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Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol). Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. Catalysis of the hydroxylation of C-24 of any form of vitamin D. Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. Catalysis of the hydroxylation of C-24 of 25-hydroxycholecalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycholecalciferol.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: vitamin D 24-hydroxylase activity
Acc: GO:0070576
Aspect: Molecular Function
Desc: Catalysis of the hydroxylation of C-24 of any form of vitamin D.
Synonyms:
  • ergocalciferol 24-hydroxylase activity
  • calciferol 24-hydroxylase activity
  • cholecalciferol 24-hydroxylase activity
  • vitamin D2 24-hydroxylase activity
  • vitamin D3 24-hydroxylase activity
Proteins in PDR annotated with:
   This term: 6 [Search]
   Term or descendants: 7 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0070576 - vitamin D 24-hydroxylase activity (interactive image map)

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