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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Rad10. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 10 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ARC1
  • cytoplasm
  • methionyl glutamyl tRNA synthetase complex
  • tRNA aminoacylation for protein translation
  • tRNA export from nucleus
  • tRNA binding
  • CPR1
  • nucleus
  • mitochondrion
  • histone deacetylase complex
  • ascospore formation
  • protein metabolic process
  • peptidyl-prolyl cis-trans isomerase activity
  • FUM1
  • mitochondrial matrix
  • mitochondrion
  • cytosol
  • tricarboxylic acid cycle
  • fumarate metabolic process
  • fumarate hydratase activity
  • PRO1
  • cytoplasm
  • telomere maintenance
  • ribosome biogenesis
  • proline biosynthetic process
  • glutamate 5-kinase activity
  • RAD1
  • nucleotide-excision repair factor 1 complex
  • nucleus
  • nucleotide-excision repair, DNA incision, 5'-to lesion
  • double-strand break repair via single-strand annealing, removal of nonhomologous ends
  • removal of nonhomologous ends
  • meiotic mismatch repair
  • mitotic recombination
  • DNA binding
  • single-stranded DNA specific endodeoxyribonuclease activity
  • RAD10
  • nucleotide-excision repair factor 1 complex
  • nucleus
  • nucleotide-excision repair, DNA incision, 5'-to lesion
  • double-strand break repair via single-strand annealing, removal of nonhomologous ends
  • removal of nonhomologous ends
  • meiotic mismatch repair
  • mitotic recombination
  • DNA strand annealing activity
  • single-stranded DNA specific endodeoxyribonuclease activity
  • single-stranded DNA binding
  • RNR2
  • nucleus
  • cytoplasm
  • ribonucleoside-diphosphate reductase complex
  • DNA replication
  • ribonucleoside-diphosphate reductase activity
  • SAH1
  • cytoplasm
  • methionine metabolic process
  • selenocysteine metabolic process
  • adenosylhomocysteinase activity
  • TFP1
  • vacuolar proton-transporting V-type ATPase, V1 domain
  • fungal-type vacuole membrane
  • protein metabolic process
  • vacuolar acidification
  • intron homing
  • proton-transporting ATPase activity, rotational mechanism
  • endodeoxyribonuclease activity
  • TIF1, TIF2
  • plasma membrane enriched fraction
  • eukaryotic translation initiation factor 4F complex
  • cytoplasm
  • ribosome
  • regulation of translation
  • translational initiation
  • regulation of translational initiation
  • translation
  • nucleotide binding
  • nucleic acid binding
  • translation initiation factor activity
  • ATP binding
  • RNA binding
  • ATP-dependent helicase activity
  • helicase activity
  • ATP-dependent RNA helicase activity
  • hydrolase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleotide-excision repair factor 1 complex 6.8153E-6 10 3 2 6292
    protein complex 4.4574E-4 10 1137 7 6292
    nucleotide-excision repair complex 4.6984E-4 10 21 2 6292
    plasma membrane enriched fraction 1.5893E-3 10 1 1 6292
    macromolecular complex 4.416E-3 10 1635 7 6292
    methionyl glutamyl tRNA synthetase complex 6.3436E-3 10 4 1 6292
    eukaryotic translation initiation factor 4F complex 6.3436E-3 10 4 1 6292
    ribonucleoside-diphosphate reductase complex 6.3436E-3 10 4 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    double-strand break repair via single-strand annealing, removal of nonhomologous ends 2.2737E-6 10 2 2 6292
    nucleotide-excision repair, DNA incision, 5'-to lesion 2.2737E-6 10 2 2 6292
    nucleotide-excision repair, DNA incision 6.8153E-6 10 3 2 6292
    removal of nonhomologous ends 2.2679E-5 10 5 2 6292
    DNA catabolic process, endonucleolytic 3.399E-5 10 6 2 6292
    meiotic mismatch repair 8.1369E-5 10 9 2 6292
    double-strand break repair via single-strand annealing 8.1369E-5 10 9 2 6292
    gene conversion at mating-type locus 1.241E-4 10 11 2 6292
    DNA catabolic process 2.3612E-4 10 15 2 6292
    mating type switching 2.6962E-4 10 16 2 6292
    mating type determination 4.2546E-4 10 20 2 6292
    sex determination 4.2546E-4 10 20 2 6292
    cell fate commitment 5.6509E-4 10 23 2 6292
    DNA recombination 6.3359E-4 10 114 3 6292
    mismatch repair 7.8132E-4 10 27 2 6292
    metabolic process 1.0041E-3 10 3157 10 6292
    reproductive process in single-celled organism 1.0158E-3 10 134 3 6292
    DNA metabolic process 1.1577E-3 10 585 5 6292
    mitotic recombination 1.1694E-3 10 33 2 6292
    non-recombinational repair 1.2414E-3 10 34 2 6292
    carboxylic acid metabolic process 1.2545E-3 10 333 4 6292
    organic acid metabolic process 1.2545E-3 10 333 4 6292
    oxoacid metabolic process 1.2545E-3 10 333 4 6292
    cell differentiation 1.3555E-3 10 148 3 6292
    reproductive developmental process 1.4365E-3 10 151 3 6292
    cellular ketone metabolic process 1.4482E-3 10 346 4 6292
    nucleotide-excision repair 1.5503E-3 10 38 2 6292
    selenocysteine metabolic process 1.5893E-3 10 1 1 6292
    selenium metabolic process 1.5893E-3 10 1 1 6292
    fumarate metabolic process 1.5893E-3 10 1 1 6292
    nucleic acid phosphodiester bond hydrolysis 2.267E-3 10 46 2 6292
    cellular amino acid metabolic process 3.1727E-3 10 199 3 6292
    double-strand break repair 3.4634E-3 10 57 2 6292
    reproductive cellular process 3.747E-3 10 211 3 6292
    reproductive process 3.7975E-3 10 212 3 6292
    reproduction of a single-celled organism 4.0567E-3 10 217 3 6292
    cellular amine metabolic process 4.3266E-3 10 222 3 6292
    proline biosynthetic process 4.7611E-3 10 3 1 6292
    primary metabolic process 5.4001E-3 10 2896 9 6292
    amine metabolic process 5.5806E-3 10 243 3 6292
    cellular amino acid and derivative metabolic process 5.5806E-3 10 243 3 6292
    meiosis I 6.5622E-3 10 79 2 6292
    cellular nitrogen compound metabolic process 7.1615E-3 10 1770 7 6292
    macromolecule metabolic process 7.5629E-3 10 2349 8 6292
    nitrogen compound metabolic process 7.6901E-3 10 1791 7 6292
    cellular metabolic process 7.9165E-3 10 3033 9 6292
    cellular developmental process 7.9625E-3 10 276 3 6292
    intron homing 9.5019E-3 10 6 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    endodeoxyribonuclease activity 4.3833E-6 10 22 3 6292
    deoxyribonuclease activity 1.034E-5 10 29 3 6292
    single-stranded DNA specific endodeoxyribonuclease activity 4.7546E-5 10 7 2 6292
    endonuclease activity 9.9146E-5 10 61 3 6292
    catalytic activity 4.3549E-4 10 2150 9 6292
    trialkylsulfonium hydrolase activity 1.5893E-3 10 1 1 6292
    glutamate 5-kinase activity 1.5893E-3 10 1 1 6292
    fumarate hydratase activity 1.5893E-3 10 1 1 6292
    adenosylhomocysteinase activity 1.5893E-3 10 1 1 6292
    nuclease activity 3.1727E-3 10 199 3 6292
    hydrolase activity, acting on ether bonds 4.7611E-3 10 3 1 6292
    amino acid kinase activity 4.7611E-3 10 3 1 6292
    DNA strand annealing activity 6.3436E-3 10 4 1 6292
    oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor 6.3436E-3 10 4 1 6292
    ribonucleoside-diphosphate reductase activity 6.3436E-3 10 4 1 6292
    oxidoreductase activity, acting on CH or CH2 groups 7.9239E-3 10 5 1 6292
    phosphotransferase activity, carboxyl group as acceptor 7.9239E-3 10 5 1 6292
    tRNA binding 7.9239E-3 10 5 1 6292
    hydrolase activity 8.4227E-3 10 911 5 6292

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