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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Kap104. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 13 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ADH4
  • mitochondrion
  • fermentation
  • NADH oxidation
  • alcohol dehydrogenase activity, zinc-dependent
  • ARC1
  • cytoplasm
  • methionyl glutamyl tRNA synthetase complex
  • tRNA aminoacylation for protein translation
  • tRNA export from nucleus
  • tRNA binding
  • ENP1
  • nucleus
  • nuclear outer membrane
  • nucleolus
  • preribosome, small subunit precursor
  • ribosome biogenesis
  • rRNA processing
  • snoRNA binding
  • HEM15
  • mitochondrion
  • mitochondrial inner membrane
  • heme biosynthetic process
  • ferrochelatase activity
  • HRP1
  • nucleus
  • cytoplasm
  • mRNA cleavage factor complex
  • mRNA polyadenylation
  • mRNA cleavage
  • RNA binding
  • HTA2
  • nuclear nucleosome
  • DNA repair
  • chromatin assembly or disassembly
  • DNA binding
  • KAP104
  • cytosol
  • mRNA-binding (hnRNP) protein import into nucleus
  • protein import into nucleus
  • cell cycle
  • nuclear localization sequence binding
  • KTR3
  • membrane fraction
  • protein amino acid O-linked glycosylation
  • cellular cell wall organization
  • protein amino acid N-linked glycosylation
  • mannosyltransferase activity
  • NAB2
  • nucleus
  • cytoplasm
  • mRNA polyadenylation
  • poly(A)+ mRNA export from nucleus
  • poly(A) RNA binding
  • NDE1
  • mitochondrion
  • NADH oxidation
  • glucose catabolic process to ethanol
  • chronological cell aging
  • NADH dehydrogenase activity
  • PAA1
  • cytoplasm
  • chromatin organization
  • diamine N-acetyltransferase activity
  • aralkylamine N-acetyltransferase activity
  • RPT4
  • nucleus
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • YNL035C
  • nucleus
  • biological_process
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    methionyl glutamyl tRNA synthetase complex 8.2408E-3 13 4 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    NADH oxidation 2.571E-4 13 12 2 6292
    NADH metabolic process 4.0759E-4 13 15 2 6292
    mRNA polyadenylation 6.607E-4 13 19 2 6292
    fermentation 7.3325E-4 13 20 2 6292
    NAD metabolic process 1.151E-3 13 25 2 6292
    RNA polyadenylation 1.2455E-3 13 26 2 6292
    mRNA 3'-end processing 1.7717E-3 13 31 2 6292
    nuclear transport 2.1181E-3 13 130 3 6292
    nucleocytoplasmic transport 2.1181E-3 13 130 3 6292
    RNA 3'-end processing 3.2387E-3 13 42 2 6292
    nicotinamide nucleotide metabolic process 3.3927E-3 13 43 2 6292
    cofactor metabolic process 3.4335E-3 13 154 3 6292
    pyridine nucleotide metabolic process 3.8751E-3 13 46 2 6292
    oxidoreduction coenzyme metabolic process 6.3097E-3 13 59 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    diamine N-acetyltransferase activity 2.0661E-3 13 1 1 6292
    aralkylamine N-acetyltransferase activity 2.0661E-3 13 1 1 6292
    alcohol dehydrogenase activity, zinc-dependent 4.1283E-3 13 2 1 6292
    ferrochelatase activity 4.1283E-3 13 2 1 6292
    RNA binding 5.3427E-3 13 367 4 6292
    nuclear localization sequence binding 6.1865E-3 13 3 1 6292
    NADH dehydrogenase activity 6.1865E-3 13 3 1 6292
    nucleic acid binding 8.1613E-3 13 666 5 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle