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View Structure Prediction Details

Protein: sad-PA
Organism: Drosophila melanogaster
Length: 520 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sad-PA.

Description E-value Query
Range		 Subject
Range
gi|115496944, gi... - gi|94574282|gb|AAI16042.1| Cytochrome P450, family 2, subfamily C, polypeptide 18 [Bos taurus], gi|1...
 351.0 [0..49] [517..20]

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Predicted Domain #1
Region A:
Residues: [1-520] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEKRERPGP LRWLRHLLDQ LLVRILSLSL FRSRCDPPPL QRFPATELPP AVAAKYVPIP  60
   61 RVKGLPVVGT LVDLIAAGGA THLHKYIDAR HKQYGPIFRE RLGGTQDAVF VSSANLMRGV 120
  121 FQHEGQYPQH PLPDAWTLYN QQHACQRGLF FMEGAEWLHN RRILNRLLLN GNLNWMDVHI 180
  181 ESCTRRMVDQ WKRRTAEAAA IPLAESGEIR SYELPLLEQQ LYRWSIEVLC CIMFGTSVLT 240
  241 CPKIQSSLDY FTQIVHKVFE HSSRLMTFPP RLAQILRLPI WRDFEANVDE VLREGAAIID 300
  301 HCIRVQEDQR RPHDEALYHR LQAADVPGDM IKRIFVDLVI AAGDTTAFSS QWALFALSKE 360
  361 PRLQQRLAKE RATNDSRLMH GLIKESLRLY PVAPFIGRYL PQDAQLGGHF IEKDTMVLLS 420
  421 LYTAGRDPSH FEQPERVLPE RWCIGETEQV HKSHGSLPFA IGQRSCIGRR VALKQLHSLL 480
  481 GRCAAQFEMS CLNEMPVDSV LRMVTVPDRT LRLALRPRTE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 87.221849
Match: 1tqnA
Description: Crystal Structure of Human Microsomal P450 3A4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
arachidonic acid monooxygenase activity 6.76823710927794 bayes_pls_golite062009
monooxygenase activity 5.57229509004705 bayes_pls_golite062009
steroid hydroxylase activity 5.04794778387361 bayes_pls_golite062009
arachidonic acid epoxygenase activity 4.80764258881036 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen 4.64322346579269 bayes_pls_golite062009
steroid 17-alpha-monooxygenase activity 3.99744233006162 bayes_pls_golite062009
oxygen binding 3.7203678182299 bayes_pls_golite062009
demethylase activity 3.40807632433846 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3.24344797738248 bayes_pls_golite062009
sterol 14-demethylase activity 2.94610675710811 bayes_pls_golite062009
corticosterone 18-monooxygenase activity 2.69642243567771 bayes_pls_golite062009
steroid 11-beta-monooxygenase activity 2.69642243567771 bayes_pls_golite062009
retinoic acid 4-hydroxylase activity 2.60901411823382 bayes_pls_golite062009
oxysterol 7-alpha-hydroxylase activity 2.36480328243514 bayes_pls_golite062009
oxidoreductase activity 2.35847923992364 bayes_pls_golite062009
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity 2.30416050662077 bayes_pls_golite062009
ecdysteroid 25-hydroxylase activity 2.0071742914584 bayes_pls_golite062009
retinoid binding 1.91237853759594 bayes_pls_golite062009
vitamin D 24-hydroxylase activity 1.81919676974797 bayes_pls_golite062009
isoprenoid binding 1.78853880472253 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 1.71400598599521 bayes_pls_golite062009
oxidoreductase activity, acting on diphenols and related substances as donors 1.70263392462058 bayes_pls_golite062009
retinoic acid binding 1.69236715381231 bayes_pls_golite062009
vitamin D3 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
vitamin D 25-hydroxylase activity 1.65825585934141 bayes_pls_golite062009
fatty acid (omega-1)-hydroxylase activity 1.65569090470706 bayes_pls_golite062009
ecdysteroid 22-hydroxylase activity 1.58167166311061 bayes_pls_golite062009
electron carrier activity 1.48516712188486 bayes_pls_golite062009
testosterone 6-beta-hydroxylase activity 1.4661447981611 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH 1.42927429551354 bayes_pls_golite062009
steroid 7-alpha-hydroxylase activity 1.42366670093448 bayes_pls_golite062009
transition metal ion binding 1.39485992496073 bayes_pls_golite062009
binding 1.2866152532988 bayes_pls_golite062009
25-hydroxycholecalciferol-24-hydroxylase activity 1.06487564122685 bayes_pls_golite062009
iron ion binding 1.05714805569149 bayes_pls_golite062009
cation binding 0.934330913850428 bayes_pls_golite062009
metal ion binding 0.934330913850428 bayes_pls_golite062009
ion binding 0.927080243591876 bayes_pls_golite062009
protein binding 0.836411857417911 bayes_pls_golite062009
catalytic activity 0.608111453189583 bayes_pls_golite062009
cholesterol monooxygenase (side-chain-cleaving) activity 0.276594551871869 bayes_pls_golite062009
arachidonic acid 11,12-epoxygenase activity 0.0888154993183798 bayes_pls_golite062009
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