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Protein Overview: rab-7

General Information:
Name(s) found: rab-7 / CE03777 [WormBase]
Description(s) found:
Found 18 descriptions.
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  • WBGene00004271 locus:rab-7 status:Confirmed UniProt:Q23146 protein_id:CAA91357.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 209 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEALink to PubMed article]
    Biological Process: signal transduction [IEALink to PubMed article]
    small GTPase mediated signal transduction [IEALink to PubMed article]
    locomotion [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    post-embryonic body morphogenesis [IMPLink to PubMed article]
    protein transport [IEALink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    endocytosis [IMPLink to PubMed article]
    intracellular protein transport [IEALink to PubMed article]
    positive regulation of multicellular organism growth [IMPLink to PubMed articleLink to PubMed article]
    nucleocytoplasmic transport [IEALink to PubMed article]
    oocyte growth [IMPLink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    cell death [IMPLink to PubMed article]
    Molecular Function: GTP binding [IEALink to PubMed article][ISSLink to PubMed article]
    ATP binding [IEALink to PubMed article]
    protein binding [IEALink to PubMed article]
    GTPase activity [IEALink to PubMed article][ISSLink to PubMed article]
    transcription factor binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGTRKKALL KVIILGDSGV GKTSLMNQYV NRRFSNQYKA TIGADFLTRD VNIDDRTVTL  60
   61 QIWDTAGQER FQSLGVAFYR GADCCVLAFD VTNAASFKSL DSWRDEFLIQ ASPRDPDHFP 120
  121 FVLLGNKVDL ESQRAVSSKR AQSWCQTKGN IPYYEVSAKE ALNVEAAFLA IARDALARES 180
  181 QETNDFPEFP DQIRLNPNQQ NQQNSGCNC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..209] PSI-BLAST 53.0 The crystal structures of the REP-1 protein in complex with monoprenylated Rab7 protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • actin binding
    		•  2.84620358490972 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.74389108884083 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.67097555143215 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.66896300219871 bayes_pls_golite062009
  • hydrolase activity
    		•  2.65461298232951 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.65161658635465 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.64849912301318 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  2.50494515048649 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  2.39629638016861 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  2.39600931083427 bayes_pls_golite062009
  • microfilament motor activity
    		•  2.37164398259429 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  2.36051733655256 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  2.35906629925754 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  2.35679406876731 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  2.29486577878686 bayes_pls_golite062009
  • ATPase activity
    		•  2.2625504298178 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.24901251684901 bayes_pls_golite062009
  • actin filament binding
    		•  2.1683792904715 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  1.89320355239381 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  1.88721318481223 bayes_pls_golite062009
  • GTP binding
    		•  1.87900088157196 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  1.77111739879769 bayes_pls_golite062009
  • carboxylic acid transmembrane transporter activity
    		•  1.75695995185278 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.65609907941094 bayes_pls_golite062009
  • GTPase activity
    		•  1.6309422514633 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.49633029954726 bayes_pls_golite062009
  • motor activity
    		•  1.49368359124081 bayes_pls_golite062009
  • DNA binding
    		•  1.48341220422804 bayes_pls_golite062009
  • microtubule motor activity
    		•  1.47358567315228 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.3182108176243 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.30136714640988 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • ATP binding
    		•  0.98146619596929 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.949788783884952 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.931486373329219 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  0.876296121718575 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.704934361725919 bayes_pls_golite062009
  • kinase activity
    		•  0.691112783105676 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.683309012097319 bayes_pls_golite062009
  • signal transducer activity
    		•  0.683309012097319 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  0.63002958837536 bayes_pls_golite062009
  • amino acid transmembrane transporter activity
    		•  0.585668369219566 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.499834566483656 bayes_pls_golite062009
  • drug transmembrane transporter activity
    		•  0.38711726712063 bayes_pls_golite062009
  • transcription activator activity
    		•  0.374651542607188 bayes_pls_golite062009
  • transcription factor activity
    		•  0.341088753451767 bayes_pls_golite062009
  • signal recognition particle binding
    		•  0.29390189699022 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.282397764628576 bayes_pls_golite062009
  • protein transporter activity
    		•  0.217249710833262 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.106147926780353 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.0430764033739892 bayes_pls_golite062009
  • protein kinase activity
    		•  0.0364322017534667 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.78

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle