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A cascade of processes induced by the detection of DNA damage within a cell. A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the initiation of apoptosis (programmed cell death). A cascade of processes initiated by the detection of DNA damage and resulting in the induction of apoptosis (programmed cell death). The series of molecular events whereby information is sent from one location to another within a cell. A process that directly activates any of the steps required for cell death by apoptosis. A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. Any process induced by intracellular signals that directly activates any of the steps required for cell death by apoptosis.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: DNA damage response, signal transduction resulting in induction of apoptosis
Acc: GO:0008630
Aspect: Biological Process
Desc: A cascade of processes initiated by the detection of DNA damage and resulting in the induction of apoptosis (programmed cell death).
Proteins in PDR annotated with:
   This term: 43 [Search]
   Term or descendants: 83 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0008630 - DNA damage response, signal transduction resulting in induction of apoptosis (interactive image map)
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