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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 27 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
BDP1
  • transcription factor TFIIIB complex
    		•
  • transcription initiation from RNA polymerase III promoter
    		•
  • RNA polymerase III transcription factor activity
    		•
    CDC14
  • nucleus
  • RENT complex
  • spindle pole body
  • nucleolus
    		•
  • regulation of exit from mitosis
  • protein amino acid dephosphorylation
    		•
  • phosphoprotein phosphatase activity
    		•
    COY1
  • Golgi membrane
    		•
  • Golgi vesicle transport
    		•
  • molecular_function
    		•
    FAR7
  • cellular_component
    		•
  • cell cycle arrest in response to pheromone
    		•
  • molecular_function
    		•
    MAF1
  • nucleus
    		•
  • negative regulation of transcription from RNA polymerase III promoter
    		•
  • transcription regulator activity
    		•
    RET1
  • DNA-directed RNA polymerase III complex
    		•
  • transcription from RNA polymerase III promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPA12
  • DNA-directed RNA polymerase I complex
    		•
  • transcription from RNA polymerase I promoter
  • ribosome biogenesis
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPA135
  • DNA-directed RNA polymerase I complex
    		•
  • transcription from RNA polymerase I promoter
  • ribosome biogenesis
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPA14
  • DNA-directed RNA polymerase I complex
    		•
  • transcription from RNA polymerase I promoter
  • regulation of cell size
  • telomere maintenance
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPA190
  • DNA-directed RNA polymerase I complex
    		•
  • transcription from RNA polymerase I promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPA34
  • nucleus
  • DNA-directed RNA polymerase I complex
  • nucleolus
    		•
  • transcription from RNA polymerase I promoter
  • ribosome biogenesis
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPA43
  • DNA-directed RNA polymerase I complex
    		•
  • transcription from RNA polymerase I promoter
  • ribosome biogenesis
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPA49
  • DNA-directed RNA polymerase I complex
    		•
  • transcription from RNA polymerase I promoter
  • regulation of cell size
  • ribosome biogenesis
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPC10
  • DNA-directed RNA polymerase I complex
  • DNA-directed RNA polymerase III complex
  • DNA-directed RNA polymerase II, core complex
    		•
  • transcription from RNA polymerase III promoter
  • transcription from RNA polymerase I promoter
  • transcription from RNA polymerase II promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPC11
  • DNA-directed RNA polymerase III complex
    		•
  • transcription from RNA polymerase III promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPC17
  • DNA-directed RNA polymerase III complex
    		•
  • transcription initiation from RNA polymerase III promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPC19
  • DNA-directed RNA polymerase I complex
  • DNA-directed RNA polymerase III complex
    		•
  • transcription from RNA polymerase III promoter
  • transcription from RNA polymerase I promoter
  • ribosome biogenesis
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPC25
  • DNA-directed RNA polymerase III complex
    		•
  • transcription from RNA polymerase III promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPC31
  • DNA-directed RNA polymerase III complex
    		•
  • transcription from RNA polymerase III promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPC34
  • nucleus
  • cytoplasm
  • mitochondrion
  • DNA-directed RNA polymerase III complex
    		•
  • transcription from RNA polymerase III promoter
  • ribosome biogenesis
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPC37
  • DNA-directed RNA polymerase III complex
    		•
  • transcription from RNA polymerase III promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPC40
  • DNA-directed RNA polymerase I complex
  • DNA-directed RNA polymerase III complex
    		•
  • transcription from RNA polymerase III promoter
  • transcription from RNA polymerase I promoter
  • ribosome biogenesis
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPC53
  • DNA-directed RNA polymerase III complex
    		•
  • transcription from RNA polymerase III promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPC82
  • DNA-directed RNA polymerase III complex
    		•
  • transcription from RNA polymerase III promoter
  • ribosome biogenesis
    		•
  • DNA-directed RNA polymerase activity
    		•
    RPO31
  • DNA-directed RNA polymerase III complex
    		•
  • transcription from RNA polymerase III promoter
    		•
  • DNA-directed RNA polymerase activity
    		•
    YDL144C
  • nucleus
  • cytoplasm
    		•
  • biological_process
    		•
  • molecular_function
    		•
    YIR024C
  • mitochondrion
    		•
  • biological_process
    		•
  • molecular_function
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    DNA-directed RNA polymerase complex 1.9704E-44 27 31 20 6292
    RNA polymerase complex 1.9704E-44 27 31 20 6292
    nuclear DNA-directed RNA polymerase complex 1.9704E-44 27 31 20 6292
    DNA-directed RNA polymerase III complex 1.2322E-29 27 17 13 6292
    DNA-directed RNA polymerase I complex 3.1426E-22 27 14 10 6292
    nuclear lumen 2.5767E-21 27 453 22 6292
    nucleolar part 8.0423E-18 27 45 11 6292
    organelle lumen 1.0083E-17 27 660 22 6292
    intracellular organelle lumen 1.0083E-17 27 660 22 6292
    membrane-enclosed lumen 3.6303E-17 27 700 22 6292
    nucleoplasm part 1.6301E-13 27 245 14 6292
    nucleoplasm 4.5906E-13 27 264 14 6292
    nuclear part 6.3623E-13 27 1103 22 6292
    protein complex 1.2104E-12 27 1137 22 6292
    nucleolus 3.7894E-10 27 211 11 6292
    nucleus 1.6235E-9 27 2041 24 6292
    macromolecular complex 2.3591E-9 27 1635 22 6292
    intracellular organelle part 2.2271E-7 27 2282 23 6292
    organelle part 2.2271E-7 27 2282 23 6292
    membrane-bounded organelle 1.8345E-5 27 3771 26 6292
    intracellular membrane-bounded organelle 1.8345E-5 27 3771 26 6292
    intracellular organelle 1.197E-4 27 4070 26 6292
    organelle 1.2042E-4 27 4071 26 6292
    non-membrane-bounded organelle 1.2072E-3 27 959 11 6292
    intracellular non-membrane-bounded organelle 1.2072E-3 27 959 11 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    transcription from RNA polymerase III promoter 3.5781E-28 27 38 15 6292
    transcription, DNA-dependent 2.608E-20 27 503 22 6292
    RNA biosynthetic process 3.2437E-20 27 508 22 6292
    transcription 2.0188E-19 27 552 22 6292
    transcription from RNA polymerase I promoter 9.0675E-18 27 30 10 6292
    RNA metabolic process 2.8897E-14 27 954 22 6292
    cellular macromolecule biosynthetic process 3.0051E-12 27 1187 22 6292
    macromolecule biosynthetic process 3.1137E-12 27 1189 22 6292
    gene expression 1.543E-11 27 1283 22 6292
    nucleic acid metabolic process 1.1931E-10 27 1415 22 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 9.7289E-10 27 1566 22 6292
    cellular biosynthetic process 9.8576E-10 27 1567 22 6292
    biosynthetic process 1.5526E-9 27 1602 22 6292
    cellular nitrogen compound metabolic process 1.19E-8 27 1770 22 6292
    nitrogen compound metabolic process 1.5116E-8 27 1791 22 6292
    cellular macromolecule metabolic process 2.2894E-7 27 2285 23 6292
    macromolecule metabolic process 4.0823E-7 27 2349 23 6292
    ribosome biogenesis 8.034E-6 27 346 9 6292
    ribonucleoprotein complex biogenesis 1.5129E-5 27 374 9 6292
    primary metabolic process 2.9566E-5 27 2896 23 6292
    cellular component biogenesis 6.7144E-5 27 694 11 6292
    cellular metabolic process 7.3894E-5 27 3033 23 6292
    metabolic process 1.6171E-4 27 3157 23 6292
    transcription initiation from RNA polymerase III promoter 9.5242E-4 27 11 2 6292
    negative regulation of transcription from RNA polymerase III promoter 4.2912E-3 27 1 1 6292
    cellular process 5.5321E-3 27 4426 25 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    RNA polymerase activity 3.229E-43 27 34 20 6292
    DNA-directed RNA polymerase activity 3.229E-43 27 34 20 6292
    nucleotidyltransferase activity 8.1563E-27 27 168 20 6292
    transferase activity, transferring phosphorus-containing groups 1.15E-18 27 420 20 6292
    transferase activity 3.3813E-13 27 797 20 6292
    catalytic activity 4.2867E-6 27 2150 21 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle