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Protein Overview: gi|7303012, gi|2...

General Information:
Name(s) found: gi|7303012 [NCBI NR]
gi|24653990 [NCBI NR]
gi|24653988 [NCBI NR]
gi|21645324 [NCBI NR]
Description(s) found:
Found 13 descriptions.
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  • gi|7303012|gb|AAF58082.1| ATP citrate lyase, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|24653990|ref|NP_725514.1| ATP citrate lyase, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|24653988|ref|NP_523755.1| ATP citrate lyase, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|21645324|gb|AAM70940.1| ATP citrate lyase, isoform B [Drosophila melanogaster] [NCBI NR]
    • Organism: Drosophila melanogaster
    Length: 1086 amino acids

    Gene Ontology:
    Cellular Component: lipid particle [IDA]
    cytoplasm [ISS]
    Biological Process: cellular carbohydrate metabolic process [IEA]
    acetyl-CoA biosynthetic process [ISS]
    citrate metabolic process [ISS]
    Molecular Function: ATP binding [IEA]
    ATP citrate synthase activity [ISS][NAS]
    succinate-CoA ligase (ADP-forming) activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAKAITEAS GKDILNRHLN THGAGAATCR FSTVNSTTDW SKLAVDHPWL LTTPLVCKPD  60
   61 QLIKRRGKLG LIGVKKNFEQ VKQWIGERLN KDQKIGNAVG KLRNFIIEPF VPHTDAEEMY 120
  121 VCIYSHRAAD TILFYHQGGV DIGDVDAKAV KLDVPVNSSL SLADVKSKLL KEVKDAGTKE 180
  181 RIAKFVSALY TTYVDLYFTY LEINPLVVTA DNLYILDLAA KLDSTADFIC RPKWGEIDYP 240
  241 PPFGRDAYPE EAYIADLDAK SGASLKLTIL NRNGRIWTMV AGGGASVIYS DTICDLGGAS 300
  301 ELANYGEYSG APSEQQTYEY AKTILNLMTS SPKHPDGKVL ITGGGIANFT NVAATFQGII 360
  361 TALREFQPKL VEHNVSIFVR RAGPNYQEGL RKMRDFGSTL GIPLHVFGPE THMTAICGMA 420
  421 LGKRPIPQTA SVEFSTANFL LPGGQQAQAD LKAASDASEA LGSGSADEAD SAGISGAQRN 480
  481 GSSLNRKFFS NTTKAIVWGM QQRAVQRDEP SVVAMVYPFT GDHKQKYYWG HKEILIPVYK 540
  541 KMSDAIHKHK EVDVMVNFAS MRSAYESTLE VLEFPQIRTV AIIAEGIPEN MTRKLIIEAD 600
  601 KKGVAIIGPA TVGGVKPGCF KIGNTGGMLD NILHSKLYRP GSVAYVSRSG GMSNELNNII 660
  661 SKATDGVIEG IAIGGDRYPG STFMDHILRY QADPETKLIV LLGEVGGTEE YDVCAALKDG 720
  721 RITKPLVAWC IGTCASMFTS EVQFGHAGSC ANSDRETATA KNKGLRDAGA YVPDSFDTLG 780
  781 ELIHHVYGEL VKTGRVVPKE EVPPPTVPMD YSWARELGLI RKPASFMTSI CDERGQELIY 840
  841 AGMPISEVLS KDVGIGGVIS LLWFQRCLPS YVCKFFEMCL MVTADHGPAV SGAHNTIVCA 900
  901 RAGKDLVSSV VSGLLTIGDR FGGALDGSAR QFSEAYDTNL HPMEFVNKMR KEGKLILGIG 960
  961 HRVKSINNPD VRVKIIKEFV LENFPACPLL KYALEVEKIT TNKKPNLILN VDGVIATAFV1020
 1021 DMLRNSGSFT SEEAQEYINV GAINSLFVLG RSIGFIGHYM DQKRLKQGLY RHPWDDISYV1080
 1081 IPEQYN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..419] PSI-BLAST 102.0 Succinyl-CoA synthetase, beta-chain, C-terminal domain; Succinyl-CoA synthetase, beta-chain, N-terminal domain
    2 View Details [420..720] PSI-BLAST 93.69897 Succinyl-CoA synthetase, alpha-chain, N-terminal (CoA-binding) domain; Succinyl-CoA synthetase, alpha-chain, C-terminal domain
    3 View Details [721..1086] PSI-BLAST 100.0 Citrate synthase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • succinate-CoA ligase activity
    		•  11.5979130191209 bayes_pls_golite062009
  • CoA-ligase activity
    		•  10.4192804448897 bayes_pls_golite062009
  • acid-thiol ligase activity
    		•  10.243481928473 bayes_pls_golite062009
  • ligase activity, forming carbon-sulfur bonds
    		•  9.48706872092269 bayes_pls_golite062009
  • succinate-CoA ligase (ADP-forming) activity
    		•  9.35325976720833 bayes_pls_golite062009
  • succinate-CoA ligase (GDP-forming) activity
    		•  6.10836030777262 bayes_pls_golite062009
  • ATP citrate synthase activity
    		•  6.07828121800931 bayes_pls_golite062009
  • citrate (pro-3S)-lyase activity
    		•  5.30284195415066 bayes_pls_golite062009
  • CoA carboxylase activity
    		•  4.07446700881636 bayes_pls_golite062009
  • acetyl-CoA carboxylase activity
    		•  3.99316522494514 bayes_pls_golite062009
  • ligase activity, forming carbon-carbon bonds
    		•  3.81289459554571 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  3.35963055171077 bayes_pls_golite062009
  • carbamoyl-phosphate synthase activity
    		•  2.72598634080471 bayes_pls_golite062009
  • carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
    		•  2.64774423341735 bayes_pls_golite062009
  • biotin carboxylase activity
    		•  2.54447190719035 bayes_pls_golite062009
  • ligase activity
    		•  2.30626698552338 bayes_pls_golite062009
  • oxo-acid-lyase activity
    		•  2.241458285404 bayes_pls_golite062009
  • catalytic activity
    		•  1.90735517755117 bayes_pls_golite062009
  • phosphoribosylaminoimidazole carboxylase activity
    		•  1.73669882098773 bayes_pls_golite062009
  • transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
    		•  1.34604636411023 bayes_pls_golite062009
  • phosphoribosylamine-glycine ligase activity
    		•  1.23437256414757 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.10474980073192 bayes_pls_golite062009
  • carbon-nitrogen ligase activity, with glutamine as amido-N-donor
    		•  1.04673851330289 bayes_pls_golite062009
  • nucleotide binding
    		•  0.604878609358233 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.6001056330562 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.585676018122244 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.585256446905581 bayes_pls_golite062009
  • acetyltransferase activity
    		•  0.354495767382723 bayes_pls_golite062009
  • glutathione synthase activity
    		•  0.158287661667506 bayes_pls_golite062009
    2
    Term Confidence Notes
  • succinate-CoA ligase activity
    		•  4.98013776954984 bayes_pls_golite062009
  • CoA-ligase activity
    		•  4.35815624912718 bayes_pls_golite062009
  • acid-thiol ligase activity
    		•  4.2282982893826 bayes_pls_golite062009
  • ligase activity, forming carbon-sulfur bonds
    		•  3.82878743369312 bayes_pls_golite062009
  • malate dehydrogenase activity
    		•  3.73899222825747 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  3.18548497718796 bayes_pls_golite062009
  • succinate-CoA ligase (ADP-forming) activity
    		•  3.05087440872447 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.56635944108218 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  2.56237767568509 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.3793692436067 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.15364185593759 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.85842298395473 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.74270988861575 bayes_pls_golite062009
  • fatty acid synthase activity
    		•  1.23679054027553 bayes_pls_golite062009
  • methylenetetrahydrofolate dehydrogenase activity
    		•  0.974298363844148 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.9367410227151 bayes_pls_golite062009
  • methenyltetrahydrofolate cyclohydrolase activity
    		•  0.696602339330799 bayes_pls_golite062009
  • 3-oxoacyl-[acyl-carrier-protein] reductase activity
    		•  0.604742541607263 bayes_pls_golite062009
  • DNA binding
    		•  0.525227236870065 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.459537641913493 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.444544079187632 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.444104594263908 bayes_pls_golite062009
  • malic enzyme activity
    		•  0.431922445809582 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  0.418775403210681 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.386364402115347 bayes_pls_golite062009
  • nucleotide binding
    		•  0.327349935545314 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.32207755075663 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.152651308844322 bayes_pls_golite062009
  • malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity
    		•  0.120195861875768 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  0.00644214957417527 bayes_pls_golite062009
    3
    Term Confidence Notes
  • citrate (Si)-synthase activity
    		•  5.74736490002685 bayes_pls_golite062009
  • transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
    		•  5.63245943049967 bayes_pls_golite062009
  • oxo-acid-lyase activity
    		•  3.68894211625793 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  2.88522337475651 bayes_pls_golite062009
  • catalytic activity
    		•  2.51855037019879 bayes_pls_golite062009
  • transferase activity
    		•  2.22659761972612 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.75

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle