YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Any process that stops, prevents or reduces the frequency, rate or extent of a signaling pathway. Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment. Any process that modulates the frequency, rate or extent of a signaling pathway. Any process that modulates the frequency, rate or extent of smoothened signaling. The series of molecular events whereby information is sent from one location to another within a living organism or between living organisms. Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling. Any process that stops, prevents or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell. Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling that is involved in the patterns of cell differentiation in the ventral spinal cord. The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of smoothened signaling pathway
Acc: GO:0045879
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of smoothened signaling.
Synonyms:
  • downregulation of smoothened signaling pathway
  • negative regulation of smoothened activity
  • negative regulation of smoothened by patched
  • negative regulation of hh signaling pathway
  • negative regulation of smoothened signalling pathway
  • down regulation of smoothened signaling pathway
  • negative regulation of hedgehog signaling pathway
  • down-regulation of smoothened signaling pathway
  • inhibition of smoothened signaling pathway
  • negative regulation of smoothened receptor activity by patched
  • GO:0045877
Proteins in PDR annotated with:
   This term: 32 [Search]
   Term or descendants: 34 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0045879 - negative regulation of smoothened signaling pathway (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle