YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Protein Complex Details

Complex Overview

From Publication: Gavin A.C. et al. (2002) Abstract Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature. 2002 Jan 10;415(6868):141-7.
Notes: From the published set of protein complexes.
Complex Size: 18 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
ABD1
  • nucleus
  • DNA-directed RNA polymerase II, holoenzyme
    		•
  • mRNA capping
    		•
  • mRNA (guanine-N7-)-methyltransferase activity
    		•
    AOS1
  • nucleus
    		•
  • protein sumoylation
    		•
  • SUMO activating enzyme activity
    		•
    IWR1
  • nucleus
  • cytoplasm
  • DNA-directed RNA polymerase II, holoenzyme
    		•
  • transcription from RNA polymerase II promoter
  • meiosis
    		•
  • molecular_function
    		•
    RPB11
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPB2
  • mitochondrion
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPB3
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPB4
  • nucleus
  • cytoplasm
  • cytoplasmic mRNA processing body
  • DNA-directed RNA polymerase II, core complex
    		•
  • mRNA export from nucleus
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPB5
  • DNA-directed RNA polymerase I complex
  • DNA-directed RNA polymerase III complex
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase III promoter
  • transcription from RNA polymerase I promoter
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPB7
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPB8
  • DNA-directed RNA polymerase I complex
  • DNA-directed RNA polymerase III complex
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase III promoter
  • transcription from RNA polymerase I promoter
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPB9
  • DNA-directed RNA polymerase II, core complex
    		•
  • response to drug
  • transcription-coupled nucleotide-excision repair
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • response to DNA damage stimulus
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPO21
  • mitochondrion
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPO26
  • DNA-directed RNA polymerase I complex
  • DNA-directed RNA polymerase III complex
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase III promoter
  • transcription from RNA polymerase I promoter
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    SPT4
  • nucleus
  • transcription elongation factor complex
  • DSIF complex
  • kinetochore
  • nuclear chromosome, telomeric region
    		•
  • regulation of transcription, DNA-dependent
  • chromosome segregation
  • chromatin silencing
  • chromatin organization
  • RNA elongation from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription elongation factor activity
    		•
    SPT5
  • nucleus
  • transcription elongation factor complex
  • DSIF complex
  • mitochondrion
    		•
  • regulation of transcription, DNA-dependent
  • chromatin organization
  • RNA elongation from RNA polymerase II promoter
    		•
  • RNA polymerase II transcription elongation factor activity
    		•
    TAF14
  • SWI/SNF complex
  • transcription factor TFIID complex
  • Ino80 complex
  • transcription factor TFIIF complex
  • histone acetyltransferase complex
    		•
  • chromatin remodeling
  • regulation of transcription involved in G1 phase of mitotic cell cycle
  • transcription initiation from RNA polymerase II promoter
    		•
  • general RNA polymerase II transcription factor activity
    		•
    TFG1
  • transcription factor TFIIF complex
    		•
  • transcription initiation from RNA polymerase II promoter
    		•
  • general RNA polymerase II transcription factor activity
    		•
    TFG2
  • transcription factor TFIIF complex
    		•
  • transcription initiation from RNA polymerase II promoter
    		•
  • general RNA polymerase II transcription factor activity
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    DNA-directed RNA polymerase II, holoenzyme 1.8053E-29 18 56 15 6292
    DNA-directed RNA polymerase II, core complex 1.0829E-25 18 12 10 6292
    nucleoplasm part 1.0946E-23 18 245 17 6292
    nucleoplasm 4.0507E-23 18 264 17 6292
    DNA-directed RNA polymerase complex 7.1183E-20 18 31 10 6292
    RNA polymerase complex 7.1183E-20 18 31 10 6292
    nuclear DNA-directed RNA polymerase complex 7.1183E-20 18 31 10 6292
    nuclear lumen 4.7583E-19 18 453 17 6292
    organelle lumen 3.0413E-16 18 660 17 6292
    intracellular organelle lumen 3.0413E-16 18 660 17 6292
    membrane-enclosed lumen 8.3132E-16 18 700 17 6292
    nuclear part 1.8955E-12 18 1103 17 6292
    protein complex 3.1682E-12 18 1137 17 6292
    macromolecular complex 1.4375E-9 18 1635 17 6292
    nucleus 1.5028E-9 18 2041 18 6292
    transcription factor TFIIF complex 1.9664E-8 18 3 3 6292
    intracellular organelle part 3.7122E-7 18 2282 17 6292
    organelle part 3.7122E-7 18 2282 17 6292
    DNA-directed RNA polymerase I complex 7.0183E-6 18 14 3 6292
    DSIF complex 7.7306E-6 18 2 2 6292
    DNA-directed RNA polymerase III complex 1.3041E-5 18 17 3 6292
    membrane-bounded organelle 9.7936E-5 18 3771 18 6292
    intracellular membrane-bounded organelle 9.7936E-5 18 3771 18 6292
    nucleolar part 2.5882E-4 18 45 3 6292
    intracellular organelle 3.879E-4 18 4070 18 6292
    organelle 3.8963E-4 18 4071 18 6292
    transcription factor complex 9.9506E-4 18 71 3 6292
    transcription elongation factor complex 1.8874E-3 18 23 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    transcription from RNA polymerase II promoter 4.0971E-19 18 335 16 6292
    transcription, DNA-dependent 2.9302E-16 18 503 16 6292
    RNA biosynthetic process 3.4353E-16 18 508 16 6292
    transcription 1.3041E-15 18 552 16 6292
    RNA metabolic process 1.6192E-13 18 954 17 6292
    gene expression 2.4382E-11 18 1283 17 6292
    nucleic acid metabolic process 1.2694E-10 18 1415 17 6292
    cellular macromolecule biosynthetic process 2.4649E-10 18 1187 16 6292
    macromolecule biosynthetic process 2.5308E-10 18 1189 16 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 6.9757E-10 18 1566 17 6292
    cellular nitrogen compound metabolic process 5.4238E-9 18 1770 17 6292
    nitrogen compound metabolic process 6.6055E-9 18 1791 17 6292
    cellular macromolecule metabolic process 1.1566E-8 18 2285 18 6292
    cellular biosynthetic process 1.8632E-8 18 1567 16 6292
    macromolecule metabolic process 1.9051E-8 18 2349 18 6292
    biosynthetic process 2.6214E-8 18 1602 16 6292
    primary metabolic process 8.3514E-7 18 2896 18 6292
    cellular metabolic process 1.9237E-6 18 3033 18 6292
    metabolic process 3.9649E-6 18 3157 18 6292
    transcription from RNA polymerase I promoter 7.607E-5 18 30 3 6292
    transcription from RNA polymerase III promoter 1.5581E-4 18 38 3 6292
    transcription initiation from RNA polymerase II promoter 2.947E-4 18 47 3 6292
    transcription initiation 5.4986E-4 18 58 3 6292
    cellular process 1.7601E-3 18 4426 18 6292
    RNA elongation from RNA polymerase II promoter 5.3803E-3 18 39 2 6292
    transcription-coupled nucleotide-excision repair 5.7138E-3 18 2 1 6292
    RNA elongation 7.1157E-3 18 45 2 6292
    mRNA capping 8.5592E-3 18 3 1 6292
    protein complex biogenesis 9.1171E-3 18 155 3 6292
    protein complex assembly 9.1171E-3 18 155 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    RNA polymerase activity 2.0972E-19 18 34 10 6292
    DNA-directed RNA polymerase activity 2.0972E-19 18 34 10 6292
    nucleotidyltransferase activity 5.1338E-12 18 168 10 6292
    transferase activity, transferring phosphorus-containing groups 4.2626E-8 18 420 10 6292
    transferase activity 1.7232E-6 18 797 11 6292
    RNA polymerase II transcription elongation factor activity 5.9184E-4 18 13 2 6292
    general RNA polymerase II transcription factor activity 7.3452E-4 18 64 3 6292
    transcription elongation regulator activity 1.2844E-3 18 19 2 6292
    transcription regulator activity 2.1089E-3 18 339 5 6292
    mRNA (guanine-N7-)-methyltransferase activity 2.8608E-3 18 1 1 6292
    catalytic activity 4.886E-3 18 2150 12 6292
    RNA polymerase II transcription factor activity 5.604E-3 18 130 3 6292
    SUMO activating enzyme activity 5.7138E-3 18 2 1 6292
    mRNA methyltransferase activity 5.7138E-3 18 2 1 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle