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Protein Overview: AHP1

General Information:
Name(s) found: AHP1 / YLR109W [SGD]
Description(s) found:
Found 32 descriptions.
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  • Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 176 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: response to oxidative stress [IGILink to PubMed article]
    response to metal ion [IMPLink to PubMed article]
    Molecular Function: thioredoxin peroxidase activity [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDLVNKKFP AGDYKFQYIA ISQSDADSES CKMPQTVEWS KLISENKKVI ITGAPAAFSP  60
   61 TCTVSHIPGY INYLDELVKE KEVDQVIVVT VDNPFANQAW AKSLGVKDTT HIKFASDPGC 120
  121 AFTKSIGFEL AVGDGVYWSG RWAMVVENGI VTYAAKETNP GTDVTVSSVE SVLAHL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) AHP1 HYP2
    View Details Krogan NJ, et al. (2006) AHP1 MRT4 SSB2
    View Details Ho Y, et al. (2002) AAC3 AAT2 ACH1 ACO1 ADH2 AFR1 AHA1 AHP1 ARC1 ARF1 ATP3 CAR2 CDC16 CDC33 CDC39 CLU1 COF1 COR1 CPR1 CYR1 CYS4 DCS1 DCS2 DNL4 DUN1 EGD1 ERG13 ERG20 ERG6 FOL2 FPR1 FRS2 GCD11 GDB1 GND1 GND2 GPG1 GRX1 GUS1 HEF3 HHF1, HHF2 HHT1, HHT2 HTB1 HXT7 HYP2 ILV5 LHS1 LIF1 LRO1 LSP1 MEC3 MET6 MGE1 MGT1 MNP1 MPC54 MRE11 NMD3 NTF2 OLA1 OYE2 OYE3 PFK1 PIL1 POR1 PRM2 PST2 PYC2 RAD50 RFA2 RGI1 RIP1 RNR2 RPP0 RSN1 RTC3 SAH1 SCP160 SEC27 SEC53 SEN15 SES1 SNU13 SOD1 SOF1 TEF4 THS1 TIF1, TIF2 TIF6 TMA19 TSA2 UBA1 UBC7 UBI4 UBP15 UBR1 VMA4 VMA5 VPS1 WTM1 XRS2 YAK1 YBL108W YCK1 YHR033W YHR112C YLR241W YNK1 YPL247C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run KOG1 No Comments Reinke A, et al. (2004)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #08 Alpha Factor Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data AHP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..176] PSI-BLAST 121.770868 Peroxiredoxin 5

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • antioxidant activity
    		•  3.26520127994042 bayes_pls_golite062009
  • peroxidase activity
    		•  3.04028765378214 bayes_pls_golite062009
  • oxidoreductase activity, acting on peroxide as acceptor
    		•  3.04028765378214 bayes_pls_golite062009
  • peroxiredoxin activity
    		•  2.12777217096121 bayes_pls_golite062009
  • glutathione peroxidase activity
    		•  2.012364779649 bayes_pls_golite062009
  • selenium binding
    		•  1.97951129054219 bayes_pls_golite062009
  • thioredoxin peroxidase activity
    		•  1.96134566495756 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  1.8187537496904 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  1.32811008894503 bayes_pls_golite062009
  • hydrolase activity
    		•  1.22195225405134 bayes_pls_golite062009
  • peptidase activity
    		•  0.883522845958727 bayes_pls_golite062009
  • phospholipid-hydroperoxide glutathione peroxidase activity
    		•  0.874146425427531 bayes_pls_golite062009
  • binding
    		•  0.828696005067827 bayes_pls_golite062009
  • catalytic activity
    		•  0.672192331361968 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.633952012887619 bayes_pls_golite062009
  • endopeptidase activity
    		•  0.221581298285454 bayes_pls_golite062009
  • alkyl hydroperoxide reductase activity
    		•  0.21601252862268 bayes_pls_golite062009
  • intramolecular oxidoreductase activity
    		•  0.13913802190798 bayes_pls_golite062009
  • protein binding
    		•  0.134341907247724 bayes_pls_golite062009
  • protein disulfide oxidoreductase activity
    		•  0.0719543694089202 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle