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Protein Overview: frk-1

General Information:
Name(s) found: frk-1 / CE03609 [WormBase]
Description(s) found:
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  • WBGene00001487 locus:frk-1 status:Confirmed UniProt:Q22146 protein_id:CAA92609.1 [WormBase]
  • pir||T24437 hypothetical protein T04B2.2 - Caenorhabditis elegans [NCBI NR]
  • gi|3879411|emb|CAA92609.1| C. elegans protein T04B2.2, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|17540892|ref|NP_501818.1| Fer oncogene Related Kinase family member (frk-1) [Caenorhabditis elegans] [NCBI NR]
  • Fer-related kinase 1 OS=Caenorhabditis elegans GN=frk-1 PE=1 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE03609 WBGene00001487 locus:frk-1 Src homology domain 2, tyrosine-protein kinase (FES\/FPS subfamily) status:Confirmed TR:Q22146 protein_id:CAA92609.1 [wormpep150.fasta]
  • 03609 WBGene00001487 locus:frk-1 Src homology domain 2, tyrosine-protein kinase (FES\/FPS subfamily) status:Confirmed TR:Q22146 protein_id:CAA92609.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • fer oncogene Related Kinase (44.6 kD) (frk-1) [Caenorhabditis elegans]gi|3879411|emb|CAA92609.1| Hypothetical protein T04B2.2 [Caenorhabditis elegans]gi|7507062|pir||T24437 hypothetical protein T04B2.2 - Caenorhabditis elegans [nrdb_11152004_Chlamydomonas]
  • locus:frk-1 Src homology domain 2, tyrosine-protein kinase (FES\/FPS subfamily) status:Confirmed TR:Q22146 protein_id:CAA92609.1 [wormpep115.fasta.reversed]
  • CE03609 locus:frk-1 Src homology domain 2, tyrosine-protein kinase (FES\/FPS subfamily) status:Predicted TR:Q22146 protein_id:CAA92609.1 [wormpep80.hongbin]
  • CE03609 WBGene00001487 locus:frk-1 Src homology domain 2, tyrosine-protein kinase (FES\/FPS subfamily) status:Confirmed UniProt:Q22146_CAEEL protein_id:CAA92609.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE03609 WBGene00001487 locus:frk-1 Src homology domain 2, tyrosine-protein kinase (FES\/FPS subfamily) status:Confirmed UniProt:Q22146_CAEEL protein_id:CAA92609.1| [wormORF-contam.fasta]
  • Hypothetical protein T04B2.2 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Fer oncogene Related Kinase family member (frk-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE03609 WBGene00001487 locus:frk-1 Src homology domain 2, tyrosine-protein kinase (FES\/FPS subfamily) status:Confirmed UniProt:Q22146 protein_id:CAA92609.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE03609 WBGene00001487 locus:frk-1 status:Confirmed UniProt:Q22146 protein_id:CAA92609.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE03609 WBGene00001487 locus:frk-1 status:Confirmed UniProt:Q22146 protein_id:CAA92609.1 Non-specific protein-tyrosine kinase [c_elegans-PRJNA13758-WS250-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 390 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cell-cell junction [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article][IEALink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    Biological Process: cell-cell adhesion [IMPLink to PubMed article]
    regulation of protein localization [IMPLink to PubMed article]
    signal transduction [IEALink to PubMed article]
    embryonic body morphogenesis [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    positive regulation of cell proliferation [IMPLink to PubMed article]
    protein amino acid autophosphorylation [IDALink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    regulation of epidermal cell differentiation [IMPLink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    non-membrane spanning protein tyrosine kinase activity [IEALink to PubMed article]
    protein kinase activity [IDALink to PubMed article][IEALink to PubMed article]
    beta-catenin binding [IPILink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGTVEKSSNN DASVTDDIRS AEYYHGMVPR QDAEGFLKRE GDFLVRKTEQ MPGKVVLAMS  60
   61 VRVTDELCRH FMLNMDPTSN KFYFEHTHQE STISELINWH MTTKTPISAA SGAKIRRPME 120
  121 RSPWLINHDS IVANKKLGEG AFGDVFIAEL DQGGKQEVAV KTMRAEATRE ARLRFMKEAR 180
  181 LMRKYQHKHV VKLIGVAIHE HPLMIVMEYC PNGSLLSHLK KNKVSLIEKL RFTTEAADGI 240
  241 AYLERSKCIH RDIAARNCLL SAKNELKISD FGMSDNKDEI KDETLEKVPI KWLAPETMQE 300
  301 KVYTHKTDIW TFGVLVWEIY SDGAEPYPGL TKIQTRAKIV VNDYRMKMPD GTHPTVADVV 360
  361 TGTCWQKNPE KRSTMDSIHK KLREFYESKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..390] PSI-BLAST 101.0 No description for 2h8hA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  3.43994026029707 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  3.41480681854114 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • CD8 receptor binding
    		•  3.34636716492159 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  2.9751846707539 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.52531786618214 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.46424348876434 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • signal transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.37122853419919 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • SH2 domain binding
    		•  2.08937039830657 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.9016235206634 bayes_pls_golite062009
  • actin binding
    		•  1.87817875565699 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine kinase activity
    		•  1.66669268613198 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • PTB domain binding
    		•  1.56656184134104 bayes_pls_golite062009
  • growth factor binding
    		•  1.53863828216563 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  1.42275431028856 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • tubulin binding
    		•  1.13686658158825 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  1.10045286406485 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  1.10045286406485 bayes_pls_golite062009
  • cation channel activity
    		•  1.04999722123563 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  0.98689034826741 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • actin filament binding
    		•  0.794152600084 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.75189004129952 bayes_pls_golite062009
  • microtubule binding
    		•  0.734274677384472 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • JUN kinase kinase kinase kinase activity
    		•  0.546647574638943 bayes_pls_golite062009
  • insulin binding
    		•  0.546269851452869 bayes_pls_golite062009
  • activin binding
    		•  0.510364757301021 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • 3-phosphoinositide-dependent protein kinase binding
    		•  0.372842462336059 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • phosphotyrosine binding
    		•  0.311079584914389 bayes_pls_golite062009
  • channel activity
    		•  0.287189255116606 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.287189255116606 bayes_pls_golite062009
  • kinase binding
    		•  0.26752427107238 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.261869836686301 bayes_pls_golite062009
  • ion channel activity
    		•  0.241519346930618 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • insulin receptor activity
    		•  0.188254408239569 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.150740450460731 bayes_pls_golite062009
  • JUN kinase kinase kinase activity
    		•  0.0613131034808199 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.0506751594607393 bayes_pls_golite062009
  • cation binding
    		•  0.046173055856133 bayes_pls_golite062009
  • metal ion binding
    		•  0.046173055856133 bayes_pls_golite062009
  • ion binding
    		•  0.0389662058697694 bayes_pls_golite062009
  • protein kinase binding
    		•  0.00674998152095019 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle