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Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. Catalysis of the removal of a methyl group from a substrate. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. Catalysis of the reaction: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP+ + 3 H2O. Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: sterol 14-demethylase activity
Acc: GO:0008398
Aspect: Molecular Function
Desc: Catalysis of the reaction: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP+ + 3 H2O.
Synonyms:
  • cytochrome P450 CYP51
  • lanosterol 14-demethylase activity
  • sterol 14-alpha-demethylase activity
  • lanosterol 14-alpha-demethylase activity
  • lanosterol 14alpha-demethylase activity
  • cytochrome P450 51 activity
  • sterol 14alpha-demethylase activity
  • obtusufoliol 14-demethylase activity
  • sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving)
Proteins in PDR annotated with:
   This term: 5 [Search]
   Term or descendants: 5 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0008398 - sterol 14-demethylase activity (interactive image map)

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Created and Maintained by: Michael Riffle