YRC Public Data Repository - Protein Structure Prediction

Protein:	rok-PA
Organism:	Drosophila melanogaster
Length:	1390 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for rok-PA.

Description	E-value	Query Range	Subject Range
gi\|50737091 - gi\|50737091\|ref\|XP_419151.1\| PREDICTED: similar to corneal epithelial Rho-associated-ser/thr kinase;...	571.0	[0..10]	[1371..609]

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Predicted Domain #1

Region A:
Residues: [1-82]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPAGRETVTK QRSMDVERRR RANTLEREMR DPTSICNVDC LLDTVSALVS DCDHESLRRL  60
   61 KNIEQYAAKY KPLAMQINQL RM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	94.69897
Match:	2esmA
Description:	Crystal Structure of ROCK 1 bound to fasudil
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [83-548]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVEDFHFIKL IGAGAFGEVQ LVRHKSSSQV YAMKRLSKFE MMKRPDSAFF WEERHIMAHA  60
   61 NSEWIVQLHF AFQDAKYLYM VMDFMPGGDI VSLMGDYDIP EKWAIFYTME VVLALDTIHN 120
  121 MGFVHRDVKP DNMLLDSYGH LKLADFGTCM RMGANGQVVS SNAVGTPDYI SPEVLQSQGV 180
  181 DNEYGRECDW WSVGIFLYEM LFGETPFYAD SLVGTYGKIM DHKNSLSFPP EVEISEQAKA 240
  241 LIRAFLTDRT QRLGRYGIED IKAHPFFRND TWSFDNIRES VPPVVPELSS DDDTRNFEDI 300
  301 ERDEKPEEVF PVPKGFDGNH LPFIGFTYTG DYQLLSSDTV DAESKEANVA NSGAASNNHG 360
  361 HGHNHRHRPS NSNELKRLEA LLERERGRSE ALEQQDAGLR QQIELITKRE AELQRIASEY 420
  421 EKDLALRQHN YKVAMQKVEQ EIELRKKTEA LLVETQRNLE NEQKTR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	44.30103
Match:	1omwA
Description:	G-protein coupled receptor kinase 2, N-terminal domain; G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1); G-protein coupled receptor kinase 2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
cyclic nucleotide-dependent protein kinase activity	4.97855712164511	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
cAMP-dependent protein kinase activity	4.66277812893755	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
transferase activity	3.97138602499442	bayes_pls_golite062009
protein tyrosine kinase activity	2.8153155526437	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
transmembrane receptor activity	2.59526003830791	bayes_pls_golite062009
transmembrane receptor protein kinase activity	2.54265774272269	bayes_pls_golite062009
molecular transducer activity	2.40586892801446	bayes_pls_golite062009
signal transducer activity	2.40586892801446	bayes_pls_golite062009
receptor activity	2.39311927684508	bayes_pls_golite062009
protein binding	2.276111749106	bayes_pls_golite062009
tubulin binding	2.18641675163967	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	2.16831387024372	bayes_pls_golite062009
cytoskeletal protein binding	2.12615078788254	bayes_pls_golite062009
receptor signaling protein activity	2.10379226653669	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
microtubule binding	1.88110801192607	bayes_pls_golite062009
actin binding	1.87817875565699	bayes_pls_golite062009
acetylcholine receptor activator activity	1.83545227594542	bayes_pls_golite062009
phosphoinositide 3-kinase binding	1.82515074380651	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.81249386965144	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
insulin receptor substrate binding	1.62657794525303	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	1.6084489855403	bayes_pls_golite062009
transcription regulator activity	1.56748951434625	bayes_pls_golite062009
DNA binding	1.35333135345112	bayes_pls_golite062009
gamma-tubulin binding	1.28511591054866	bayes_pls_golite062009
kinase binding	1.26086833316556	bayes_pls_golite062009
ErbB-3 class receptor binding	1.25765701903393	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
nucleic acid binding	1.16049201286103	bayes_pls_golite062009
transporter activity	1.11833481501707	bayes_pls_golite062009
transcription factor activity	1.10928254946881	bayes_pls_golite062009
Ran GTPase binding	1.07023555877478	bayes_pls_golite062009
protein kinase binding	1.06030596516506	bayes_pls_golite062009
ErbB-2 class receptor binding	1.02996109010965	bayes_pls_golite062009
transmembrane transporter activity	0.97575992765505	bayes_pls_golite062009
oxidoreductase activity	0.965872107791437	bayes_pls_golite062009
cyclin-dependent protein kinase activity	0.959360414036299	bayes_pls_golite062009
growth factor binding	0.86076618871384	bayes_pls_golite062009
MAP kinase activity	0.81943579965027	bayes_pls_golite062009
actin filament binding	0.794152600084	bayes_pls_golite062009
substrate-specific transporter activity	0.705905455086486	bayes_pls_golite062009
structural constituent of cytoskeleton	0.612883428421652	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
enzyme binding	0.46284745266176	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.450699332958421	bayes_pls_golite062009
protein kinase C activity	0.41587987561486	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
MAP kinase kinase activity	0.35402045013148	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase signaling protein activity	0.28468123649303	bayes_pls_golite062009
insulin receptor binding	0.266450215230107	bayes_pls_golite062009
protein complex binding	0.239339759110451	bayes_pls_golite062009
insulin receptor activity	0.237134032032089	bayes_pls_golite062009
SH2 domain binding	0.226760162354251	bayes_pls_golite062009
profilin binding	0.21255426011209	bayes_pls_golite062009
transforming growth factor beta receptor activity	0.20643152368029	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity	0.20643152368029	bayes_pls_golite062009
ion transmembrane transporter activity	0.148194101970458	bayes_pls_golite062009
peptide binding	0.118578378753757	bayes_pls_golite062009
alpha-catenin binding	0.102004310679969	bayes_pls_golite062009
transforming growth factor beta receptor activity, type I	0.0506751594607393	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.0040394359628233	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [549-750]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ARDLNINDKV VSLEKQLLEM EQSYKTETEN TQKLKKHNAE LDFTVKSQEE KVRDMVDMID  60
   61 TLQKHKEELG QENAELQALV VQEKNLRSQL KEMHKEAENK MQTLINDIER TMCREQKAQE 120
  121 DNRALLEKIS DLEKAHAGLD FELKAAQGRY QQEVKAHQET EKSRLVSREE ANLQEVKALQ 180
  181 SKLNEEKSAR IKADQHSQEK ER

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.17
Match:	1jchA
Description:	Ribonuclease domain of colicin E3; Colicin E3 translocation domain; Colicin E3 receptor domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [751-1071]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLSMLSVDYR QIQLRLQKLE GECRQESEKV AALQSQLDQE HSKRNALLSE LSLHSSEVAH  60
   61 LRSRENQLQK ELSTQREAKR RFEEDLTQLK STHHEALANN RELQAQLEAE QCFSRLYKTQ 120
  121 ANENREESAE RLSKIEDLEE ERVSLKHQVQ VAVARADSEA LARSIAEETV ADLEKEKTIK 180
  181 ELELKDFVMK HRNEINAKEA ALATLKEAEN ELHKKLGQKA AEYEDLVQQH KKQQEELALM 240
  241 RSSKDEEITK LLDKCKNEVL LKQVAVNKLA EVMNRRDSDL PKQKNKARST AELRKKEKEM 300
  301 RRLQQELSQE RDKFNQLLLK H

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	19.154902
Match:	1i84S
Description:	Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #5

Region A:
Residues: [1072-1107]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QDLQQLCAEE QQLKQKMVME IDCKATEIEN LQSKLN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.69897
Match:	2i1jA
Description:	No description for 2i1jA was found.

Predicted Domain #6

Region A:
Residues: [1108-1253]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETASLSSADN DPEDSQHSSL LSLTQDSVFE GWLSVPNKQN RRRGHGWKRQ YVIVSSRKII  60
   61 FYNSDIDKHN TTDAVLILDL SKVYHVRSVT QGDVIRADAK EIPRIFQLLY AGEGASHRPD 120
  121 EQSQLDVSVL HGNCNEERPG TIVHKG

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	2.06
Match:	2coaA
Description:	Solution structure of the PH domain of protein kinase C, D2 type from human
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
actin binding	3.56545913943715	bayes_pls_golite062009
cytoskeletal protein binding	3.36168834560682	bayes_pls_golite062009
binding	3.16245771986829	bayes_pls_golite062009
protein binding	3.00808514157552	bayes_pls_golite062009
insulin receptor binding	2.60167278410043	bayes_pls_golite062009
transcription regulator activity	2.13588211069605	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	2.06185019777926	bayes_pls_golite062009
actin filament binding	1.91515281241149	bayes_pls_golite062009
DNA binding	1.80618207914839	bayes_pls_golite062009
phosphoinositide 3-kinase binding	1.63593384010249	bayes_pls_golite062009
nucleic acid binding	1.59061714977326	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.55414958698765	bayes_pls_golite062009
kinase activity	1.52393509273639	bayes_pls_golite062009
molecular transducer activity	1.51882027675546	bayes_pls_golite062009
signal transducer activity	1.51882027675546	bayes_pls_golite062009
GTPase regulator activity	1.50594272418871	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	1.48917924547615	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.39413069155432	bayes_pls_golite062009
protein kinase activity	1.36096357986245	bayes_pls_golite062009
transporter activity	1.29925758003665	bayes_pls_golite062009
receptor activity	1.18359632789069	bayes_pls_golite062009
Rho guanyl-nucleotide exchange factor activity	1.15172245597736	bayes_pls_golite062009
enzyme regulator activity	1.13267118951633	bayes_pls_golite062009
transmembrane receptor activity	1.12262165497943	bayes_pls_golite062009
SH2 domain binding	1.11962718814384	bayes_pls_golite062009
small GTPase regulator activity	1.10613306581585	bayes_pls_golite062009
transferase activity	1.09391396934652	bayes_pls_golite062009
enzyme binding	0.986198119454688	bayes_pls_golite062009
oxidoreductase activity	0.975799143332123	bayes_pls_golite062009
insulin-like growth factor receptor binding	0.902696448574164	bayes_pls_golite062009
receptor binding	0.898748069011275	bayes_pls_golite062009
phospholipid binding	0.864843473490307	bayes_pls_golite062009
receptor signaling protein activity	0.830314446783898	bayes_pls_golite062009
kinase binding	0.829679711601002	bayes_pls_golite062009
substrate-specific transporter activity	0.807688160227952	bayes_pls_golite062009
Ran GTPase binding	0.709291241748316	bayes_pls_golite062009
protein domain specific binding	0.650240628628722	bayes_pls_golite062009
protein serine/threonine kinase activity	0.62326150960884	bayes_pls_golite062009
guanyl-nucleotide exchange factor activity	0.578612934164552	bayes_pls_golite062009
small GTPase binding	0.56438433639766	bayes_pls_golite062009
protein kinase binding	0.557283580441975	bayes_pls_golite062009
GTPase binding	0.550421293582715	bayes_pls_golite062009
phosphoinositide binding	0.45899353522401	bayes_pls_golite062009
protein complex binding	0.424439033593144	bayes_pls_golite062009
structural molecule activity	0.332112521019418	bayes_pls_golite062009
structural constituent of cytoskeleton	0.328898130778985	bayes_pls_golite062009
G-protein-coupled receptor binding	0.0941284428910731	bayes_pls_golite062009
pyrophosphatase activity	0.0707105517897648	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0620154731603239	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.0594013389870999	bayes_pls_golite062009

Predicted Domain #7

Region A:
Residues: [1254-1314]

      1          11         21         31         41         51         
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    1 HEFVHITYHM PTACEVCPKP LWHMFKPPAA YECKRCRNKI HKEHVDKHDP LAPCKLNHDP  60
   61 R

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	13.39794
Match:	1tbnA
Description:	NMR STRUCTURE OF A PROTEIN KINASE C-G PHORBOL-BINDING DOMAIN, MINIMIZED AVERAGE STRUCTURE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
general RNA polymerase II transcription factor activity	4.00373045859121	bayes_pls_golite062009
transcription regulator activity	2.86705824967236	bayes_pls_golite062009
binding	2.79128751898373	bayes_pls_golite062009
GTPase regulator activity	2.70614727793157	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	2.68579854252375	bayes_pls_golite062009
protein binding	2.34145982999922	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	2.10625597744594	bayes_pls_golite062009
DNA binding	2.06132216820898	bayes_pls_golite062009
guanyl-nucleotide exchange factor activity	2.06038764955701	bayes_pls_golite062009
kinase activity	2.03632850156074	bayes_pls_golite062009
enzyme regulator activity	1.9750017471254	bayes_pls_golite062009
small GTPase regulator activity	1.95738547986197	bayes_pls_golite062009
nucleic acid binding	1.91441035614579	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.8531437045627	bayes_pls_golite062009
protein kinase activity	1.62921423829738	bayes_pls_golite062009
transferase activity	1.4550521488922	bayes_pls_golite062009
transcription factor activity	1.39657429296564	bayes_pls_golite062009
signal transducer activity	1.25507073225414	bayes_pls_golite062009
molecular transducer activity	1.25507073225414	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.10685156896266	bayes_pls_golite062009
Ras GTPase activator activity	1.09070479183477	bayes_pls_golite062009
Ras guanyl-nucleotide exchange factor activity	0.958295643211986	bayes_pls_golite062009
protein serine/threonine kinase activity	0.956859696337723	bayes_pls_golite062009
GTPase activator activity	0.717730683557543	bayes_pls_golite062009
kinase binding	0.494958567742569	bayes_pls_golite062009
enzyme activator activity	0.298334474872045	bayes_pls_golite062009
catalytic activity	0.194464246602439	bayes_pls_golite062009

Predicted Domain #8

Region A:
Residues: [1315-1390]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SARDMLLLAA TPEDQSLWVA RLLKRIQKSG YKAASYNNNS TDGSKISPSQ STRSSYKPYA  60
   61 VNVQRSATLP ANSSLK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	13.39794
Match:	2uzpA
Description:	No description for 2uzpA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions:

Predicted functions: