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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Xrs2. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 6 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
AHP1
  • cytoplasm
  • response to oxidative stress
  • response to metal ion
  • thioredoxin peroxidase activity
  • CDC16
  • anaphase-promoting complex
  • mitotic spindle elongation
  • cyclin catabolic process
  • mitotic sister chromatid segregation
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • protein ubiquitination
  • ubiquitin-protein ligase activity
  • protein binding
  • ERG20
  • cytosol
  • ergosterol biosynthetic process
  • isoprenoid biosynthetic process
  • farnesyl diphosphate biosynthetic process
  • geranyltranstransferase activity
  • dimethylallyltranstransferase activity
  • MRE11
  • nucleus
  • mitochondrion
  • Mre11 complex
  • DNA repair
  • meiotic DNA double-strand break processing
  • double-strand break repair via break-induced replication
  • telomere maintenance
  • double-strand break repair via nonhomologous end joining
  • meiotic DNA double-strand break formation
  • adenylate kinase activity
  • 3'-5' exonuclease activity
  • protein binding
  • telomeric DNA binding
  • endonuclease activity
  • endodeoxyribonuclease activity
  • RAD50
  • nucleus
  • mitochondrion
  • Mre11 complex
  • meiotic DNA double-strand break processing
  • double-strand break repair via break-induced replication
  • telomere maintenance
  • telomere maintenance via recombination
  • double-strand break repair via nonhomologous end joining
  • meiosis
  • meiotic DNA double-strand break formation
  • ATPase activity
  • adenylate kinase activity
  • protein binding
  • telomeric DNA binding
  • double-stranded DNA binding
  • XRS2
  • nucleus
  • Mre11 complex
  • double-strand break repair via break-induced replication
  • telomere maintenance
  • double-strand break repair via nonhomologous end joining
  • sporulation resulting in formation of a cellular spore
  • meiotic DNA double-strand break formation
  • DNA binding
  • protein binding
  • telomeric DNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    Mre11 complex 4.8197E-10 6 3 3 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    double-strand break repair via break-induced replication 4.0399E-8 6 9 3 6292
    meiotic DNA double-strand break formation 7.9298E-8 6 11 3 6292
    double-strand break repair via homologous recombination 7.372E-7 6 22 3 6292
    double-strand break repair via nonhomologous end joining 1.0998E-6 6 25 3 6292
    recombinational repair 1.2428E-6 6 26 3 6292
    meiotic DNA double-strand break processing 2.2727E-6 6 3 2 6292
    non-recombinational repair 2.8523E-6 6 34 3 6292
    nucleic acid phosphodiester bond hydrolysis 7.2044E-6 6 46 3 6292
    DNA catabolic process, exonucleolytic 7.5694E-6 6 5 2 6292
    DNA double-strand break processing 7.5694E-6 6 5 2 6292
    double-strand break repair 1.3832E-5 6 57 3 6292
    meiosis I 3.7087E-5 6 79 3 6292
    M phase 6.5045E-5 6 294 4 6292
    DNA catabolic process 7.9142E-5 6 15 2 6292
    DNA recombination 1.1136E-4 6 114 3 6292
    cell cycle phase 1.7103E-4 6 376 4 6292
    meiosis 3.051E-4 6 160 3 6292
    M phase of meiotic cell cycle 3.051E-4 6 160 3 6292
    meiotic cell cycle 3.2824E-4 6 164 3 6292
    cell cycle process 4.8022E-4 6 490 4 6292
    response to stress 5.0738E-4 6 497 4 6292
    DNA repair 5.2276E-4 6 192 3 6292
    cell cycle 6.2738E-4 6 525 4 6292
    chromosome organization 7.7766E-4 6 555 4 6292
    response to DNA damage stimulus 9.5812E-4 6 236 3 6292
    cellular macromolecule catabolic process 1.344E-3 6 265 3 6292
    anatomical structure homeostasis 1.6779E-3 6 286 3 6292
    telomere organization 1.6779E-3 6 286 3 6292
    telomere maintenance 1.6779E-3 6 286 3 6292
    cellular response to stress 1.747E-3 6 290 3 6292
    macromolecule catabolic process 1.8178E-3 6 294 3 6292
    farnesyl diphosphate biosynthetic process 1.9064E-3 6 2 1 6292
    farnesyl diphosphate metabolic process 1.9064E-3 6 2 1 6292
    response to stimulus 2.6699E-3 6 766 4 6292
    prenol metabolic process 2.8585E-3 6 3 1 6292
    prenol biosynthetic process 2.8585E-3 6 3 1 6292
    polyprenol metabolic process 2.8585E-3 6 3 1 6292
    polyprenol biosynthetic process 2.8585E-3 6 3 1 6292
    cellular response to stimulus 3.7823E-3 6 379 3 6292
    homeostatic process 4.6706E-3 6 408 3 6292
    cellular catabolic process 4.9029E-3 6 415 3 6292
    isoprenoid metabolic process 5.7102E-3 6 6 1 6292
    isoprenoid biosynthetic process 5.7102E-3 6 6 1 6292
    catabolic process 8.1296E-3 6 496 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    telomeric DNA binding 1.0569E-7 6 12 3 6292
    adenylate kinase activity 4.5436E-6 6 4 2 6292
    sequence-specific DNA binding 9.2887E-6 6 50 3 6292
    nucleotide kinase activity 1.1349E-5 6 6 2 6292
    phosphotransferase activity, phosphate group as acceptor 4.1526E-5 6 11 2 6292
    nucleobase, nucleoside, nucleotide kinase activity 4.981E-5 6 12 2 6292
    dimethylallyltranstransferase activity 9.5359E-4 6 1 1 6292
    geranyltranstransferase activity 9.5359E-4 6 1 1 6292
    protein binding 1.1331E-3 6 612 4 6292
    DNA binding 1.2152E-3 6 256 3 6292
    peroxiredoxin activity 8.5551E-3 6 9 1 6292
    thioredoxin peroxidase activity 8.5551E-3 6 9 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle