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Protein Overview: FBpp0306059, slmb-PA

General Information:
Name(s) found: FBpp0306059 [FlyBase]
slmb-PA / FBpp0083434 [FlyBase]
Description(s) found:
Found 32 descriptions.
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  • type=protein; loc=3R:complement(16946442..16946461,16946556..16946691,16946752..16946941,16947275..16947729,16947794..16947973,16948044..16948315,16950884..16951106,16952660..16952716); ID=FBpp0306059; name=slmb-PC; parent=FBgn0023423,FBtr0333931; dbxref=FlyBase:FBpp0306059,FlyBase_Annotation_IDs:CG3412-PC,REFSEQ:NP_001262801,GB_protein:AGB96181; MD5=ab5ded4aa88ccf5d8f7b1a3765b9a9f9; length=510; release=r5.56; species=Dmel; [FlyBase]
  • The gene supernumerary limbs is referred to in FlyBase by the symbol Dmel\slmb (CG3412, FBgn0023423). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:16944973..16953202. It has the cytological map location 93B13-93C1. There is experimental evidence that it has the molecular function</span>: phosphoprotein binding. There is experimental evidence for 19 unique biological process</span> terms, many of which group under: reproductive process in a multicellular organism; anatomical structure development; ovarian follicle cell development; regulation of biological process; circadian rhythm; multicellular organism reproduction; learning or memory; regulation of cellular component organization; olfactory learning; positive regulation of protein import into nucleus; locomotory behavior; catabolic process; negative regulation of nurse cell apoptosis; regulation of signal transduction; regulation of Wnt receptor signaling pathway. 43 alleles are reported. The phenotypes of these alleles are annotated with: first instar larva; leg; dorsal mesothoracic disc; mitotic cell cycle; haltere; wing; ventral thoracic disc. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 510 amino acids

    Gene Ontology:
    Cellular Component: ubiquitin ligase complex [ISS]
    SCF ubiquitin ligase complex [NAS][TAS]
    Biological Process: negative regulation of nurse cell apoptosis [IMP]
    germarium-derived egg chamber formation [IMP]
    regulation of mitosis [IMP]
    regulation of proteolysis [TAS]
    release of cytoplasmic sequestered NF-kappaB [IMP][TAS]
    germarium-derived female germ-line cyst encapsulation [IMP]
    dorsal appendage formation [IMP]
    olfactory learning [IMP]
    border follicle cell migration [IMP]
    circadian rhythm [IMP][IPI]
    chorion-containing eggshell formation [IMP]
    negative regulation of smoothened signaling pathway [IMP]
    regulation of smoothened signaling pathway [TAS]
    learning or memory [IMP]
    ovarian follicle cell stalk formation [IMP]
    germarium-derived female germ-line cyst formation [IMP]
    locomotor rhythm [IMP]
    ovarian follicle cell development [IMP]
    proteolysis [IMP]
    negative regulation of Wnt receptor signaling pathway [NAS]
    regulation of Wnt receptor signaling pathway [IMP][TAS]
    negative regulation of transforming growth factor beta receptor signaling pathway [NAS]
    oocyte localization during germarium-derived egg chamber formation [IMP]
    Molecular Function: ubiquitin-protein ligase activity [ISS]
    phosphoprotein binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMKMETDKIM DETNSNAQAF TTTMLYDPVR KKDSSPTYQT ERELCFQYFT QWSESGQVDF  60
   61 VEHLLSRMCH YQHGQINAYL KPMLQRDFIT LLPIKGLDHI AENILSYLDA ESLKSSELVC 120
  121 KEWLRVISEG MLWKKLIERK VRTDSLWRGL AERRNWMQYL FKPRPGQTQR PHSFHRELFP 180
  181 KIMNDIDSIE NNWRTGRHML RRINCRSENS KGVYCLQYDD GKIVSGLRDN TIKIWDRTDL 240
  241 QCVKTLMGHT GSVLCLQYDD KVIISGSSDS TVRVWDVNTG EMVNTLIHHC EAVLHLRFNN 300
  301 GMMVTCSKDR SIAVWDMTSP SEITLRRVLV GHRAAVNVVD FDEKYIVSAS GDRTIKVWST 360
  361 SSCEFVRTLN GHKRGIACLQ YRDRLVVSGS SDNSIRLWDI ECGACLRVLE GHEELVRCIR 420
  421 FDTKRIVSGA YDGKIKVWDL VAALDPRAAS NTLCLNTLVE HTGRVFRLQF DEFQIVSSSH 480
  481 DDTILIWDFL NFTPNENKTG RTPSPALMEH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..91] PSI-BLAST 7.69897 Structure of the apoptotic protease-activating factor 1 bound to ADP
    2 View Details [92..510] PSI-BLAST 97.69897 F-box/WD-repeat protein 1 (beta-TRCP1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  7.6976390971701 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  7.38724968585043 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  6.41826641115519 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  5.36089569430187 bayes_pls_golite062009
  • actin binding
    		•  3.86142918698875 bayes_pls_golite062009
  • GTPase activity
    		•  3.23750443966606 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.1056443224755 bayes_pls_golite062009
  • tubulin binding
    		•  2.76945430061825 bayes_pls_golite062009
  • microtubule binding
    		•  2.72684103222924 bayes_pls_golite062009
  • dynein binding
    		•  2.54821997913979 bayes_pls_golite062009
  • binding
    		•  2.42570478946173 bayes_pls_golite062009
  • actin filament binding
    		•  2.0735069176589 bayes_pls_golite062009
  • dynactin binding
    		•  1.92897254169098 bayes_pls_golite062009
  • ligase activity
    		•  1.82531515493699 bayes_pls_golite062009
  • peroxisome targeting sequence binding
    		•  1.73465159850484 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.63776917287392 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  1.63631972867316 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56901113625383 bayes_pls_golite062009
  • protein binding
    		•  1.21879977456466 bayes_pls_golite062009
  • transporter activity
    		•  1.21549336905926 bayes_pls_golite062009
  • receptor activity
    		•  1.12819778129653 bayes_pls_golite062009
  • DNA binding
    		•  1.0776875611211 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  1.01166033978052 bayes_pls_golite062009
  • myosin binding
    		•  0.989691178611801 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.974380908248463 bayes_pls_golite062009
  • signal transducer activity
    		•  0.974380908248463 bayes_pls_golite062009
  • protein transporter activity
    		•  0.964340340346761 bayes_pls_golite062009
  • angiotensin receptor binding
    		•  0.920323565472959 bayes_pls_golite062009
  • type 1 angiotensin receptor binding
    		•  0.920323565472959 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.826090766828089 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.734793983890004 bayes_pls_golite062009
  • transcription factor activity
    		•  0.541665384827041 bayes_pls_golite062009
  • dynein intermediate chain binding
    		•  0.443846546939402 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.43316396073854 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.426429095658617 bayes_pls_golite062009
  • kinase activity
    		•  0.387572734234845 bayes_pls_golite062009
  • receptor binding
    		•  0.316169754698691 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.259860754265901 bayes_pls_golite062009
  • structural molecule activity
    		•  0.254012051644049 bayes_pls_golite062009
  • transcription factor binding
    		•  0.244641056034795 bayes_pls_golite062009
  • myosin heavy chain kinase activity
    		•  0.231534552000461 bayes_pls_golite062009
  • protein kinase activity
    		•  0.229242350006544 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.226335610368636 bayes_pls_golite062009
  • hydrolase activity
    		•  0.181211933860468 bayes_pls_golite062009
  • histone binding
    		•  0.166694897714113 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.118975415284669 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.0160791658499004 bayes_pls_golite062009
  • myosin II binding
    		•  0.0145748031956598 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.00585398682921312 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle