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View Structure Prediction Details

Protein: PDR11
Organism: Saccharomyces cerevisiae
Length: 1411 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PDR11.

Description E-value Query
Range		 Subject
Range
gi|18152891 - gi|18152891|gb|AAK62810.2|AF227914_1 ATP-binding cassette transporter ABC1 [Venturia inaequalis]
 0.0 [10..1409] [162..1537]
CDR4_CANAX - ABC transporter CDR4 OS=Candida albicans GN=CDR4 PE=3 SV=1
 0.0 [2..1381] [114..1480]
PDR11 - ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; ...
gi|151943145 - gi|151943145|gb|EDN61480.1| multidrug transporter [Saccharomyces cerevisiae YJM789]
gi|207344265 - gi|207344265|gb|EDZ71467.1| YIL013Cp-like protein [Saccharomyces cerevisiae AWRI1631]
PDR11_YEAST - ATP-dependent permease PDR11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PDR11 PE=1 ...
 0.0 [1..1411] [1..1411]
gi|66826585, gi|... - gi|66826585|ref|XP_646647.1| ABC transporter G family protein [Dictyostelium discoideum AX4], gi|604...
ABCGJ_DICDI - ABC transporter G family member 19 OS=Dictyostelium discoideum GN=abcG19 PE=3 SV=1
 0.0 [9..1381] [106..1448]
gi|6175524 - gi|6175524|gb|AAF05069.1|AF109723_1 ATP-binding cassette transporter [Candida glabrata]
 0.0 [2..1389] [103..1499]
gi|14278974 - gi|14278974|dbj|BAB59028.1| ABC transporter PMR5 [Penicillium digitatum]
 0.0 [9..1382] [69..1411]

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Predicted Domain #1
Region A:
Residues: [1-294] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLSKYFNPI PDASVTFDGA TVQLEESLGA VQNDEESASE FKNVGHLEIS DITFRANEGE  60
   61 VVLVLGNPTS ALFKGLFHGH KHLKYSPEGS IRFKDNEYKQ FASKCPHQII YNNEQDIHFP 120
  121 YLTVEQTIDF ALSCKFHIPK QERIEMRDEL LKEFGLSHVK KTYVGNDYVR GVSGGERKRI 180
  181 SIIETFIANG SVYLWDNSTK GLDSATALEF LSITQKMAKA TRSVNFVKIS QASDKIVSKF 240
  241 DKILMLGDSF QVFYGTMEEC LTHFHDTLQI KKNPNDCIIE YLTSILNFKF KETS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 133.68867
Match: 1l2tA_
Description: MJ0796
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
P-P-bond-hydrolysis-driven transmembrane transporter activity 6.58863529263644 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 6.58067278719409 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 6.57974651657836 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 6.57922174989907 bayes_pls_golite062009
primary active transmembrane transporter activity 6.57807080367604 bayes_pls_golite062009
nucleoside-triphosphatase activity 6.48406410175216 bayes_pls_golite062009
active transmembrane transporter activity 6.48154954364331 bayes_pls_golite062009
pyrophosphatase activity 6.40467109535527 bayes_pls_golite062009
ATPase activity, coupled 6.40151534181487 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 6.38373914253885 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 6.38247436082206 bayes_pls_golite062009
ATPase activity 6.30019941712404 bayes_pls_golite062009
hydrolase activity 4.60957912556603 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 3.57926427233638 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.4837867129694 bayes_pls_golite062009
purine ribonucleotide binding 3.40690615950081 bayes_pls_golite062009
ribonucleotide binding 3.40594996232845 bayes_pls_golite062009
purine nucleotide binding 3.3669118613715 bayes_pls_golite062009
ion transmembrane transporter activity 3.35436118751376 bayes_pls_golite062009
nucleotide binding 3.33248266870364 bayes_pls_golite062009
ATP binding 3.17398570826788 bayes_pls_golite062009
adenyl ribonucleotide binding 3.12628113185041 bayes_pls_golite062009
transporter activity 3.10463051760206 bayes_pls_golite062009
cation transmembrane transporter activity 3.08390071341252 bayes_pls_golite062009
adenyl nucleotide binding 3.0710107594224 bayes_pls_golite062009
iron ion transmembrane transporter activity 3.05511942104215 bayes_pls_golite062009
drug transmembrane transporter activity 2.97119034312001 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity 2.88795687640992 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.88476360771975 bayes_pls_golite062009
amine-transporting ATPase activity 2.69529191205818 bayes_pls_golite062009
organic acid transmembrane transporter activity 2.67957846350199 bayes_pls_golite062009
carboxylic acid transmembrane transporter activity 2.67815672695824 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 2.61311581579476 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.40292717311506 bayes_pls_golite062009
amine transmembrane transporter activity 2.29486577878686 bayes_pls_golite062009
2.20174656498665 bayes_pls_golite062009
syntaxin-13 binding 2.15656963765495 bayes_pls_golite062009
apolipoprotein receptor activity 2.15656963765495 bayes_pls_golite062009
apolipoprotein A-I binding 2.15656963765495 bayes_pls_golite062009
apolipoprotein A-I receptor activity 2.15656963765495 bayes_pls_golite062009
anion transmembrane-transporting ATPase activity 2.12727614888121 bayes_pls_golite062009
binding 2.0681607836408 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 1.88153949603611 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 1.82177108193332 bayes_pls_golite062009
fluconazole transporter activity 1.75428613304237 bayes_pls_golite062009
azole transporter activity 1.75428613304237 bayes_pls_golite062009
cholesterol transporter activity 1.61368800389403 bayes_pls_golite062009
amino acid transmembrane transporter activity 1.59627719545436 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.58971273330352 bayes_pls_golite062009
sterol transporter activity 1.49412408393009 bayes_pls_golite062009
peptide-transporting ATPase activity 1.37783759788533 bayes_pls_golite062009
cation channel activity 1.33585529285301 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.23799860254751 bayes_pls_golite062009
peptide transporter activity 1.19353064661766 bayes_pls_golite062009
potassium channel activity 1.17288958041707 bayes_pls_golite062009
lipid transporter activity 1.10957173853622 bayes_pls_golite062009
voltage-gated cation channel activity 1.00384984515681 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
nucleic acid binding 0.896078342024449 bayes_pls_golite062009
voltage-gated ion channel activity 0.889208591820696 bayes_pls_golite062009
voltage-gated channel activity 0.871525745291603 bayes_pls_golite062009
0.869999622006359 bayes_pls_golite062009
ion channel activity 0.848261056209476 bayes_pls_golite062009
channel activity 0.806331380134838 bayes_pls_golite062009
passive transmembrane transporter activity 0.806331380134838 bayes_pls_golite062009
substrate-specific channel activity 0.799997700906738 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.767424210804186 bayes_pls_golite062009
phospholipid transporter activity 0.755445322666929 bayes_pls_golite062009
gated channel activity 0.650050847753837 bayes_pls_golite062009
DNA-dependent ATPase activity 0.62832939629645 bayes_pls_golite062009
anion transmembrane transporter activity 0.43332053110728 bayes_pls_golite062009
protein binding 0.378225828131122 bayes_pls_golite062009
DNA binding 0.361518668029935 bayes_pls_golite062009
GTPase activity 0.20164416416912 bayes_pls_golite062009
amino acid-transporting ATPase activity 0.147644650870465 bayes_pls_golite062009
motor activity 0.14734538548583 bayes_pls_golite062009
transcription regulator activity 0.133605084599819 bayes_pls_golite062009
protein transporter activity 0.104820191623932 bayes_pls_golite062009
cation-transporting ATPase activity 0.0536898657672154 bayes_pls_golite062009
structure-specific DNA binding 0.050232896280066 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [295-360] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSIVGLDTPS VVSEENQALN INNETDLHTL WIQSPYYKHW KAITSKTVQE CTRKDVNPDD  60
   61 ISPIFS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [361-584] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPLKTQLKTC TVRAFERIIG DRNYLISQFV SVVVQSLVIG SLFYNIPLTT IGSFSRGSLT  60
   61 FFSILFFTFL SLADMPASFQ RQPVVRKHVQ LHFYYNWVET LATNFFDCCS KFILVVIFTI 120
  121 ILYFLAHLQY NAARFFIFLL FLSVYNFCMV SLFALTALIA PTLSMANLLA GILLLAIAMY 180
  181 ASYVIYMKDM HPWFIWIAYL NPAMFAMEAI LSNELFNLKL DCHE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [585-728] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SIIPRGEYYD NISFSHKACA WQGATLGNDY VRGRDYLKSG LKYTYHHVWR NFGIIIGFLC  60
   61 FFLFCSLLAA EYITPLFTRE NLLRWNNYLK RYCPFLNSQK KNNKSAITNN DGVCTPKTPI 120
  121 ANFSTSSSSV PSVSHQYDTD YNIK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [729-1055] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HPDETVNNHT KESVAMETQK HVISWKNINY TIGDKKLIND ASGYISSGLT ALMGESGAGK  60
   61 TTLLNVLSQR TESGVVTGEL LIDGQPLTNI DAFRRSIGFV QQQDVHLELL TVRESLEISC 120
  121 VLRGDGDRDY LGVVSNLLRL PSEKLVADLS PTQRKLLSIG VELVTKPSLL LFLDEPTSGL 180
  181 DAEAALTIVQ FLKKLSMQGQ AILCTIHQPS KSVISYFDNI YLLKRGGECV YFGSLPNACD 240
  241 YFVAHDRRLT FDREMDNPAD FVIDVVGSGS TNIPMDDAEK PTSSKIDEPV SYHKQSDSIN 300
  301 WAELWQSSPE KVRVADDLLL LEEEARK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 140.927757
Match: 1g291_
Description: Maltose transport protein MalK, C-terminal domain; Maltose transport protein MalK, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
P-P-bond-hydrolysis-driven transmembrane transporter activity 6.58863529263644 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 6.58067278719409 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances 6.57974651657836 bayes_pls_golite062009
ATPase activity, coupled to movement of substances 6.57922174989907 bayes_pls_golite062009
primary active transmembrane transporter activity 6.57807080367604 bayes_pls_golite062009
nucleoside-triphosphatase activity 6.48406410175216 bayes_pls_golite062009
active transmembrane transporter activity 6.48154954364331 bayes_pls_golite062009
pyrophosphatase activity 6.40467109535527 bayes_pls_golite062009
ATPase activity, coupled 6.40151534181487 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 6.38373914253885 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 6.38247436082206 bayes_pls_golite062009
ATPase activity 6.30019941712404 bayes_pls_golite062009
hydrolase activity 4.60957912556603 bayes_pls_golite062009
hydrogen ion transporting ATP synthase activity, rotational mechanism 3.57926427233638 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.4837867129694 bayes_pls_golite062009
purine ribonucleotide binding 3.40690615950081 bayes_pls_golite062009
ribonucleotide binding 3.40594996232845 bayes_pls_golite062009
purine nucleotide binding 3.3669118613715 bayes_pls_golite062009
ion transmembrane transporter activity 3.35436118751376 bayes_pls_golite062009
nucleotide binding 3.33248266870364 bayes_pls_golite062009
ATP binding 3.17398570826788 bayes_pls_golite062009
adenyl ribonucleotide binding 3.12628113185041 bayes_pls_golite062009
cation transmembrane transporter activity 3.08390071341252 bayes_pls_golite062009
adenyl nucleotide binding 3.0710107594224 bayes_pls_golite062009
iron ion transmembrane transporter activity 3.05511942104215 bayes_pls_golite062009
drug transmembrane transporter activity 2.97119034312001 bayes_pls_golite062009
transmembrane transporter activity 2.95886887664984 bayes_pls_golite062009
branched-chain aliphatic amino acid transmembrane transporter activity 2.88795687640992 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.88476360771975 bayes_pls_golite062009
amine-transporting ATPase activity 2.69529191205818 bayes_pls_golite062009
organic acid transmembrane transporter activity 2.67957846350199 bayes_pls_golite062009
carboxylic acid transmembrane transporter activity 2.67815672695824 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 2.61311581579476 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.40292717311506 bayes_pls_golite062009
amine transmembrane transporter activity 2.29486577878686 bayes_pls_golite062009
2.20174656498665 bayes_pls_golite062009
apolipoprotein A-I receptor activity 2.15656963765495 bayes_pls_golite062009
apolipoprotein receptor activity 2.15656963765495 bayes_pls_golite062009
syntaxin-13 binding 2.15656963765495 bayes_pls_golite062009
apolipoprotein A-I binding 2.15656963765495 bayes_pls_golite062009
anion transmembrane-transporting ATPase activity 2.12727614888121 bayes_pls_golite062009
transporter activity 1.9862037182943 bayes_pls_golite062009
substrate-specific transporter activity 1.91091452720653 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 1.88153949603611 bayes_pls_golite062009
transition metal ion transmembrane transporter activity 1.82177108193332 bayes_pls_golite062009
fluconazole transporter activity 1.75428613304237 bayes_pls_golite062009
azole transporter activity 1.75428613304237 bayes_pls_golite062009
cholesterol transporter activity 1.61368800389403 bayes_pls_golite062009
amino acid transmembrane transporter activity 1.59627719545436 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 1.58971273330352 bayes_pls_golite062009
binding 1.49433277484566 bayes_pls_golite062009
sterol transporter activity 1.49412408393009 bayes_pls_golite062009
peptide-transporting ATPase activity 1.37783759788533 bayes_pls_golite062009
cation channel activity 1.33585529285301 bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of ions 1.23799860254751 bayes_pls_golite062009
peptide transporter activity 1.19353064661766 bayes_pls_golite062009
potassium channel activity 1.17288958041707 bayes_pls_golite062009
lipid transporter activity 1.10957173853622 bayes_pls_golite062009
nucleic acid binding 1.02585080387771 bayes_pls_golite062009
voltage-gated cation channel activity 1.00384984515681 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
transcription regulator activity 0.960964717764622 bayes_pls_golite062009
voltage-gated ion channel activity 0.889208591820696 bayes_pls_golite062009
voltage-gated channel activity 0.871525745291603 bayes_pls_golite062009
0.869999622006359 bayes_pls_golite062009
ion channel activity 0.848261056209476 bayes_pls_golite062009
DNA binding 0.827956993331319 bayes_pls_golite062009
passive transmembrane transporter activity 0.806331380134838 bayes_pls_golite062009
channel activity 0.806331380134838 bayes_pls_golite062009
substrate-specific channel activity 0.799997700906738 bayes_pls_golite062009
di-, tri-valent inorganic cation transmembrane transporter activity 0.767424210804186 bayes_pls_golite062009
phospholipid transporter activity 0.755445322666929 bayes_pls_golite062009
gated channel activity 0.650050847753837 bayes_pls_golite062009
DNA-dependent ATPase activity 0.62832939629645 bayes_pls_golite062009
transition metal ion binding 0.565091767161677 bayes_pls_golite062009
transcription factor activity 0.529204993559159 bayes_pls_golite062009
anion transmembrane transporter activity 0.43332053110728 bayes_pls_golite062009
protein binding 0.378225828131122 bayes_pls_golite062009
GTPase activity 0.20164416416912 bayes_pls_golite062009
amino acid-transporting ATPase activity 0.147644650870465 bayes_pls_golite062009
motor activity 0.14734538548583 bayes_pls_golite062009
protein transporter activity 0.104820191623932 bayes_pls_golite062009
cation-transporting ATPase activity 0.0536898657672154 bayes_pls_golite062009
structure-specific DNA binding 0.050232896280066 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [1056-1316] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGVDFTTSVW SPPSYMEQIK LITKRQYICT KRDMTYVFAK YALNAGAGLF IGFSFWRTKH  60
   61 NINGLQDAIF LCFMMLCVSS PLINQVQDKA LQSKEVYIAR EARSNTYHWT VLLIAQTIVE 120
  121 LPLAISSSTL FFLCCYFCCG FETSARVAGV FYLNYILFSM YYLSFGLWLL YSAPDLQTAA 180
  181 VFVAFLYSFT ASFCGVMQPY SLFPRFWTFM YRVSPYTYFI ETFVSLLLHD REVNCSTSEM 240
  241 VPSQPVMGQT CGQFMKPFID E

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1317-1411] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FGGKLHINNT YTVCAYCMYT VGDDFLAQEN MSYHHRWRNF GFEWVFVCFN IAAMFVGFYL  60
   61 TYIKKIWPSV IDGIKKCIPS MRRSKTSHNP NEQSV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score		 SCOP
Match		 SCOP Description
View Download 0.863 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle