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Protein Overview: sad-PA

General Information:
Name(s) found: sad-PA / FBpp0081949 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene shadow is referred to in FlyBase by the symbol Dmel\sad (CG14728, FBgn0003312). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:7702957..7705476. It has the cytological map location 87A1. There is experimental evidence that it has the molecular function</span>: ecdysteroid 2-hydroxylase activity. There is experimental evidence that it is involved in the biological process</span>: central nervous system development; dorsal closure; ecdysone biosynthetic process; head involution; midgut development. 14 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: organ system; nervous system; anatomical structure; embryonic nervous system; integumentary system; multi-cell-component structure; portion of tissue; cuticle; embryonic central nervous system; cephalopharyngeal skeleton; commissure. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 520 amino acids

    Gene Ontology:
    Cellular Component: membrane [NAS]
    mitochondrion [IDA][ISS]
    Biological Process: dorsal closure [IMP]
    central nervous system development [IMP]
    midgut development [IMP]
    head involution [IMP]
    oxidation reduction [IEA]
    ecdysone biosynthetic process [IDA]
    Molecular Function: ecdysteroid 2-hydroxylase activity [IDA]
    electron carrier activity [IEA][ISS][NAS]
    heme binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEKRERPGP LRWLRHLLDQ LLVRILSLSL FRSRCDPPPL QRFPATELPP AVAAKYVPIP  60
   61 RVKGLPVVGT LVDLIAAGGA THLHKYIDAR HKQYGPIFRE RLGGTQDAVF VSSANLMRGV 120
  121 FQHEGQYPQH PLPDAWTLYN QQHACQRGLF FMEGAEWLHN RRILNRLLLN GNLNWMDVHI 180
  181 ESCTRRMVDQ WKRRTAEAAA IPLAESGEIR SYELPLLEQQ LYRWSIEVLC CIMFGTSVLT 240
  241 CPKIQSSLDY FTQIVHKVFE HSSRLMTFPP RLAQILRLPI WRDFEANVDE VLREGAAIID 300
  301 HCIRVQEDQR RPHDEALYHR LQAADVPGDM IKRIFVDLVI AAGDTTAFSS QWALFALSKE 360
  361 PRLQQRLAKE RATNDSRLMH GLIKESLRLY PVAPFIGRYL PQDAQLGGHF IEKDTMVLLS 420
  421 LYTAGRDPSH FEQPERVLPE RWCIGETEQV HKSHGSLPFA IGQRSCIGRR VALKQLHSLL 480
  481 GRCAAQFEMS CLNEMPVDSV LRMVTVPDRT LRLALRPRTE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..520] PSI-BLAST 87.221849 Crystal Structure of Human Microsomal P450 3A4

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • arachidonic acid monooxygenase activity
    		•  6.76823710927794 bayes_pls_golite062009
  • monooxygenase activity
    		•  5.57229509004705 bayes_pls_golite062009
  • steroid hydroxylase activity
    		•  5.04794778387361 bayes_pls_golite062009
  • arachidonic acid epoxygenase activity
    		•  4.80764258881036 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen
    		•  4.64322346579269 bayes_pls_golite062009
  • steroid 17-alpha-monooxygenase activity
    		•  3.99744233006162 bayes_pls_golite062009
  • oxygen binding
    		•  3.7203678182299 bayes_pls_golite062009
  • demethylase activity
    		•  3.40807632433846 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
    		•  3.24344797738248 bayes_pls_golite062009
  • sterol 14-demethylase activity
    		•  2.94610675710811 bayes_pls_golite062009
  • corticosterone 18-monooxygenase activity
    		•  2.69642243567771 bayes_pls_golite062009
  • steroid 11-beta-monooxygenase activity
    		•  2.69642243567771 bayes_pls_golite062009
  • retinoic acid 4-hydroxylase activity
    		•  2.60901411823382 bayes_pls_golite062009
  • oxysterol 7-alpha-hydroxylase activity
    		•  2.36480328243514 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.35847923992364 bayes_pls_golite062009
  • 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
    		•  2.30416050662077 bayes_pls_golite062009
  • ecdysteroid 25-hydroxylase activity
    		•  2.0071742914584 bayes_pls_golite062009
  • retinoid binding
    		•  1.91237853759594 bayes_pls_golite062009
  • vitamin D 24-hydroxylase activity
    		•  1.81919676974797 bayes_pls_golite062009
  • isoprenoid binding
    		•  1.78853880472253 bayes_pls_golite062009
  • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
    		•  1.71400598599521 bayes_pls_golite062009
  • oxidoreductase activity, acting on diphenols and related substances as donors
    		•  1.70263392462058 bayes_pls_golite062009
  • retinoic acid binding
    		•  1.69236715381231 bayes_pls_golite062009
  • vitamin D3 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • vitamin D 25-hydroxylase activity
    		•  1.65825585934141 bayes_pls_golite062009
  • fatty acid (omega-1)-hydroxylase activity
    		•  1.65569090470706 bayes_pls_golite062009
  • ecdysteroid 22-hydroxylase activity
    		•  1.58167166311061 bayes_pls_golite062009
  • electron carrier activity
    		•  1.48516712188486 bayes_pls_golite062009
  • testosterone 6-beta-hydroxylase activity
    		•  1.4661447981611 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  1.42927429551354 bayes_pls_golite062009
  • steroid 7-alpha-hydroxylase activity
    		•  1.42366670093448 bayes_pls_golite062009
  • transition metal ion binding
    		•  1.39485992496073 bayes_pls_golite062009
  • binding
    		•  1.2866152532988 bayes_pls_golite062009
  • 25-hydroxycholecalciferol-24-hydroxylase activity
    		•  1.06487564122685 bayes_pls_golite062009
  • iron ion binding
    		•  1.05714805569149 bayes_pls_golite062009
  • cation binding
    		•  0.934330913850428 bayes_pls_golite062009
  • metal ion binding
    		•  0.934330913850428 bayes_pls_golite062009
  • ion binding
    		•  0.927080243591876 bayes_pls_golite062009
  • protein binding
    		•  0.836411857417911 bayes_pls_golite062009
  • catalytic activity
    		•  0.608111453189583 bayes_pls_golite062009
  • cholesterol monooxygenase (side-chain-cleaving) activity
    		•  0.276594551871869 bayes_pls_golite062009
  • arachidonic acid 11,12-epoxygenase activity
    		•  0.0888154993183798 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.65

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle