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Protein Overview: ltd-PB

General Information:
Name(s) found: ltd-PB / FBpp0088870 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene lightoid is referred to in FlyBase by the symbol Dmel\ltd (CG8024, FBgn0002567). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:5065369..5073866. It has the cytological map location 45B2-45B3. Based on sequence similarity, it is predicted to have molecular function</span>: GTPase activity; GTP binding. There is experimental evidence that it is involved in the biological process</span>: olfactory learning; learning or memory; eye pigment granule organization; ommochrome biosynthetic process. 21 alleles are reported. The phenotypes of these alleles are annotated with: primary pigment cell pigment granule; Malpighian tubule; secondary pigment cell pigment granule; ocellus pigment granule; tertiary pigment cell pigment granule; pigment cell. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 686 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: eye pigment precursor transport [TAS]
    small GTPase mediated signal transduction [IEA]
    ommochrome biosynthetic process [IMP]
    protein transport [IEA]
    olfactory learning [IMP]
    eye pigment granule organization [IMP]
    learning or memory [IMP]
    Molecular Function: GTP binding [ISS]
    GTPase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPNVDEQRGK AATKRAESEQ SEEKGDRQEG DGDPKDESEE ATAKIKGRSR FTAALRSLSK  60
   61 TKTKRERELD KSTDRETRSA EEEAQETPGE LEDVASSIST DSGALGKTKK KSLTRRLLLG 120
  121 GLRKSGKTPK GRPHSLATSD DISVEHLETT PLPSPPGSPT SAGSSTLQIT ISGKKVEPSP 180
  181 AKKSGKSRPK SDTDYLTPAA EERKPRKKTT TTTVTTRDTS SSTRTTKLLV SKKKPQSPER 240
  241 ESPSASPSPL ITTTESTRDT PPRERAPAKP SRVQSASGTG AVRKSQSSSA SSRKLELMQQ 300
  301 QQQRGHRLNA RPLAELANTE PQPSGQQSLD PSTSPPAAED GVSSAESAQT IANPPPVVRF 360
  361 EVGSAVRSPL SAYEAALAAA ASQQPNSNEE LSDSSIRRLS FAQQQLILGD HDSIEGRRET 420
  421 LHYQSVASEY SNQDSGSEDD SEEQADTTEP ENAKPMPAFG DLTMDQEMEP AIMTSTSDKR 480
  481 EHLYKILVIG ELGTGKTSFI KRYVHQFFSQ NYRATIGVDF ALKVLQWDAN TIVRLQLWDI 540
  541 AGQERFGNMT RVYYKEAVGA FIVFDVTRSG TFDCVSKWKE DLDSKVQLPD GSPIPCILLA 600
  601 NKCDQEKQGI ITQPEKMDEY VRENGFAGWF ETSAKENINI DEAARALVNK ILINDKLISA 660
  661 DLADGDKFNL SAADATGSDA KNKCSC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..133] MSA 1.152996 View MSA. No confident structure predictions are available.
    2 View Details [134..298] MSA 6.164987 View MSA. No confident structure predictions are available.
    3 View Details [299..469] deduced N/A No confident structure predictions are available.
    4 View Details [470..686] PSI-BLAST 65.0 Structure of doubly prenylated Ypt1:GDI complex

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • GTPase activity
    		•  4.52394549632777 bayes_pls_golite062009
  • hydrolase activity
    		•  3.63069754092699 bayes_pls_golite062009
  • microtubule motor activity
    		•  3.4297361345158 bayes_pls_golite062009
  • motor activity
    		•  3.3674051903467 bayes_pls_golite062009
  • actin binding
    		•  3.33639699088484 bayes_pls_golite062009
  • microfilament motor activity
    		•  3.17800963620802 bayes_pls_golite062009
  • signal recognition particle binding
    		•  3.10924684520019 bayes_pls_golite062009
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.95079405147356 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.87427509025394 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.85499564954033 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.85178667290149 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  2.61775212528604 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  2.61467977505707 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  2.57552435627908 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  2.57107347424517 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  2.57054427875021 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  2.50494515048649 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.43862163407966 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.4101693596493 bayes_pls_golite062009
  • ATPase activity
    		•  2.39535714892224 bayes_pls_golite062009
  • actin filament binding
    		•  2.24723363507804 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.21184938313192 bayes_pls_golite062009
  • ribonucleoprotein binding
    		•  2.04103162399905 bayes_pls_golite062009
  • proton-transporting ATPase activity, rotational mechanism
    		•  1.95782378818812 bayes_pls_golite062009
  • DNA binding
    		•  1.94055378599526 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.91091452720653 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  1.89320355239381 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  1.88721318481223 bayes_pls_golite062009
  • GTP binding
    		•  1.87900088157196 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.85943679361938 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.85937484083653 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.8521191028835 bayes_pls_golite062009
  • nucleotide binding
    		•  1.84603132945448 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.83584389083042 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  1.81972511638668 bayes_pls_golite062009
  • kinase activity
    		•  1.80889641165674 bayes_pls_golite062009
    		• 1.75135117904448 bayes_pls_golite062009
  • protein transporter activity
    		•  1.71214667007262 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  1.63949223587737 bayes_pls_golite062009
  • tubulin binding
    		•  1.62788446088451 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.60386625568858 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  1.58897222423517 bayes_pls_golite062009
  • ATP binding
    		•  1.5859264197035 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.56325751172863 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.55520429131224 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.53158018507951 bayes_pls_golite062009
  • microtubule binding
    		•  1.44471873069962 bayes_pls_golite062009
  • antigen binding
    		•  1.43656260286121 bayes_pls_golite062009
  • RNA helicase activity
    		•  1.42791449104435 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  1.39335733374328 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  1.36724390116598 bayes_pls_golite062009
  • apolipoprotein receptor activity
    		•  1.31055516357904 bayes_pls_golite062009
  • syntaxin-13 binding
    		•  1.31055516357904 bayes_pls_golite062009
  • apolipoprotein A-I binding
    		•  1.31055516357904 bayes_pls_golite062009
  • apolipoprotein A-I receptor activity
    		•  1.31055516357904 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • peptidase activity
    		•  1.21715427137954 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.14475274823167 bayes_pls_golite062009
  • protein kinase activity
    		•  1.12864835254143 bayes_pls_golite062009
  • nucleotide kinase activity
    		•  1.10251779925246 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.977237423302079 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.961168578530073 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  0.889480122725603 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  0.876296121718575 bayes_pls_golite062009
  • plus-end-directed microtubule motor activity
    		•  0.773586048423911 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.762584163889896 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.75383985982414 bayes_pls_golite062009
  • transcription activator activity
    		•  0.739301862805678 bayes_pls_golite062009
  • RNA binding
    		•  0.715902454627085 bayes_pls_golite062009
  • transcription factor activity
    		•  0.697256579145077 bayes_pls_golite062009
  • signal transducer activity
    		•  0.683309012097319 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.683309012097319 bayes_pls_golite062009
  • endopeptidase activity
    		•  0.666240085427003 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.661834961742057 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.652333406433794 bayes_pls_golite062009
  • receptor activity
    		•  0.633514002718998 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  0.63002958837536 bayes_pls_golite062009
  • helicase activity
    		•  0.6191010101321 bayes_pls_golite062009
  • sterol transporter activity
    		•  0.57614280790431 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.557919489256916 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.49000746592281 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  0.46552249844591 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  0.444874730945263 bayes_pls_golite062009
  • structural constituent of muscle
    		•  0.411137875876923 bayes_pls_golite062009
  • phosphotransferase activity, phosphate group as acceptor
    		•  0.40217318916177 bayes_pls_golite062009
  • drug transmembrane transporter activity
    		•  0.38711726712063 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.345873656782869 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.325013574811283 bayes_pls_golite062009
  • receptor binding
    		•  0.309955875731734 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.29664013896754 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.29664013896754 bayes_pls_golite062009
  • myosin binding
    		•  0.274885859454447 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.208665086324262 bayes_pls_golite062009
  • translation release factor activity
    		•  0.178286731022211 bayes_pls_golite062009
  • translation termination factor activity
    		•  0.151456842619444 bayes_pls_golite062009
  • nucleobase, nucleoside, nucleotide kinase activity
    		•  0.12351419478929 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.123304946374679 bayes_pls_golite062009
  • serine-type endopeptidase activity
    		•  0.092554747196014 bayes_pls_golite062009
  • G-protein-coupled receptor binding
    		•  0.0436504490626262 bayes_pls_golite062009
  • microtubule plus-end binding
    		•  0.040298400888525 bayes_pls_golite062009
  • serine hydrolase activity
    		•  0.0365009097431372 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  0.0168560258237966 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0111338193708552 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity
    		•  0.00571427458217011 bayes_pls_golite062009
  • macromolecule transmembrane transporter activity
    		•  0.00571427458217011 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle