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Protein Overview: Csk-PI, Csk-PK, ...

General Information:
Name(s) found: Csk-PK / FBpp0289776 [FlyBase]
Csk-PJ / FBpp0289775 [FlyBase]
Csk-PI / FBpp0289774 [FlyBase]
Csk-PF / FBpp0289006 [FlyBase]
Description(s) found:
Found 60 descriptions.
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  • The gene C-terminal Src kinase is referred to in FlyBase by the symbol Dmel\Csk (CG42317, FBgn0259217). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:7458992..7476418. It has the cytological map location 86E13. There is experimental evidence that it has the molecular function</span>: protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process</span>: negative regulation of growth; adherens junction maintenance; positive regulation of programmed cell death; establishment or maintenance of epithelial cell apical/basal polarity; epithelial structure maintenance; negative regulation of cell proliferation; germarium-derived egg chamber formation. 27 alleles are reported. The phenotypes of these alleles are annotated with: eye; dorsal mesothoracic disc; anterior crossvein; wing vein L4; wing; ommatidium. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • The gene C-terminal Src kinase is referred to in FlyBase by the symbol Dmel\Csk (CG42317, FBgn0259217). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:7458992..7476418. It has the cytological map location 86E13. There is experimental evidence that it has the molecular function</span>: protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process</span>: negative regulation of growth; adherens junction maintenance; positive regulation of programmed cell death; establishment or maintenance of epithelial cell apical/basal polarity; epithelial structure maintenance; negative regulation of cell proliferation; germarium-derived egg chamber formation. 27 alleles are reported. The phenotypes of these alleles are annotated with: eye; dorsal mesothoracic disc; anterior crossvein; wing vein L4; wing; ommatidium. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • The gene C-terminal Src kinase is referred to in FlyBase by the symbol Dmel\Csk (CG42317, FBgn0259217). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:7458992..7476418. It has the cytological map location 86E13. There is experimental evidence that it has the molecular function</span>: protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process</span>: negative regulation of growth; adherens junction maintenance; positive regulation of programmed cell death; establishment or maintenance of epithelial cell apical/basal polarity; epithelial structure maintenance; negative regulation of cell proliferation; germarium-derived egg chamber formation. 27 alleles are reported. The phenotypes of these alleles are annotated with: eye; dorsal mesothoracic disc; anterior crossvein; wing vein L4; wing; ommatidium. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • The gene C-terminal Src kinase is referred to in FlyBase by the symbol Dmel\Csk (CG42317, FBgn0259217). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:7458992..7476418. It has the cytological map location 86E13. There is experimental evidence that it has the molecular function</span>: protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process</span>: negative regulation of growth; adherens junction maintenance; positive regulation of programmed cell death; establishment or maintenance of epithelial cell apical/basal polarity; epithelial structure maintenance; negative regulation of cell proliferation; germarium-derived egg chamber formation. 27 alleles are reported. The phenotypes of these alleles are annotated with: eye; dorsal mesothoracic disc; anterior crossvein; wing vein L4; wing; ommatidium. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 723 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEA]
    Biological Process: negative regulation of growth [IGI][IMP]
    germarium-derived egg chamber formation [IMP]
    intracellular signaling pathway [IEA]
    epithelial structure maintenance [IMP]
    negative regulation of cell proliferation [IMP]
    establishment or maintenance of epithelial cell apical/basal polarity [IMP]
    positive regulation of programmed cell death [IMP]
    adherens junction maintenance [IMP]
    protein amino acid phosphorylation [IEA][NAS]
    Molecular Function: ATP binding [IEA]
    protein tyrosine kinase activity [IDA][ISS][NAS]
    protein binding [IEA]
    non-membrane spanning protein tyrosine kinase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSHATATQN GQTTVVGHHR GFSQPSVTVA AAAATGSTAG DPWFLQTTGH QMPPTAPLRH  60
   61 NKRPAPQPNA VLGAGSSGTA PGSAVGAVLL HQQQLSQSQP HIVPPSIPPH HHHHRENNVH 120
  121 PIQAGAAAAL HLSSHALNSH NLISSASNHS PKSPSQTQQQ QQTTNQQQQQ QQQQASHSIL 180
  181 STFAPAPTVA AVQPAGSQSV AGTAAAVAAV AQQQQQQHLQ LLANCPPGGA GLMSSSLNAA 240
  241 QMGMHGAERA LPPKSLALSG SQHGSNMLLH TAPQPPQASQ PAAVVGVSGS GSAGMSTSLH 300
  301 SFDINGVTAG SGVNASSAWS SGSTTAMNHA SLSPTALAPQ QGRSRCEVKL NAMPWFHGSI 360
  361 TRDEAEHLLQ PREDGLFLVR ESTNFPGDYT LCVCFQSKVE HYRVKYLENK LTIDDEEYFE 420
  421 NLGQLVAHYE ADADGLCTQL IKCLPKLGKQ EFCINSKDFV DKGWVIPEAE LQLRESIGKG 480
  481 EFGDVMLGIL RNEKVAVKML KDEGAVQKFL AEASVMTTLE HDNLVKFIGL VFTSKHLYLV 540
  541 TEYMSKGSLV DYLRSRGRQH ITKKDQIIFA YDTASGMEYL EAKKVVHRDL AARNVLISED 600
  601 CVAKVSDFGL AREECYNLDV GKLPIKWTAP EALKNGRFSN KSDMWSFGIL LWEIYSFGRV 660
  661 PYPRIPLADV VKHVEVGYKM EAPEGCPPEI YEMMRQAWDL NPAKRPTFAE LKVKLQLLNN 720
  721 ATA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..100] deduced N/A No confident structure predictions are available.
    2 View Details [101..273] deduced N/A No confident structure predictions are available.
    3 View Details [274..723] PSI-BLAST 92.69897 Carboxyl-terminal src kinase (csk)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  4.41722924924158 bayes_pls_golite062009
  • actin binding
    		•  3.91045208670052 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  3.43994026029707 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  3.41480681854114 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  3.40140621607334 bayes_pls_golite062009
  • CD8 receptor binding
    		•  3.34636716492159 bayes_pls_golite062009
  • protein binding
    		•  3.19631993182765 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.13508395312263 bayes_pls_golite062009
  • signal transducer activity
    		•  3.13508395312263 bayes_pls_golite062009
  • binding
    		•  3.12724619324809 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  2.9751846707539 bayes_pls_golite062009
  • insulin receptor binding
    		•  2.73485644242393 bayes_pls_golite062009
  • actin filament binding
    		•  2.72908433443928 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.65451266834284 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  2.59526003830791 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.4913932444423 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.46424348876434 bayes_pls_golite062009
  • receptor activity
    		•  2.39311927684508 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.9016235206634 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.85015570449703 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.81249386965144 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.81145713371725 bayes_pls_golite062009
  • kinase activity
    		•  1.78069536883109 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine kinase activity
    		•  1.66669268613198 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • vinculin binding
    		•  1.63216315345235 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.59739467025045 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.59474164216385 bayes_pls_golite062009
  • PTB domain binding
    		•  1.56656184134104 bayes_pls_golite062009
  • growth factor binding
    		•  1.53863828216563 bayes_pls_golite062009
  • receptor binding
    		•  1.52843393025918 bayes_pls_golite062009
  • protein kinase activity
    		•  1.4654611643382 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  1.42275431028856 bayes_pls_golite062009
  • transporter activity
    		•  1.30447542854757 bayes_pls_golite062009
  • transferase activity
    		•  1.19152443245584 bayes_pls_golite062009
  • tubulin binding
    		•  1.13686658158825 bayes_pls_golite062009
  • transforming growth factor beta receptor activity
    		•  1.10045286406485 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase activity
    		•  1.10045286406485 bayes_pls_golite062009
  • SH2 domain binding
    		•  1.09679619057368 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.08558010881058 bayes_pls_golite062009
  • cation channel activity
    		•  1.04999722123563 bayes_pls_golite062009
  • structural molecule activity
    		•  0.989403012920596 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.820987609295422 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.81943579965027 bayes_pls_golite062009
  • fibroblast growth factor receptor activity
    		•  0.75189004129952 bayes_pls_golite062009
  • microtubule binding
    		•  0.734274677384472 bayes_pls_golite062009
  • protein complex binding
    		•  0.65988681496356 bayes_pls_golite062009
  • protein phosphorylated amino acid binding
    		•  0.649814096718101 bayes_pls_golite062009
  • JUN kinase kinase kinase kinase activity
    		•  0.546647574638943 bayes_pls_golite062009
  • insulin binding
    		•  0.546269851452869 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.540818657754841 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.52430033936893 bayes_pls_golite062009
  • activin binding
    		•  0.510364757301021 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.476094076158571 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • 3-phosphoinositide-dependent protein kinase binding
    		•  0.372842462336059 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.371928447183203 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • phosphotyrosine binding
    		•  0.311079584914389 bayes_pls_golite062009
  • channel activity
    		•  0.287189255116606 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.287189255116606 bayes_pls_golite062009
  • DNA binding
    		•  0.281643350069021 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.261869836686301 bayes_pls_golite062009
  • ion channel activity
    		•  0.241519346930618 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.206747304356052 bayes_pls_golite062009
  • insulin receptor activity
    		•  0.188254408239569 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.169458153875562 bayes_pls_golite062009
  • phosphoprotein binding
    		•  0.16798254471727 bayes_pls_golite062009
  • cytokine receptor binding
    		•  0.16478124520484 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.150740450460731 bayes_pls_golite062009
  • kinase regulator activity
    		•  0.10704587503284 bayes_pls_golite062009
  • JUN kinase kinase kinase activity
    		•  0.0613131034808199 bayes_pls_golite062009
  • transforming growth factor beta receptor activity, type I
    		•  0.0506751594607393 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.0443241110585009 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle