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Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: steroid 17-alpha-monooxygenase activity
Acc: GO:0004508
Aspect: Molecular Function
Desc: Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O.
Synonyms:
  • steroid 17alpha-monooxygenase activity
  • steroid 17alpha-hydroxylase activity
  • steroid 17-alpha-hydroxylase/17,20 lyase activity
  • cytochrome P-450 (P-45017alpha,lyase)
  • 17alpha-hydroxylase-C17,20 lyase activity
  • steroid 17-alpha-hydroxylase-C17-20 lyase activity
  • steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)
  • cytochrome P45017alpha
  • cytochrome P450 CYP17
  • cytochrome p450 XVIIA1 activity
  • steroid 17-alpha-hydroxylase activity
  • steroid 17alphahydroxylase/17,20 lyase activity
Proteins in PDR annotated with:
   This term: 3 [Search]
   Term or descendants: 3 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004508 - steroid 17-alpha-monooxygenase activity (interactive image map)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle