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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 20 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • DBP10
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • DRS1
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • ERB1
  • nucleus
  • nucleolus
  • rRNA processing
  • molecular_function
  • HAS1
  • nuclear envelope
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
  • MAK21
  • Noc1p-Noc2p complex
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • molecular_function
  • NIP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • rRNA processing
  • ribosomal large subunit assembly
  • molecular_function
  • NOC2
  • nucleus
  • Noc2p-Noc3p complex
  • mitochondrion
  • Noc1p-Noc2p complex
  • ribosomal subunit export from nucleus
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • GTP binding
  • NOP15
  • nucleus
  • nucleolus
  • cytokinesis, actomyosin contractile ring assembly
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
  • NOP4
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • NOP7
  • nucleus
  • nucleolus
  • cell proliferation
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • cell cycle
  • molecular_function
  • NSA1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • NUG1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • GTPase activity
  • PUF6
  • nucleus
  • nucleolus
  • regulation of transcription, mating-type specific
  • ribosome biogenesis
  • mRNA binding
  • specific transcriptional repressor activity
  • RLP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • rRNA binding
  • RPF1
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • processing of 27S pre-rRNA
  • rRNA primary transcript binding
  • TIF6
  • nucleus
  • cytoplasm
  • nuclear outer membrane
  • nucleolus
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • processing of 27S pre-rRNA
  • ribosomal large subunit binding
  • YTM1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 1.3161E-30 20 211 20 6292
    nuclear lumen 9.4296E-24 20 453 20 6292
    organelle lumen 2.0043E-20 20 660 20 6292
    intracellular organelle lumen 2.0043E-20 20 660 20 6292
    membrane-enclosed lumen 6.6119E-20 20 700 20 6292
    non-membrane-bounded organelle 3.8645E-17 20 959 20 6292
    intracellular non-membrane-bounded organelle 3.8645E-17 20 959 20 6292
    nuclear part 6.5104E-16 20 1103 20 6292
    nucleus 1.5619E-10 20 2041 20 6292
    intracellular organelle part 1.4703E-9 20 2282 20 6292
    organelle part 1.4703E-9 20 2282 20 6292
    preribosome, large subunit precursor 2.2798E-6 20 9 3 6292
    Noc1p-Noc2p complex 9.6001E-6 20 2 2 6292
    membrane-bounded organelle 3.504E-5 20 3771 20 6292
    intracellular membrane-bounded organelle 3.504E-5 20 3771 20 6292
    Noc complex 9.5453E-5 20 5 2 6292
    nuclear outer membrane 1.3339E-4 20 86 4 6292
    preribosome 1.5437E-4 20 34 3 6292
    intracellular organelle 1.6178E-4 20 4070 20 6292
    organelle 1.6258E-4 20 4071 20 6292
    nuclear membrane 2.128E-4 20 97 4 6292
    nuclear envelope 3.1661E-4 20 199 5 6292
    90S preribosome 1.2688E-3 20 17 2 6292
    outer membrane 2.1034E-3 20 178 4 6292
    organelle outer membrane 2.1034E-3 20 178 4 6292
    nuclear membrane-endoplasmic reticulum network 5.476E-3 20 232 4 6292
    Noc2p-Noc3p complex 6.3477E-3 20 2 1 6292
    endomembrane system 6.9334E-3 20 398 5 6292
    intracellular part 7.7919E-3 20 4938 20 6292
    nucleolar part 8.7567E-3 20 45 2 6292
    intracellular 9.0491E-3 20 4975 20 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribosome biogenesis 3.7651E-26 20 346 20 6292
    ribonucleoprotein complex biogenesis 1.863E-25 20 374 20 6292
    ribosomal large subunit biogenesis 3.1387E-22 20 65 13 6292
    cellular component biogenesis 5.5528E-20 20 694 20 6292
    ribosome assembly 5.6238E-10 20 64 7 6292
    organelle assembly 9.6785E-10 20 69 7 6292
    ribonucleoprotein complex assembly 7.5356E-9 20 92 7 6292
    rRNA processing 7.6117E-8 20 128 7 6292
    rRNA metabolic process 1.2182E-7 20 137 7 6292
    ribosomal large subunit assembly 1.318E-7 20 41 5 6292
    ribosomal subunit assembly 5.9497E-7 20 55 5 6292
    cellular macromolecular complex assembly 8.5132E-7 20 182 7 6292
    ncRNA processing 2.6182E-6 20 215 7 6292
    ncRNA metabolic process 8.5827E-6 20 257 7 6292
    cellular macromolecular complex subunit organization 9.0334E-6 20 259 7 6292
    processing of 27S pre-rRNA 1.4984E-5 20 16 3 6292
    macromolecular complex assembly 1.5441E-5 20 281 7 6292
    establishment of ribosome localization 6.8171E-5 20 26 3 6292
    ribosome localization 6.8171E-5 20 26 3 6292
    ribosomal subunit export from nucleus 6.8171E-5 20 26 3 6292
    macromolecular complex subunit organization 7.2694E-5 20 357 7 6292
    RNA processing 1.0815E-4 20 380 7 6292
    cellular component assembly 1.1749E-4 20 385 7 6292
    establishment of organelle localization 6.4857E-4 20 55 3 6292
    obsolete_biological_process 8.3744E-4 20 60 3 6292
    cellular process 8.6878E-4 20 4426 20 6292
    organelle localization 2.2977E-3 20 85 3 6292
    nuclear export 3.9666E-3 20 103 3 6292
    RNA metabolic process 6.2445E-3 20 954 8 6292
    nuclear transport 7.5971E-3 20 130 3 6292
    nucleocytoplasmic transport 7.5971E-3 20 130 3 6292
    actomyosin structure organization 9.5071E-3 20 3 1 6292
    cytokinesis, actomyosin contractile ring assembly 9.5071E-3 20 3 1 6292
    assembly of actomyosin apparatus involved in cell cycle cytokinesis 9.5071E-3 20 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ATP-dependent RNA helicase activity 8.5548E-5 20 28 3 6292
    RNA-dependent ATPase activity 9.5225E-5 20 29 3 6292
    RNA helicase activity 2.9139E-4 20 42 3 6292
    ATP-dependent helicase activity 4.337E-4 20 48 3 6292
    purine NTP-dependent helicase activity 4.337E-4 20 48 3 6292
    rRNA binding 1.1216E-3 20 16 2 6292
    helicase activity 2.1461E-3 20 83 3 6292
    ribosomal large subunit binding 3.1786E-3 20 1 1 6292
    RNA binding 4.9144E-3 20 367 5 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle