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Protein Overview: CE31156

General Information:
Name(s) found: CE31156 [WormBase]
Description(s) found:
Found 18 descriptions.
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  • WBGene00015650 locus:pkg-2 status:Confirmed UniProt:H2KYN1 protein_id:CCD63995.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 581 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    cAMP-dependent protein kinase complex [IEALink to PubMed article]
    Biological Process: signal transduction [IEALink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    non-membrane spanning protein tyrosine kinase activity [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]
    cAMP-dependent protein kinase regulator activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKSLRYRRDL FRSRTQRYIP KRAFETIGNA LRLNSFLRNL DATQIEKISS AMYPVEVPAG  60
   61 AIIIRQGDLG SIMYVIQEGK VQVVKDNRFV RTMEDGALFG ELAILHHCER TATVRAIESC 120
  121 HLWAIERNVF HAIMMESARE KTMSFKRHLK YSARFGGYPE EVLLRIAEFC TEMRYDAREE 180
  181 LVVKPQYVYL VCRGSVLCDD QGEVSKIVAG QDFELRCGRK GRFERFFVLE GPAHLIKMHV 240
  241 EQLCKALDTT DLDDEIRPRA SSTIEEADVE LEDLQRVSTL GMGGFGRVEL VRSASSRTYA 300
  301 LKIMNKAHIV ETKQESHVVS ERRILMQCDN DYIVRMYKTY RDSEKIYMLM EPCLGGEIWT 360
  361 ILRKKGRFDN DLTRFYCAGA MEALEYLHRK NIVYRDLKPE NMLLDRNGWP KLVDFGFAKK 420
  421 LKNGGRTWTF CGTAEYVAPE IVLNKGHDLS VDIWALGIFM CELLTGSPPF SSTDPMVTYN 480
  481 AILKGLEKWA WPRFVTKEAI DMMLSLCKYE PTERLGFGDI GEIRHHIWFD NFDFVGFRAH 540
  541 RIRPPFIPSV ANDIDTSNFD TFPAFDNFAS GSDESGWDID F

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..158] PSI-BLAST 20.154902 Crystal Structure of Rp-cAMP Binding R1a Subunit of cAMP-dependent Protein Kinase
    2 View Details [159..517] PSI-BLAST 46.39794 Carboxyl-terminal src kinase (csk)
    3 View Details [518..581] PSI-BLAST 87.30103 cAMP-dependent PK, catalytic subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • gated channel activity
    		•  4.08583018944496 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  3.72204192652734 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  3.72204192652734 bayes_pls_golite062009
  • transporter activity
    		•  3.30740141256752 bayes_pls_golite062009
  • cation channel activity
    		•  3.25292809841452 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.24402760485462 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  3.23440982852771 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  3.22710569938713 bayes_pls_golite062009
  • channel activity
    		•  3.22710569938713 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.22443361822344 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.19327339423493 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  3.16687797424765 bayes_pls_golite062009
  • ion channel activity
    		•  3.16567265153907 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.82162580859136 bayes_pls_golite062009
  • cAMP-dependent protein kinase regulator activity
    		•  2.78017841119787 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.74954037604848 bayes_pls_golite062009
  • binding
    		•  2.23085040327125 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.108129577864 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.80472978659874 bayes_pls_golite062009
  • DNA binding
    		•  1.74334792253128 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
    		•  1.68618484766279 bayes_pls_golite062009
  • protein kinase regulator activity
    		•  1.42773903039247 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.40720858109605 bayes_pls_golite062009
  • kinase regulator activity
    		•  1.37734878844137 bayes_pls_golite062009
  • transcription factor activity
    		•  1.37026750024672 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.29733029674587 bayes_pls_golite062009
  • signal transducer activity
    		•  1.29733029674587 bayes_pls_golite062009
  • cyclic nucleotide-gated ion channel activity
    		•  1.26984296847489 bayes_pls_golite062009
  • intracellular cyclic nucleotide activated cation channel activity
    		•  1.26984296847489 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.930640481652164 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.910527807644534 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.848189810874263 bayes_pls_golite062009
  • protein binding
    		•  0.81302068072988 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.784277983338511 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.78164453209132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.274529576258456 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0743937161563444 bayes_pls_golite062009
  • GMP binding
    		•  0.0682628569674704 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0296966221249605 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0295376254112757 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.025744194913981 bayes_pls_golite062009
    2
    Term Confidence Notes
  • cyclic nucleotide-dependent protein kinase activity
    		•  4.97855712164511 bayes_pls_golite062009
  • cAMP-dependent protein kinase activity
    		•  4.66277812893755 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • insulin receptor binding
    		•  3.48393497211158 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.13508395312263 bayes_pls_golite062009
  • signal transducer activity
    		•  3.13508395312263 bayes_pls_golite062009
  • binding
    		•  3.12724619324809 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  2.54265774272269 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  2.16831387024372 bayes_pls_golite062009
  • protein binding
    		•  2.14586566310919 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • actin binding
    		•  1.87817875565699 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.8605803999479 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.85015570449703 bayes_pls_golite062009
  • acetylcholine receptor activator activity
    		•  1.83545227594542 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.82515074380651 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • receptor binding
    		•  1.80554013976158 bayes_pls_golite062009
  • kinase activity
    		•  1.78069536883109 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.686859211081 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.59739467025045 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • DNA binding
    		•  1.52791297022466 bayes_pls_golite062009
  • protein kinase activity
    		•  1.4654611643382 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.32254739984688 bayes_pls_golite062009
  • gamma-tubulin binding
    		•  1.28511591054866 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  1.25765701903393 bayes_pls_golite062009
  • transferase activity
    		•  1.19152443245584 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  1.02996109010965 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.959360414036299 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.950445630788802 bayes_pls_golite062009
  • transcription factor activity
    		•  0.906248759362581 bayes_pls_golite062009
  • growth factor binding
    		•  0.86076618871384 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • actin filament binding
    		•  0.794152600084 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • phosphoinositide 3-kinase regulator activity
    		•  0.688047400629641 bayes_pls_golite062009
  • protein complex binding
    		•  0.65988681496356 bayes_pls_golite062009
  • protein phosphorylated amino acid binding
    		•  0.649814096718101 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.450699332958421 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • phosphotyrosine binding
    		•  0.311079584914389 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  0.29798436765753 bayes_pls_golite062009
  • insulin receptor activity
    		•  0.237134032032089 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.206747304356052 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  0.20643152368029 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  0.20643152368029 bayes_pls_golite062009
  • phosphoprotein binding
    		•  0.16798254471727 bayes_pls_golite062009
  • cytokine receptor binding
    		•  0.16478124520484 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.148194101970458 bayes_pls_golite062009
  • kinase binding
    		•  0.131981353175621 bayes_pls_golite062009
  • peptide binding
    		•  0.118578378753757 bayes_pls_golite062009
  • kinase regulator activity
    		•  0.10704587503284 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.0506751594607393 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.0443241110585009 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle