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Protein Overview: p53-PA, p53-PC

General Information:
Name(s) found: p53-PC / FBpp0290979 [FlyBase]
p53-PA / FBpp0083752 [FlyBase]
Description(s) found:
Found 39 descriptions.
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  • The gene p53 is referred to in FlyBase by the symbol Dmel\p53 (CG33336, FBgn0039044). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:18875379..18879804. It has the cytological map location 94D10. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence for 13 unique biological process</span> terms, many of which group under: response to radiation; response to DNA damage stimulus; response to abiotic stimulus; regulation of apoptosis; cell death; programmed cell death; positive regulation of programmed cell death; positive regulation of peptidase activity; positive regulation of cellular biosynthetic process; response to ionizing radiation; response to UV; determination of adult lifespan; anatomical structure development. 45 alleles are reported. The phenotypes of these alleles are annotated with: eye disc; eye; interommatidial bristle; pole cell; wing; outer photoreceptor cell; ommatidium. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene p53 is referred to in FlyBase by the symbol Dmel\p53 (CG33336, FBgn0039044). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:18875379..18879804. It has the cytological map location 94D10. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence for 13 unique biological process</span> terms, many of which group under: response to radiation; response to DNA damage stimulus; response to abiotic stimulus; regulation of apoptosis; cell death; programmed cell death; positive regulation of programmed cell death; positive regulation of peptidase activity; positive regulation of cellular biosynthetic process; response to ionizing radiation; response to UV; determination of adult lifespan; anatomical structure development. 45 alleles are reported. The phenotypes of these alleles are annotated with: eye disc; eye; interommatidial bristle; pole cell; wing; outer photoreceptor cell; ommatidium. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 385 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC][IEA]
    Biological Process: determination of adult lifespan [IMP]
    response to radiation [IMP][TAS]
    DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis [IMP][TAS]
    regulation of transcription, DNA-dependent [IEA]
    positive regulation of cell cycle [IGI]
    DNA damage response, signal transduction resulting in induction of apoptosis [TAS]
    response to UV [IMP]
    response to DNA damage stimulus [IDA][IMP]
    regulation of transcription [IEA]
    tissue regeneration [IMP]
    regulation of transcription from RNA polymerase II promoter [TAS]
    cell death [IMP]
    positive regulation of gene-specific transcription [IMP]
    apoptosis [IMP][TAS]
    DNA damage response, signal transduction by p53 class mediator [TAS]
    activation of caspase activity [IMP]
    response to ionizing radiation [IMP]
    Molecular Function: DNA binding [NAS]
    transcription factor activity [IEA][NAS]
    protein binding [IPI]
    RNA polymerase II transcription factor activity [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYISQPMSWH KESTDSEDDS TEVDIKEDIP KTVEVSGSEL TTEPMAFLQG LNSGNLMQFS  60
   61 QQSVLREMML QDIQIQANTL PKLENHNIGG YCFSMVLDEP PKSLWMYSIP LNKLYIRMNK 120
  121 AFNVDVQFKS KMPIQPLNLR VFLCFSNDVS APVVRCQNHL SVEPLTANNA KMRESLLRSE 180
  181 NPNSVYCGNA QGKGISERFS VVVPLNMSRS VTRSGLTRQT LAFKFVCQNS CIGRKETSLV 240
  241 FCLEKACGDI VGQHVIHVKI CTCPKRDRIQ DERQLNSKKR KSVPEAAEED EPSKVRRCIA 300
  301 IKTEDTESND SRDCDDSAAE WNVSRTPDGD YRLAITCPNK EWLLQSIEGM IKEAAAEVLR 360
  361 NPNQENLRRH ANKLLSLKKR AYELP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..320] PSI-BLAST 85.0 Crystal structure of the human p53 core domain mutant M133L/V203A/N239Y/N268D at 1.9 A resolution.
    2 View Details [321..385] MSA 6.060996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.42929256050781 bayes_pls_golite062009
  • DNA binding
    		•  5.31133900263778 bayes_pls_golite062009
  • nucleic acid binding
    		•  5.16722510757739 bayes_pls_golite062009
  • DNA strand annealing activity
    		•  4.57315860395948 bayes_pls_golite062009
  • transcription factor activity
    		•  4.50526425463039 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.91938513552138 bayes_pls_golite062009
  • transcription activator activity
    		•  3.89749713667575 bayes_pls_golite062009
  • binding
    		•  3.82913410895101 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.14317875446423 bayes_pls_golite062009
  • protein binding
    		•  2.61625563263605 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  2.36676277465674 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  2.30995267491835 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  1.96307110502121 bayes_pls_golite062009
  • chromatin binding
    		•  1.28001279726096 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.27337392672914 bayes_pls_golite062009
  • copper ion binding
    		•  1.24203749926155 bayes_pls_golite062009
  • transcription factor binding
    		•  0.628837188707778 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.35905469882415 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.0889583851427092 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle