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Protein Overview: lin-18

General Information:
Name(s) found: lin-18 / CE27692 [WormBase]
Description(s) found:
Found 14 descriptions.
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  • WBGene00003007 locus:lin-18 protein tyrosine kinase status:Confirmed UniProt:Q18041 protein_id:AAA82618.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 562 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEALink to PubMed article]
    Biological Process: polarity specification of anterior/posterior axis [IGILink to PubMed article][IMPLink to PubMed article]
    polarity specification of proximal/distal axis [IGILink to PubMed article][IMPLink to PubMed article]
    establishment of anatomical structure orientation [IGILink to PubMed article][IMPLink to PubMed article]
    hermaphrodite genitalia development [IGILink to PubMed article][IMPLink to PubMed article]
    asymmetric protein localization involved in cell fate determination [IGILink to PubMed article][IMPLink to PubMed article]
    morphogenesis of an epithelium [IGILink to PubMed article][IMPLink to PubMed article]
    signal transduction [IEALink to PubMed article]
    regulation of asymmetric cell division [IGILink to PubMed article][IMPLink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    regulation of vulval development [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    non-membrane spanning protein tyrosine kinase activity [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFISKEEMNR TFGVKAELNY IEMGNVSSYS TKFHYRVMAN IDYLSFTWNA VGIVHYEVYV  60
   61 ESDDSSVLPI VRIPLKGTVP ESLQDFTVEY RCAGHRSGQF AVSLYFTFKY GNKEPLKVKL 120
  121 RQEKICASRD GRRGLNGGYE GHEVDDTDSI DKAFFVIICI AAAFLLIVAA TLICYFKRSK 180
  181 KEDMIPTRLP TSFRNSLKST KSAQPFLLST PRDGPPTLSA ISSAPCSSSS ASGNSIIPSK 240
  241 PRNIDVRRAL LQLYQDRDAF QSLPLDMEGT FGEVRYAIWR QVDDVLNGDV DDEEDTFCNQ 300
  301 EAVYTKTLKN NASPIQLDRF LSDALLFYNI TPHQNLSQVA CVASFGRFDR PETVTDFPLV 360
  361 CYRHQGFGNL KKFLTICRHG DKTKGAQTLR THQLVSLATQ VSSAVAHIHK YRIVHNDIAA 420
  421 RNCLIAEVNG RLQVQLCDSA LSRDLFPADY HCLGDNENRP LKWMSPEAIA NELYSSAADV 480
  481 WSLGVLLWEL MSLGGSPHAE IDPEEVYTMI LKGKRLQQPN NCPDQLYEVM LCCWRVLSED 540
  541 RPSSEQVVHG LRDFNIQLSQ YI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..79] PSI-BLAST 17.69897 Solution structure of the second fn3 domain of Eph receptor A8 protein
    2 View Details [80..562] PSI-BLAST 77.0 CHICKEN SRC TYROSINE KINASE

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • PTB domain binding
    		•  7.59954514905135 bayes_pls_golite062009
  • cytokine receptor activity
    		•  6.1064338595335 bayes_pls_golite062009
  • insulin receptor activity
    		•  5.32497038633998 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor activity
    		•  5.11860004897785 bayes_pls_golite062009
  • interleukin-6 binding
    		•  4.92289154730411 bayes_pls_golite062009
  • interleukin-6 receptor activity
    		•  4.92289154730411 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  4.81256300373074 bayes_pls_golite062009
  • receptor activity
    		•  4.66147271961356 bayes_pls_golite062009
  • cytokine binding
    		•  4.43581512268554 bayes_pls_golite062009
  • growth factor binding
    		•  4.06808996928726 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.69234048247377 bayes_pls_golite062009
  • signal transducer activity
    		•  3.69234048247377 bayes_pls_golite062009
  • protein binding
    		•  3.24522318184038 bayes_pls_golite062009
  • oncostatin-M receptor activity
    		•  3.21526092940028 bayes_pls_golite062009
  • leukemia inhibitory factor receptor activity
    		•  3.21526092940028 bayes_pls_golite062009
  • binding
    		•  3.12471204223368 bayes_pls_golite062009
  • SH2 domain binding
    		•  3.02533711127154 bayes_pls_golite062009
  • peptide hormone binding
    		•  3.00179150648816 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor binding
    		•  2.93858020991812 bayes_pls_golite062009
  • ciliary neurotrophic factor binding
    		•  2.91569341552992 bayes_pls_golite062009
  • cytokine receptor binding
    		•  2.64284554734326 bayes_pls_golite062009
  • interleukin-11 receptor activity
    		•  2.34894404420874 bayes_pls_golite062009
  • interleukin-11 binding
    		•  2.34894404420874 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.25224014924603 bayes_pls_golite062009
  • growth hormone receptor activity
    		•  2.20449493522 bayes_pls_golite062009
  • prolactin receptor activity
    		•  2.15346920063421 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.13821456373219 bayes_pls_golite062009
  • peptide binding
    		•  2.04467673245315 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  2.01367445237355 bayes_pls_golite062009
  • DNA binding
    		•  1.95396591505956 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.91712452737778 bayes_pls_golite062009
  • transcription activator activity
    		•  1.72598380808039 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.69642470905172 bayes_pls_golite062009
  • interleukin-2 binding
    		•  1.67132604890013 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  1.6158868405814 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.61421027298524 bayes_pls_golite062009
  • kinase activity
    		•  1.57994485110649 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.44501485815273 bayes_pls_golite062009
  • protein kinase activity
    		•  1.42856560840953 bayes_pls_golite062009
  • insulin binding
    		•  1.40490582483684 bayes_pls_golite062009
  • heparin binding
    		•  1.40418056272895 bayes_pls_golite062009
  • receptor binding
    		•  1.31676259534833 bayes_pls_golite062009
  • hormone binding
    		•  1.31120662451488 bayes_pls_golite062009
  • transcription factor activity
    		•  1.20939978283833 bayes_pls_golite062009
  • transferase activity
    		•  1.13635878582843 bayes_pls_golite062009
  • cell surface binding
    		•  1.05599555585797 bayes_pls_golite062009
  • mercury ion binding
    		•  1.02618624913674 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.86564366658585 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.703490254739121 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.68515307569834 bayes_pls_golite062009
  • kinase binding
    		•  0.65927255037265 bayes_pls_golite062009
  • enzyme binding
    		•  0.60195860585095 bayes_pls_golite062009
  • identical protein binding
    		•  0.564711394496051 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.554350228628563 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.46168925186147 bayes_pls_golite062009
  • transcription factor binding
    		•  0.428445565158989 bayes_pls_golite062009
  • protein kinase binding
    		•  0.405060010394646 bayes_pls_golite062009
  • cytokine activity
    		•  0.30745438910441 bayes_pls_golite062009
  • peptidase activator activity
    		•  0.249363133780499 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.211855991357483 bayes_pls_golite062009
  • structural molecule activity
    		•  0.18965275490219 bayes_pls_golite062009
  • pattern binding
    		•  0.16768253393396 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.1430595594485 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.116391819218123 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.116377273702831 bayes_pls_golite062009
  • interleukin-2 receptor activity
    		•  0.115337814289139 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.05634414824449 bayes_pls_golite062009
  • growth factor activity
    		•  0.0477008672713168 bayes_pls_golite062009
    2
    Term Confidence Notes
  • PTB domain binding
    		•  8.10304453468842 bayes_pls_golite062009
  • insulin receptor activity
    		•  6.0833679870912 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  4.09909681656699 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  3.43994026029707 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  3.41480681854114 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • insulin-like growth factor I binding
    		•  3.39379474022325 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  3.26784640416242 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.1965684217331 bayes_pls_golite062009
  • SH2 domain binding
    		•  3.03401803018883 bayes_pls_golite062009
  • receptor activity
    		•  2.96273889901429 bayes_pls_golite062009
  • signal transducer activity
    		•  2.85730457922199 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.85730457922199 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • insulin-like growth factor II binding
    		•  2.74473718307416 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  2.70917101514973 bayes_pls_golite062009
  • growth factor binding
    		•  2.61235080252818 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  2.1677218320705 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  2.1677218320705 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • insulin binding
    		•  2.0719180171079 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  1.9011085456623 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.46547714006072 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  1.42275431028856 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  1.25765701903393 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  1.24312972088703 bayes_pls_golite062009
  • activin binding
    		•  1.22461306010416 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • phosphoinositide 3-kinase regulator activity
    		•  1.03150090191995 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.00304216158732 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • cytokine receptor binding
    		•  0.966158970381052 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.880236579821909 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.872782211382796 bayes_pls_golite062009
  • transcription activator activity
    		•  0.846644791435606 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • activin receptor activity
    		•  0.811117252475389 bayes_pls_golite062009
  • amine binding
    		•  0.783881819862438 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • Janus kinase activity
    		•  0.580310109637219 bayes_pls_golite062009
  • peptide binding
    		•  0.560033905645957 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  0.547121592096699 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.450699332958421 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • 3-phosphoinositide-dependent protein kinase binding
    		•  0.372842462336059 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • peptide hormone binding
    		•  0.312169974523858 bayes_pls_golite062009
  • phosphotyrosine binding
    		•  0.311079584914389 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  0.294256794094724 bayes_pls_golite062009
  • transforming growth factor beta binding
    		•  0.287757704969289 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.266450215230107 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.229808864843639 bayes_pls_golite062009
  • cytokine binding
    		•  0.17817111033393 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.148194101970458 bayes_pls_golite062009
  • activin receptor activity, type I
    		•  0.117759584117941 bayes_pls_golite062009
  • nitric-oxide synthase regulator activity
    		•  0.00407218246327123 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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