YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Gavin A.C. et al. (2002) Abstract Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature. 2002 Jan 10;415(6868):141-7.
Notes:	From the published set of protein complexes.
Complex Size:	36 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
ASC1	cytoplasm	telomere maintenance negative regulation of translation	molecular_function
CDC33	nucleus eukaryotic translation initiation factor 4F complex cytoplasm ribosome	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay translational initiation	translation initiation factor activity
CLF1	chromatin	DNA replication cell cycle cis assembly of pre-catalytic spliceosome nuclear mRNA splicing, via spliceosome	protein binding
CWC23	spliceosomal complex	biological_process	molecular_function
DCP2	nucleus cytoplasm cytoplasmic mRNA processing body	deadenylation-independent decapping of nuclear-transcribed mRNA deadenylation-dependent decapping of nuclear-transcribed mRNA mRNA catabolic process	mRNA binding m7G(5')pppN diphosphatase activity hydrolase activity
DHH1	cytoplasm cytoplasmic mRNA processing body	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay deadenylation-dependent decapping of nuclear-transcribed mRNA	protein binding RNA helicase activity
DIB1	U4/U6 x U5 tri-snRNP complex U5 snRNP	nuclear mRNA splicing, via spliceosome	molecular_function
ERB1	nucleus nucleolus	rRNA processing	molecular_function
KRS1	cytoplasm	lysyl-tRNA aminoacylation	lysine-tRNA ligase activity
LSM1	mRNA cap binding complex cytoplasmic mRNA processing body	deadenylation-dependent decapping of nuclear-transcribed mRNA mRNA catabolic process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	RNA binding RNA cap binding
LSM2	U4/U6 x U5 tri-snRNP complex nucleolus U6 snRNP small nucleolar ribonucleoprotein complex	mRNA catabolic process nuclear mRNA splicing, via spliceosome	RNA binding
LSM3	U4/U6 x U5 tri-snRNP complex nucleolus U6 snRNP small nucleolar ribonucleoprotein complex	mRNA catabolic process nuclear mRNA splicing, via spliceosome	RNA binding
LSM4	U4/U6 x U5 tri-snRNP complex nucleolus U6 snRNP small nucleolar ribonucleoprotein complex	mRNA catabolic process nuclear mRNA splicing, via spliceosome	RNA binding
LSM5	U4/U6 x U5 tri-snRNP complex nucleolus U6 snRNP small nucleolar ribonucleoprotein complex	mRNA catabolic process nuclear mRNA splicing, via spliceosome	RNA binding
LSM6	U4/U6 x U5 tri-snRNP complex nucleolus U6 snRNP small nucleolar ribonucleoprotein complex	mRNA catabolic process nuclear mRNA splicing, via spliceosome	RNA binding
LSM7	U4/U6 x U5 tri-snRNP complex nucleolus U6 snRNP small nucleolar ribonucleoprotein complex	telomere maintenance mRNA catabolic process nuclear mRNA splicing, via spliceosome	RNA binding
NAM7	polysome cytoplasm mitochondrion	regulation of translational termination nuclear-transcribed mRNA catabolic process, nonsense-mediated decay telomere maintenance translational frameshifting mRNA catabolic process chromatin silencing at silent mating-type cassette	nucleic acid binding RNA-dependent ATPase activity ATP-dependent RNA helicase activity
NOG2	nucleus nucleolus nucleoplasm	ribosomal large subunit export from nucleus ribosome biogenesis ribosome assembly	GTPase activity
NOP1	nuclear outer membrane nucleolus ribosome small nucleolar ribonucleoprotein complex	rRNA modification RNA methylation maturation of SSU-rRNA ribosome biogenesis ribosomal large subunit assembly snoRNA 3'-end processing	methyltransferase activity
NUG1	nucleus nucleolus	ribosome biogenesis rRNA processing	GTPase activity
PAT1	cytoplasmic mRNA processing body	deadenylation-dependent decapping of nuclear-transcribed mRNA chromosome segregation regulation of translational initiation	molecular_function
PRP24	U6 snRNP	spliceosome assembly assembly of spliceosomal tri-snRNP	nucleic acid binding nucleotide binding U6 snRNA binding RNA binding snRNA binding
PRP31	mitochondrion U4/U6 x U5 tri-snRNP complex	nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
PRP38	U4/U6 x U5 tri-snRNP complex	nuclear mRNA splicing, via spliceosome	molecular_function
PRP4	U4/U6 x U5 tri-snRNP complex	nuclear mRNA splicing, via spliceosome	molecular_function
PRP43	mitochondrion spliceosomal complex nuclear outer membrane	maturation of SSU-rRNA ribosomal large subunit biogenesis ribosome biogenesis rRNA processing processing of 27S pre-rRNA	ATP-dependent RNA helicase activity
PRP46	spliceosomal complex	nuclear mRNA splicing, via spliceosome	molecular_function
PRP6	U4/U6 x U5 tri-snRNP complex	nuclear mRNA splicing, via spliceosome	binding molecular_function
SMB1	U4/U6 x U5 tri-snRNP complex U5 snRNP U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
SMD2	U4/U6 x U5 tri-snRNP complex U5 snRNP U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
SNU114	U4/U6 x U5 tri-snRNP complex U5 snRNP	generation of catalytic spliceosome for first transesterification step nuclear mRNA splicing, via spliceosome	GTP binding U5 snRNA binding GTPase activity
SNU23	U4/U6 x U5 tri-snRNP complex	nuclear mRNA splicing, via spliceosome	zinc ion binding metal ion binding molecular_function
SNU66	U4/U6 x U5 tri-snRNP complex	nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
SPP382	nucleus cytoplasm mitochondrion spliceosomal complex	nuclear mRNA splicing, via spliceosome	RNA binding
SQS1	nucleus cytoplasm	biological_process	molecular_function
SRO9	polysome	ribosome biogenesis translation	RNA binding

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
U4/U6 x U5 tri-snRNP complex	1.4795E-29	36	32	16	6292
ribonucleoprotein complex	6.5545E-26	36	514	29	6292
small nuclear ribonucleoprotein complex	7.3052E-26	36	63	17	6292
U6 snRNP	3.5108E-14	36	11	7	6292
nuclear part	8.1685E-12	36	1103	25	6292
macromolecular complex	1.0069E-11	36	1635	29	6292
nucleus	2.8015E-8	36	2041	28	6292
small nucleolar ribonucleoprotein complex	1.2237E-7	36	72	7	6292
nucleolus	1.7231E-7	36	211	10	6292
U5 snRNP	8.6765E-7	36	14	4	6292
cytoplasmic mRNA processing body	1.1783E-6	36	15	4	6292
intracellular organelle part	1.1779E-5	36	2282	26	6292
organelle part	1.1779E-5	36	2282	26	6292
spliceosomal complex	1.1382E-4	36	45	4	6292
nuclear lumen	1.5645E-4	36	453	10	6292
intracellular part	1.583E-4	36	4938	36	6292
intracellular	2.073E-4	36	4975	36	6292
organelle lumen	3.0397E-3	36	660	10	6292
intracellular organelle lumen	3.0397E-3	36	660	10	6292
polysome	3.632E-3	36	16	2	6292
cell part	3.9251E-3	36	5397	36	6292
cell	3.978E-3	36	5399	36	6292
U1 snRNP	4.1015E-3	36	17	2	6292
membrane-enclosed lumen	4.6744E-3	36	700	10	6292
non-membrane-bounded organelle	5.3097E-3	36	959	12	6292
intracellular non-membrane-bounded organelle	5.3097E-3	36	959	12	6292
membrane-bounded organelle	7.1663E-3	36	3771	29	6292
intracellular membrane-bounded organelle	7.1663E-3	36	3771	29	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
mRNA metabolic process	2.3959E-31	36	213	26	6292
nuclear mRNA splicing, via spliceosome	6.8481E-28	36	99	20	6292
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	8.5391E-28	36	100	20	6292
RNA splicing, via transesterification reactions	3.7455E-27	36	107	20	6292
RNA splicing	3.4271E-25	36	132	20	6292
mRNA processing	1.1642E-23	36	156	20	6292
RNA processing	1.762E-21	36	380	24	6292
RNA metabolic process	4.6072E-21	36	954	31	6292
nucleic acid metabolic process	3.1281E-17	36	1415	32	6292
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	7.3595E-16	36	1566	32	6292
gene expression	7.8288E-16	36	1283	30	6292
mRNA catabolic process	1.1333E-15	36	69	12	6292
RNA catabolic process	7.4481E-15	36	80	12	6292
cellular nitrogen compound metabolic process	3.2452E-14	36	1770	32	6292
nitrogen compound metabolic process	4.6651E-14	36	1791	32	6292
cellular macromolecule metabolic process	5.1655E-12	36	2285	33	6292
macromolecule metabolic process	1.2353E-11	36	2349	33	6292
primary metabolic process	8.4319E-9	36	2896	33	6292
cellular macromolecule catabolic process	1.2337E-8	36	265	12	6292
cellular metabolic process	3.478E-8	36	3033	33	6292
macromolecule catabolic process	3.9568E-8	36	294	12	6292
nuclear-transcribed mRNA catabolic process	5.4851E-8	36	38	6	6292
metabolic process	1.1776E-7	36	3157	33	6292
deadenylation-dependent decapping of nuclear-transcribed mRNA	2.8956E-7	36	11	4	6292
cellular catabolic process	1.6939E-6	36	415	12	6292
catabolic process	1.0916E-5	36	496	12	6292
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	1.4427E-5	36	27	4	6292
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	2.7509E-5	36	11	3	6292
ribonucleoprotein complex assembly	1.5789E-4	36	92	5	6292
ribonucleoprotein complex biogenesis	1.8839E-4	36	374	9	6292
cellular process	3.9399E-4	36	4426	34	6292
cellular macromolecular complex subunit organization	3.1575E-3	36	259	6	6292
cellular macromolecular complex assembly	3.4882E-3	36	182	5	6292
regulation of translation	4.0723E-3	36	57	3	6292
spliceosome assembly	4.5976E-3	36	18	2	6292
posttranscriptional regulation of gene expression	4.9312E-3	36	61	3	6292
rRNA processing	5.8164E-3	36	128	4	6292
regulation of cellular protein metabolic process	6.6814E-3	36	68	3	6292
rRNA metabolic process	7.3828E-3	36	137	4	6292
regulation of protein metabolic process	8.4422E-3	36	74	3	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
RNA binding	3.2556E-11	36	367	16	6292
nucleic acid binding	3.2237E-9	36	666	18	6292
binding	1.2535E-7	36	1294	22	6292
snRNA binding	3.1489E-4	36	5	2	6292
RNA helicase activity	1.6944E-3	36	42	3	6292
hydrolase activity, acting on acid anhydrides	3.3473E-3	36	353	7	6292
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	3.3473E-3	36	353	7	6292
pyrophosphatase activity	3.3473E-3	36	353	7	6292
GTPase activity	4.9312E-3	36	61	3	6292
U6 snRNA binding	5.7216E-3	36	1	1	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis