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Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 13 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
ADA2
  • SLIK (SAGA-like) complex
  • Ada2/Gcn5/Ada3 transcription activator complex
  • SAGA complex
    		•
  • chromatin modification
  • histone acetylation
    		•
  • transcription coactivator activity
    		•
    GCN5
  • SLIK (SAGA-like) complex
  • Ada2/Gcn5/Ada3 transcription activator complex
  • SAGA complex
    		•
  • chromatin modification
  • histone acetylation
    		•
  • histone acetyltransferase activity
  • transcription coactivator activity
    		•
    HFI1
  • SLIK (SAGA-like) complex
  • Ada2/Gcn5/Ada3 transcription activator complex
  • SAGA complex
    		•
  • chromatin modification
  • telomere maintenance
  • transcription from RNA polymerase II promoter
  • histone acetylation
    		•
  • transcription cofactor activity
  • transcription coactivator activity
    		•
    NGG1
  • SLIK (SAGA-like) complex
  • Ada2/Gcn5/Ada3 transcription activator complex
  • SAGA complex
    		•
  • chromatin modification
  • response to drug
  • histone acetylation
    		•
  • transcription cofactor activity
    		•
    SGF29
  • SAGA complex
    		•
  • histone acetylation
    		•
  • molecular_function
    		•
    SGF73
  • SLIK (SAGA-like) complex
  • SAGA complex
    		•
  • chromatin modification
  • histone acetylation
    		•
  • histone acetyltransferase activity
  • structural molecule activity
    		•
    SPT20
  • SLIK (SAGA-like) complex
  • SAGA complex
    		•
  • chromatin modification
  • histone acetylation
    		•
  • transcription cofactor activity
    		•
    SPT3
  • SLIK (SAGA-like) complex
  • SAGA complex
    		•
  • chromatin modification
  • ascospore formation
  • conjugation with cellular fusion
  • pseudohyphal growth
  • histone acetylation
  • invasive growth in response to glucose limitation
    		•
  • transcription cofactor activity
    		•
    SPT7
  • SLIK (SAGA-like) complex
  • mitochondrion
  • SAGA complex
    		•
  • chromatin modification
  • protein complex assembly
  • conjugation with cellular fusion
  • histone acetylation
    		•
  • structural molecule activity
    		•
    SPT8
  • nucleus
  • SAGA complex
    		•
  • negative regulation of transcription from RNA polymerase II promoter
  • positive regulation of transcription from RNA polymerase II promoter
    		•
  • transcription cofactor activity
  • TATA-binding protein binding
    		•
    TAF5
  • transcription factor TFIID complex
  • SLIK (SAGA-like) complex
  • SAGA complex
    		•
  • chromatin modification
  • protein amino acid acetylation
  • histone acetylation
  • chromatin organization
  • regulation of transcription involved in G1 phase of mitotic cell cycle
  • transcription initiation from RNA polymerase II promoter
    		•
  • general RNA polymerase II transcription factor activity
    		•
    TAF6
  • transcription factor TFIID complex
  • SLIK (SAGA-like) complex
  • SAGA complex
    		•
  • chromatin modification
  • protein amino acid acetylation
  • histone acetylation
  • chromatin organization
  • regulation of transcription involved in G1 phase of mitotic cell cycle
  • transcription initiation from RNA polymerase II promoter
    		•
  • general RNA polymerase II transcription factor activity
    		•
    TRA1
  • NuA4 histone acetyltransferase complex
  • SLIK (SAGA-like) complex
  • SAGA complex
  • histone acetyltransferase complex
    		•
  • DNA repair
  • histone acetylation
  • regulation of transcription from RNA polymerase II promoter
    		•
  • histone acetyltransferase activity
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    SAGA complex 1.2946E-34 13 22 13 6292
    SAGA-type complex 2.9776E-34 13 23 13 6292
    histone acetyltransferase complex 1.3512E-29 13 44 13 6292
    SLIK (SAGA-like) complex 2.2388E-29 13 16 11 6292
    nucleoplasm part 3.4643E-19 13 245 13 6292
    nucleoplasm 9.3669E-19 13 264 13 6292
    nuclear lumen 1.1883E-15 13 453 13 6292
    organelle lumen 1.6732E-13 13 660 13 6292
    intracellular organelle lumen 1.6732E-13 13 660 13 6292
    membrane-enclosed lumen 3.6201E-13 13 700 13 6292
    Ada2/Gcn5/Ada3 transcription activator complex 5.4733E-11 13 5 4 6292
    nuclear part 1.3925E-10 13 1103 13 6292
    protein complex 2.0707E-10 13 1137 13 6292
    macromolecular complex 2.3774E-8 13 1635 13 6292
    nucleus 4.29E-7 13 2041 13 6292
    organelle part 1.8381E-6 13 2282 13 6292
    intracellular organelle part 1.8381E-6 13 2282 13 6292
    transcription factor TFIID complex 4.0759E-4 13 15 2 6292
    membrane-bounded organelle 1.2767E-3 13 3771 13 6292
    intracellular membrane-bounded organelle 1.2767E-3 13 3771 13 6292
    intracellular organelle 3.4477E-3 13 4070 13 6292
    organelle 3.4587E-3 13 4071 13 6292
    DNA-directed RNA polymerase II, holoenzyme 5.699E-3 13 56 2 6292
    transcription factor complex 9.0369E-3 13 71 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    histone acetylation 2.0386E-27 13 36 12 6292
    protein amino acid acetylation 6.328E-26 13 46 12 6292
    protein amino acid acylation 1.8171E-24 13 59 12 6292
    covalent chromatin modification 3.3192E-22 13 88 12 6292
    histone modification 3.3192E-22 13 88 12 6292
    chromatin modification 1.1273E-18 13 168 12 6292
    chromatin organization 1.1659E-17 13 203 12 6292
    post-translational protein modification 1.1516E-14 13 357 12 6292
    protein modification process 6.6084E-13 13 499 12 6292
    chromosome organization 2.3792E-12 13 555 12 6292
    macromolecule modification 3.2105E-12 13 569 12 6292
    cellular protein metabolic process 6.3767E-9 13 1074 12 6292
    organelle organization 1.1295E-8 13 1127 12 6292
    protein metabolic process 1.2412E-8 13 1136 12 6292
    cellular component organization 6.186E-7 13 1582 12 6292
    cellular macromolecule metabolic process 1.8698E-6 13 2285 13 6292
    macromolecule metabolic process 2.6802E-6 13 2349 13 6292
    primary metabolic process 4.1002E-5 13 2896 13 6292
    cellular metabolic process 7.4867E-5 13 3033 13 6292
    metabolic process 1.2617E-4 13 3157 13 6292
    regulation of transcription involved in G1 phase of mitotic cell cycle 3.5365E-4 13 14 2 6292
    transcription from RNA polymerase II promoter 3.748E-4 13 335 5 6292
    regulation of transcription from RNA polymerase II promoter 9.2751E-4 13 228 4 6292
    G1 phase 1.3436E-3 13 27 2 6292
    G1 phase of mitotic cell cycle 1.3436E-3 13 27 2 6292
    transcription, DNA-dependent 2.3984E-3 13 503 5 6292
    RNA biosynthetic process 2.5064E-3 13 508 5 6292
    protein complex biogenesis 3.4971E-3 13 155 3 6292
    protein complex assembly 3.4971E-3 13 155 3 6292
    transcription 3.6199E-3 13 552 5 6292
    transcription initiation from RNA polymerase II promoter 4.0426E-3 13 47 2 6292
    regulation of transcription, DNA-dependent 4.8872E-3 13 358 4 6292
    regulation of RNA metabolic process 5.1368E-3 13 363 4 6292
    transcription initiation 6.103E-3 13 58 2 6292
    regulation of transcription 6.2808E-3 13 384 4 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 8.2693E-3 13 415 4 6292
    regulation of nitrogen compound metabolic process 8.3397E-3 13 416 4 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    transcription cofactor activity 4.0309E-13 13 40 7 6292
    transcription factor binding 6.9497E-13 13 43 7 6292
    transcription regulator activity 2.0366E-9 13 339 9 6292
    histone acetyltransferase activity 4.609E-6 13 17 3 6292
    lysine N-acetyltransferase activity 4.609E-6 13 17 3 6292
    transcription coactivator activity 8.9718E-6 13 21 3 6292
    N-acetyltransferase activity 3.6281E-5 13 33 3 6292
    N-acyltransferase activity 5.5762E-5 13 38 3 6292
    protein binding 8.0963E-5 13 612 7 6292
    acetyltransferase activity 1.2771E-4 13 50 3 6292
    transcription activator activity 2.3144E-4 13 61 3 6292
    transferase activity, transferring acyl groups other than amino-acyl groups 7.7815E-4 13 92 3 6292
    acyltransferase activity 7.7815E-4 13 92 3 6292
    transferase activity, transferring acyl groups 1.208E-3 13 107 3 6292
    TATA-binding protein binding 4.1283E-3 13 2 1 6292
    general RNA polymerase II transcription factor activity 7.3913E-3 13 64 2 6292
    binding 8.1545E-3 13 1294 7 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle