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Protein Overview: rok-PA

General Information:
Name(s) found: rok-PA / FBpp0074061 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Rho-kinase is referred to in FlyBase by the symbol Dmel\rok (CG9774, FBgn0026181). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16519142..16531452. It has the cytological map location 14F2-14F4. There is experimental evidence that it has the molecular function</span>: GTPase binding; protein binding; protein serine/threonine kinase activity. There is experimental evidence for 22 unique biological process</span> terms, many of which group under: anatomical structure development; reproductive process in a multicellular organism; cell cycle; ovarian nurse cell to oocyte transport; cell cycle process; regulation of cellular component organization; organ morphogenesis; regulation of developmental process; actin filament-based process; organelle organization. 14 alleles are reported. The phenotypes of these alleles are annotated with: epithelial cell; dorsal hair; mushroom body vertical lobe; nucleus; larval epidermis; embryonic leading edge cell. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1390 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: dorsal closure [TAS]
    regulation of cell shape [IMP]
    regulation of actin filament bundle assembly [IGI][IMP]
    epidermis development [IMP]
    cytokinesis [IMP]
    protein amino acid phosphorylation [ISS][NAS]
    mitotic spindle elongation [IMP]
    oocyte axis specification [IMP]
    regulation of axonogenesis [IGI]
    imaginal disc-derived wing hair organization [IGI][IMP]
    morphogenesis of embryonic epithelium [IMP]
    ommatidial rotation [NAS]
    ovarian nurse cell to oocyte transport [IMP]
    female germline ring canal stabilization [IMP]
    establishment of ommatidial planar polarity [IMP]
    mitosis [IMP]
    Rho protein signal transduction [IPI]
    nurse cell nucleus anchoring [IMP]
    establishment of protein localization [IMP]
    regulation of actin cytoskeleton organization [IMP]
    oocyte development [IMP]
    regulation of protein amino acid phosphorylation [IMP]
    establishment of planar polarity [TAS]
    establishment of imaginal disc-derived wing hair orientation [IMP]
    mitotic anaphase B [IMP]
    actin cytoskeleton organization [IMP]
    Molecular Function: ATP binding [IEA]
    protein binding [IPI]
    GTPase binding [IPI]
    diacylglycerol binding [ISS]
    protein serine/threonine kinase activity [IDA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPAGRETVTK QRSMDVERRR RANTLEREMR DPTSICNVDC LLDTVSALVS DCDHESLRRL  60
   61 KNIEQYAAKY KPLAMQINQL RMNVEDFHFI KLIGAGAFGE VQLVRHKSSS QVYAMKRLSK 120
  121 FEMMKRPDSA FFWEERHIMA HANSEWIVQL HFAFQDAKYL YMVMDFMPGG DIVSLMGDYD 180
  181 IPEKWAIFYT MEVVLALDTI HNMGFVHRDV KPDNMLLDSY GHLKLADFGT CMRMGANGQV 240
  241 VSSNAVGTPD YISPEVLQSQ GVDNEYGREC DWWSVGIFLY EMLFGETPFY ADSLVGTYGK 300
  301 IMDHKNSLSF PPEVEISEQA KALIRAFLTD RTQRLGRYGI EDIKAHPFFR NDTWSFDNIR 360
  361 ESVPPVVPEL SSDDDTRNFE DIERDEKPEE VFPVPKGFDG NHLPFIGFTY TGDYQLLSSD 420
  421 TVDAESKEAN VANSGAASNN HGHGHNHRHR PSNSNELKRL EALLERERGR SEALEQQDAG 480
  481 LRQQIELITK REAELQRIAS EYEKDLALRQ HNYKVAMQKV EQEIELRKKT EALLVETQRN 540
  541 LENEQKTRAR DLNINDKVVS LEKQLLEMEQ SYKTETENTQ KLKKHNAELD FTVKSQEEKV 600
  601 RDMVDMIDTL QKHKEELGQE NAELQALVVQ EKNLRSQLKE MHKEAENKMQ TLINDIERTM 660
  661 CREQKAQEDN RALLEKISDL EKAHAGLDFE LKAAQGRYQQ EVKAHQETEK SRLVSREEAN 720
  721 LQEVKALQSK LNEEKSARIK ADQHSQEKER QLSMLSVDYR QIQLRLQKLE GECRQESEKV 780
  781 AALQSQLDQE HSKRNALLSE LSLHSSEVAH LRSRENQLQK ELSTQREAKR RFEEDLTQLK 840
  841 STHHEALANN RELQAQLEAE QCFSRLYKTQ ANENREESAE RLSKIEDLEE ERVSLKHQVQ 900
  901 VAVARADSEA LARSIAEETV ADLEKEKTIK ELELKDFVMK HRNEINAKEA ALATLKEAEN 960
  961 ELHKKLGQKA AEYEDLVQQH KKQQEELALM RSSKDEEITK LLDKCKNEVL LKQVAVNKLA1020
 1021 EVMNRRDSDL PKQKNKARST AELRKKEKEM RRLQQELSQE RDKFNQLLLK HQDLQQLCAE1080
 1081 EQQLKQKMVM EIDCKATEIE NLQSKLNETA SLSSADNDPE DSQHSSLLSL TQDSVFEGWL1140
 1141 SVPNKQNRRR GHGWKRQYVI VSSRKIIFYN SDIDKHNTTD AVLILDLSKV YHVRSVTQGD1200
 1201 VIRADAKEIP RIFQLLYAGE GASHRPDEQS QLDVSVLHGN CNEERPGTIV HKGHEFVHIT1260
 1261 YHMPTACEVC PKPLWHMFKP PAAYECKRCR NKIHKEHVDK HDPLAPCKLN HDPRSARDML1320
 1321 LLAATPEDQS LWVARLLKRI QKSGYKAASY NNNSTDGSKI SPSQSTRSSY KPYAVNVQRS1380
 1381 ATLPANSSLK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..82] PSI-BLAST 94.69897 Crystal Structure of ROCK 1 bound to fasudil
    2 View Details [83..548] PSI-BLAST 44.30103 G-protein coupled receptor kinase 2, N-terminal domain; G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1); G-protein coupled receptor kinase 2
    3 View Details [549..750] FFAS03 2.17 Ribonuclease domain of colicin E3; Colicin E3 translocation domain; Colicin E3 receptor domain
    4 View Details [751..1071] PSI-BLAST 19.154902 Heavy meromyosin subfragment
    5 View Details [1072..1107] PSI-BLAST 5.69897 No description for 2i1jA was found.
    6 View Details [1108..1253] FFAS03 2.06 Solution structure of the PH domain of protein kinase C, D2 type from human
    7 View Details [1254..1314] PSI-BLAST 13.39794 NMR STRUCTURE OF A PROTEIN KINASE C-G PHORBOL-BINDING DOMAIN, MINIMIZED AVERAGE STRUCTURE
    8 View Details [1315..1390] PSI-BLAST 13.39794 No description for 2uzpA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • cyclic nucleotide-dependent protein kinase activity
    		•  4.97855712164511 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cAMP-dependent protein kinase activity
    		•  4.66277812893755 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  2.54265774272269 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • signal transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  2.16831387024372 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • actin binding
    		•  1.87817875565699 bayes_pls_golite062009
  • acetylcholine receptor activator activity
    		•  1.83545227594542 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.82515074380651 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.6084489855403 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • gamma-tubulin binding
    		•  1.28511591054866 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  1.25765701903393 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.16049201286103 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • Ran GTPase binding
    		•  1.07023555877478 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  1.02996109010965 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.965872107791437 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.959360414036299 bayes_pls_golite062009
  • growth factor binding
    		•  0.86076618871384 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • actin filament binding
    		•  0.794152600084 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.450699332958421 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase signaling protein activity
    		•  0.28468123649303 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.266450215230107 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • insulin receptor activity
    		•  0.237134032032089 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.226760162354251 bayes_pls_golite062009
  • profilin binding
    		•  0.21255426011209 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  0.20643152368029 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  0.20643152368029 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.148194101970458 bayes_pls_golite062009
  • peptide binding
    		•  0.118578378753757 bayes_pls_golite062009
  • alpha-catenin binding
    		•  0.102004310679969 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.0506751594607393 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • actin binding
    		•  3.56545913943715 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.36168834560682 bayes_pls_golite062009
  • binding
    		•  3.16245771986829 bayes_pls_golite062009
  • protein binding
    		•  3.00808514157552 bayes_pls_golite062009
  • insulin receptor binding
    		•  2.60167278410043 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.13588211069605 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.06185019777926 bayes_pls_golite062009
  • actin filament binding
    		•  1.91515281241149 bayes_pls_golite062009
  • DNA binding
    		•  1.80618207914839 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  1.63593384010249 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.59061714977326 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.55414958698765 bayes_pls_golite062009
  • kinase activity
    		•  1.52393509273639 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.51882027675546 bayes_pls_golite062009
  • signal transducer activity
    		•  1.51882027675546 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.50594272418871 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.48917924547615 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.39413069155432 bayes_pls_golite062009
  • protein kinase activity
    		•  1.36096357986245 bayes_pls_golite062009
  • transporter activity
    		•  1.29925758003665 bayes_pls_golite062009
  • receptor activity
    		•  1.18359632789069 bayes_pls_golite062009
  • Rho guanyl-nucleotide exchange factor activity
    		•  1.15172245597736 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.13267118951633 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.12262165497943 bayes_pls_golite062009
  • SH2 domain binding
    		•  1.11962718814384 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.10613306581585 bayes_pls_golite062009
  • transferase activity
    		•  1.09391396934652 bayes_pls_golite062009
  • enzyme binding
    		•  0.986198119454688 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.975799143332123 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.902696448574164 bayes_pls_golite062009
  • receptor binding
    		•  0.898748069011275 bayes_pls_golite062009
  • phospholipid binding
    		•  0.864843473490307 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.830314446783898 bayes_pls_golite062009
  • kinase binding
    		•  0.829679711601002 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.807688160227952 bayes_pls_golite062009
  • Ran GTPase binding
    		•  0.709291241748316 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.650240628628722 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.62326150960884 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.578612934164552 bayes_pls_golite062009
  • small GTPase binding
    		•  0.56438433639766 bayes_pls_golite062009
  • protein kinase binding
    		•  0.557283580441975 bayes_pls_golite062009
  • GTPase binding
    		•  0.550421293582715 bayes_pls_golite062009
  • phosphoinositide binding
    		•  0.45899353522401 bayes_pls_golite062009
  • protein complex binding
    		•  0.424439033593144 bayes_pls_golite062009
  • structural molecule activity
    		•  0.332112521019418 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.328898130778985 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  0.0941284428910731 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0707105517897648 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0620154731603239 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0594013389870999 bayes_pls_golite062009
    7
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  4.00373045859121 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.86705824967236 bayes_pls_golite062009
  • binding
    		•  2.79128751898373 bayes_pls_golite062009
  • GTPase regulator activity
    		•  2.70614727793157 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  2.68579854252375 bayes_pls_golite062009
  • protein binding
    		•  2.34145982999922 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.10625597744594 bayes_pls_golite062009
  • DNA binding
    		•  2.06132216820898 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  2.06038764955701 bayes_pls_golite062009
  • kinase activity
    		•  2.03632850156074 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.9750017471254 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.95738547986197 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.91441035614579 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.8531437045627 bayes_pls_golite062009
  • protein kinase activity
    		•  1.62921423829738 bayes_pls_golite062009
  • transferase activity
    		•  1.4550521488922 bayes_pls_golite062009
  • transcription factor activity
    		•  1.39657429296564 bayes_pls_golite062009
  • signal transducer activity
    		•  1.25507073225414 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.25507073225414 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.10685156896266 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  1.09070479183477 bayes_pls_golite062009
  • Ras guanyl-nucleotide exchange factor activity
    		•  0.958295643211986 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.956859696337723 bayes_pls_golite062009
  • GTPase activator activity
    		•  0.717730683557543 bayes_pls_golite062009
  • kinase binding
    		•  0.494958567742569 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.298334474872045 bayes_pls_golite062009
  • catalytic activity
    		•  0.194464246602439 bayes_pls_golite062009
    8 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle