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Protein Overview: FBpp0310841, FBp...

General Information:
Name(s) found: FBpp0311050 [FlyBase]
FBpp0310841 [FlyBase]
Akt1-PA / FBpp0082681 [FlyBase]
Akt1-PB / FBpp0082680 [FlyBase]
Description(s) found:
Found 48 descriptions.
SHOW ALL
  • type=protein; loc=3R:join(11926909..11927448,11927517..11927714,11927780..11928169,11928233..11928466,11928535..11928681,11928753..11928836); ID=FBpp0311050; name=Akt1-PE; parent=FBgn0010379,FBtr0344717; dbxref=FlyBase:FBpp0311050,FlyBase_Annotation_IDs:CG4006-PE; MD5=2b5b2f536a63100fa07df0a86755b34c; length=530; release=r5.56; species=Dmel; [FlyBase]
  • type=protein; loc=3R:join(11926909..11927448,11927517..11927714,11927780..11928169,11928233..11928466,11928535..11928681,11928753..11928836); ID=FBpp0310841; name=Akt1-PD; parent=FBgn0010379,FBtr0344470; dbxref=FlyBase:FBpp0310841,FlyBase_Annotation_IDs:CG4006-PD; MD5=2b5b2f536a63100fa07df0a86755b34c; length=530; release=r5.56; species=Dmel; [FlyBase]
  • The gene Akt1 is referred to in FlyBase by the symbol Dmel\Akt1 (CG4006, FBgn0010379). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:11924938..11930239. It has the cytological map location 89B3. There is experimental evidence that it has the molecular function</span>: protein serine/threonine kinase activity; protein kinase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of cell shape; intracellular signaling cascade; positive regulation of cell growth; insulin receptor signaling pathway; anti-apoptosis; positive regulation of cell size; protein amino acid phosphorylation; lipid storage; open tracheal system development; chitin-based embryonic cuticle biosynthetic process. 30 alleles are reported. The phenotypes of these alleles are annotated with: embryonic trachea; larval salivary gland; eye; dorsal mesothoracic disc; 1st posterior cell; interommatidial bristle; wing; ommatidium; wing vein; wing hair. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene Akt1 is referred to in FlyBase by the symbol Dmel\Akt1 (CG4006, FBgn0010379). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:11924938..11930239. It has the cytological map location 89B3. There is experimental evidence that it has the molecular function</span>: protein serine/threonine kinase activity; protein kinase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of cell shape; intracellular signaling cascade; positive regulation of cell growth; insulin receptor signaling pathway; anti-apoptosis; positive regulation of cell size; protein amino acid phosphorylation; lipid storage; open tracheal system development; chitin-based embryonic cuticle biosynthetic process. 30 alleles are reported. The phenotypes of these alleles are annotated with: embryonic trachea; larval salivary gland; eye; dorsal mesothoracic disc; 1st posterior cell; interommatidial bristle; wing; ommatidium; wing vein; wing hair. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 530 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSINTTFDLS SPSVTSGHAL TEQTQVVKEG WLMKRGEHIK NWRQRYFVLH SDGRLMGYRS  60
   61 KPADSASTPS DFLLNNFTVR GCQIMTVDRP KPFTFIIRGL QWTTVIERTF AVESELERQQ 120
  121 WTEAIRNVSS RLIDVGEVAM TPSEQTDMTD VDMATIAEDE LSEQFSVQGT TCNSSGVKKV 180
  181 TLENFEFLKV LGKGTFGKVI LCREKATAKL YAIKILKKEV IIQKDEVAHT LTESRVLKST 240
  241 NHPFLISLKY SFQTNDRLCF VMQYVNGGEL FWHLSHERIF TEDRTRFYGA EIISALGYLH 300
  301 SQGIIYRDLK LENLLLDKDG HIKVADFGLC KEDITYGRTT KTFCGTPEYL APEVLDDNDY 360
  361 GQAVDWWGTG VVMYEMICGR LPFYNRDHDV LFTLILVEEV KFPRNITDEA KNLLAGLLAK 420
  421 DPKKRLGGGK DDVKEIQAHP FFASINWTDL VLKKIPPPFK PQVTSDTDTR YFDKEFTGES 480
  481 VELTPPDPTG PLGSIAEEPL FPQFSYQGDM ASTLGTSSHI STSTSLASMQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..444] PSI-BLAST 60.69897 CHICKEN SRC TYROSINE KINASE
    2 View Details [445..530] PSI-BLAST 101.0 No description for 2jdoA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • cyclic nucleotide-dependent protein kinase activity
    		•  4.97855712164511 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cAMP-dependent protein kinase activity
    		•  4.66277812893755 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  3.41480681854114 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  2.8153155526437 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  2.79505438761262 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.52531786618214 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.46424348876434 bayes_pls_golite062009
  • signal transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.40586892801446 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.37122853419919 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.10379226653669 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.94085498993561 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.9016235206634 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • actin binding
    		•  1.87817875565699 bayes_pls_golite062009
  • acetylcholine receptor activator activity
    		•  1.83545227594542 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.74206248731815 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • JUN kinase kinase kinase kinase activity
    		•  1.55257528159541 bayes_pls_golite062009
  • growth factor binding
    		•  1.53863828216563 bayes_pls_golite062009
  • phosphoinositide 3-kinase activity
    		•  1.5013287968167 bayes_pls_golite062009
  • 1-phosphatidylinositol-3-kinase activity
    		•  1.43713739644553 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  1.42275431028856 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • PTB domain binding
    		•  1.33588583294761 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.32254739984688 bayes_pls_golite062009
  • kinase binding
    		•  1.26086833316556 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  1.25765701903393 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  1.24312972088703 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.2266791546014 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.16049201286103 bayes_pls_golite062009
  • type II transforming growth factor beta receptor binding
    		•  1.15601343883601 bayes_pls_golite062009
  • transporter activity
    		•  1.11833481501707 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • structural molecule activity
    		•  1.10436308210353 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  1.10045286406485 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  1.10045286406485 bayes_pls_golite062009
  • protein kinase binding
    		•  1.06030596516506 bayes_pls_golite062009
  • cation channel activity
    		•  1.04999722123563 bayes_pls_golite062009
  • phosphoinositide 3-kinase regulator activity
    		•  1.03150090191995 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.97575992765505 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.959360414036299 bayes_pls_golite062009
  • telethonin binding
    		•  0.953133636042811 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.872782211382796 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • actin filament binding
    		•  0.794152600084 bayes_pls_golite062009
  • platelet-derived growth factor receptor binding
    		•  0.770658204347392 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.75189004129952 bayes_pls_golite062009
  • transcription activator activity
    		•  0.746097961522136 bayes_pls_golite062009
  • fibroblast growth factor binding
    		•  0.728507215600658 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.705905455086486 bayes_pls_golite062009
  • vinculin binding
    		•  0.666656406096231 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • insulin receptor activity
    		•  0.585036697436369 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.568332175782799 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  0.547121592096699 bayes_pls_golite062009
  • fibroblast growth factor 1 binding
    		•  0.537170519944039 bayes_pls_golite062009
  • activin binding
    		•  0.510364757301021 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • enzyme binding
    		•  0.46284745266176 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • cyclin-dependent protein kinase regulator activity
    		•  0.406297251827056 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • phosphotyrosine binding
    		•  0.311079584914389 bayes_pls_golite062009
  • channel activity
    		•  0.287189255116606 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.287189255116606 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.266450215230107 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.261869836686301 bayes_pls_golite062009
  • ion channel activity
    		•  0.241519346930618 bayes_pls_golite062009
  • protein complex binding
    		•  0.239339759110451 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.226760162354251 bayes_pls_golite062009
  • insulin binding
    		•  0.147382876071569 bayes_pls_golite062009
  • peptide binding
    		•  0.118578378753757 bayes_pls_golite062009
  • alpha-actinin binding
    		•  0.0923798087054641 bayes_pls_golite062009
  • JUN kinase kinase kinase activity
    		•  0.0613131034808199 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.0506751594607393 bayes_pls_golite062009
  • MAP kinase kinase kinase kinase activity
    		•  0.01826424351081 bayes_pls_golite062009
  • nitric-oxide synthase regulator activity
    		•  0.00407218246327123 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.85

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle