls_golite062009
cation transmembrane transporter activity 2.46424348876434 bayes_pls_golite062009
signal transducer activity 2.40586892801446 bayes_pls_golite062009
molecular transducer activity 2.40586892801446 bayes_pls_golite062009
receptor activity 2.39311927684508 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.37122853419919 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity 2.30873410607588 bayes_pls_golite062009
transforming growth factor beta receptor activity 2.30873410607588 bayes_pls_golite062009
histone kinase activity (H3-S10 specific) 2.30449166929476 bayes_pls_golite062009
protein binding 2.276111749106 bayes_pls_golite062009
tubulin binding 2.18641675163967 bayes_pls_golite062009
cytoskeletal protein binding 2.12615078788254 bayes_pls_golite062009
receptor signaling protein activity 2.10379226653669 bayes_pls_golite062009
ATP binding 1.97600611746091 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.94085498993561 bayes_pls_golite062009
adenyl ribonucleotide binding 1.93596671856664 bayes_pls_golite062009
adenyl nucleotide binding 1.90928021591891 bayes_pls_golite062009
metal ion transmembrane transporter activity 1.9016235206634 bayes_pls_golite062009
microtubule binding 1.88110801192607 bayes_pls_golite062009
actin binding 1.87817875565699 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.81249386965144 bayes_pls_golite062009
telethonin binding 1.75733591474207 bayes_pls_golite062009
transforming growth factor beta receptor activity, type I 1.74645334586495 bayes_pls_golite062009
small conjugating protein ligase activity 1.74206248731815 bayes_pls_golite062009
activin binding 1.69795678545106 bayes_pls_golite062009
fibroblast growth factor 1 binding 1.66976264488423 bayes_pls_golite062009
purine ribonucleotide binding 1.65732943334212 bayes_pls_golite062009
ribonucleotide binding 1.65726906484847 bayes_pls_golite062009
activin receptor activity 1.64506335968643 bayes_pls_golite062009
purine nucleotide binding 1.63763394711025 bayes_pls_golite062009
nucleotide binding 1.63195828048121 bayes_pls_golite062009
insulin receptor substrate binding 1.62657794525303 bayes_pls_golite062009
JUN kinase kinase kinase activity 1.60259443694567 bayes_pls_golite062009
transcription regulator activity 1.56748951434625 bayes_pls_golite062009
growth factor binding 1.53863828216563 bayes_pls_golite062009
nucleic acid binding 1.46547714006072 bayes_pls_golite062009
MAP kinase kinase activity 1.42275431028856 bayes_pls_golite062009
DNA binding 1.35333135345112 bayes_pls_golite062009
ErbB-3 class receptor binding 1.34841233233438 bayes_pls_golite062009
ErbB-2 class receptor binding 1.33825339298024 bayes_pls_golite062009
kinase binding 1.26086833316556 bayes_pls_golite062009
acid-amino acid ligase activity 1.2266791546014 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
transcription repressor activity 1.14496167267281 bayes_pls_golite062009
transporter activity 1.11833481501707 bayes_pls_golite062009
non-membrane spanning protein tyrosine kinase activity 1.11664317075762 bayes_pls_golite062009
transcription factor activity 1.10928254946881 bayes_pls_golite062009
protein kinase binding 1.06030596516506 bayes_pls_golite062009
cation channel activity 1.04999722123563 bayes_pls_golite062009
type II transforming growth factor beta receptor binding 1.03605423743048 bayes_pls_golite062009
SMAD binding 1.02108562119195 bayes_pls_golite062009
transcription activator activity 0.997272622653026 bayes_pls_golite062009
PTB domain binding 0.9900774724568 bayes_pls_golite062009
transmembrane transporter activity 0.97575992765505 bayes_pls_golite062009
alpha-actinin binding 0.877087652539674 bayes_pls_golite062009
insulin-like growth factor receptor binding 0.872782211382796 bayes_pls_golite062009
fibroblast growth factor binding 0.870666814073948 bayes_pls_golite062009
activin receptor activity, type I 0.82317428935631 bayes_pls_golite062009
MAP kinase activity 0.81943579965027 bayes_pls_golite062009
actin filament binding 0.794152600084 bayes_pls_golite062009
fibroblast growth factor receptor activity 0.75189004129952 bayes_pls_golite062009
receptor serine/threonine kinase binding 0.728917900114111 bayes_pls_golite062009
substrate-specific transporter activity 0.705905455086486 bayes_pls_golite062009
transforming growth factor beta receptor binding 0.705634826374884 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 0.705634826374884 bayes_pls_golite062009
hormone receptor binding 0.705067960165986 bayes_pls_golite062009
beta-catenin binding 0.693246095477001 bayes_pls_golite062009
structural constituent of cytoskeleton 0.612883428421652 bayes_pls_golite062009
JUN kinase kinase kinase kinase activity 0.546647574638943 bayes_pls_golite062009
cyclin-dependent protein kinase activating kinase activity 0.529121666062889 bayes_pls_golite062009
steroid hormone receptor binding 0.505233004492768 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.48345772948903 bayes_pls_golite062009
enzyme binding 0.46284745266176 bayes_pls_golite062009
transforming growth factor beta binding 0.435457844706269 bayes_pls_golite062009
protein kinase C activity 0.41587987561486 bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity 0.406297251827056 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.401250804041384 bayes_pls_golite062009
structural constituent of muscle 0.399773397398032 bayes_pls_golite062009
magnesium ion binding 0.393328812780268 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.37115026509016 bayes_pls_golite062009
JUN kinase kinase activity 0.332372116912461 bayes_pls_golite062009
structure-specific DNA binding 0.318153468064373 bayes_pls_golite062009
channel activity 0.287189255116606 bayes_pls_golite062009
passive transmembrane transporter activity 0.287189255116606 bayes_pls_golite062009
insulin receptor binding 0.266450215230107 bayes_pls_golite062009
substrate-specific channel activity 0.261869836686301 bayes_pls_golite062009
RNA binding 0.245748631571068 bayes_pls_golite062009
ion channel activity 0.241519346930618 bayes_pls_golite062009
nuclear hormone receptor binding 0.240883589532225 bayes_pls_golite062009
protein complex binding 0.239339759110451 bayes_pls_golite062009
insulin receptor activity 0.237134032032089 bayes_pls_golite062009
SH2 domain binding 0.226760162354251 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 0.149958560815481 bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds 0.149958560815481 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 0.14842991990838 bayes_pls_golite062009
peptide binding 0.118578378753757 bayes_pls_golite062009
brain-derived neurotrophic factor binding 0.0794053647730006 bayes_pls_golite062009
nitric-oxide synthase regulator activity 0.00407218246327123 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.0040394359628233 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [75-87] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLRHLRGHPN IVW

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [111-339] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MECDLSQIIR SEQRLEDAHF QSFIYQILCA LKYIHSANVL HCDLKPKNLL VNSDCQLKIC  60
   61 NFGLSCSYSE NHKVNDGFIK GYITSIWYKA PEILLNYQEC TKAVDIWSTG CILAELLGRK 120
  121 PMFEGKDYVD HLNHILQILG TPPEETLQEI ASQKVYNYIF QFGNIPGRSF ESILPGANPE 180
  181 ALELLKKMLE FDPKKRITVE DALEHPYLSM WHDIDEEFSC QKTFRFEFE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 858.0103
Match: 1gol__
Description: MAP kinase Erk2
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle