Protein Overview: cos-PA, FBpp0307854

General Information:
Name(s) found:	FBpp0307854 [FlyBase] cos-PA / FBpp0088087 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|7304235\|gb\|AAF59270.1\| costa [Drosophila melanogaster] [NCBI NR] gi\|201065645\|gb\|ACH92232.1\| FI03725p [Drosophila melanogaster] [NCBI NR] gi\|17137092\|ref\|NP_477092.1\| costa [Drosophila melanogaster] [NCBI NR] gi\|160017392\|sp\|O16844.2\|COS_DROME RecName: Full=Kinesin-like protein costa; AltName: Full=Kinesin-like protein costal2 [NCBI NR] Kinesin-like protein costa OS=Drosophila melanogaster GN=cos PE=1 SV=2 [Swiss-Prot] Kinesin-like protein costal2 OS=Drosophila melanogaster GN=cos PE=1 SV=2 [Swiss-Prot] type=protein; loc=2R:complement(3270702..3272524,3272588..3273006,3273063..3273774,3273833..3274484); ID=FBpp0307854; name=cos-PB; parent=FBgn0000352,FBtr0336916; dbxref=REFSEQ:NP_001260765,GB_protein:AGB93298,FlyBase:FBpp0307854,FlyBase_Annotation_IDs:CG1708-PB; MD5=26345ae70136846b534d55aba69867ed; length=1201; release=r5.56; species=Dmel; [FlyBase] The gene costa is referred to in FlyBase by the symbol Dmel\cos (CG1708, FBgn0000352). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3269669..3274617. It has the cytological map location 43B1-43B2. There is experimental evidence that it has the molecular function</span>: smoothened binding; microtubule binding; protein binding; protein kinase binding; transcription factor binding. There is experimental evidence that it is involved in the biological process</span>: smoothened signaling pathway; regulation of protein stability; negative regulation of transcription factor activity; imaginal disc-derived wing morphogenesis; cytoplasmic sequestering of transcription factor; negative regulation of transcription factor import into nucleus; positive regulation of hh target transcription factor activity. 88 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: adult segment; organ system; adult mesothoracic segment; thoracic segment; imaginal precursor; adult; dorsal thoracic disc; abdominal segment 10; vulva; epiproct. It has one annotated transcript and one annotated polypeptide. [FlyBase] >CG1708-PA translation from_gene[CG1708 cos FBgn0000352] seq_release:3 mol_weight=133149 cds_boundaries:(2R:2,444,101..2,447,880[-]) aa_length:1201 transcript_info:[CG1708-RA seq_release:3] gene_info:[gene symbol:cos FBgn0000352 gene_boundaries:(2R:2,4 [hmr_yeast5_DM3-1_pombe.fasta] (Q9V4K0) COS protein [DrosMelano7227.FASTAC.txt] (AE003841) cos gene product [Drosophila melanogaster] [yeastflysequest.fasta] CG1708-PA [Drosophila melanogaster]gi\|17137092\|ref\|NP_477092.1\| CG1708-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] type=protein; loc=2R:complement(3270702..3272524,3272588..3273006,3273063..3273774,3273833..3274484); ID=FBpp0088087; name=cos-PA; parent=FBgn0000352,FBtr0089015; dbxref=FlyBase:FBpp0088087,FlyBase_Annotation_IDs:CG1708-PA,GB_protein:AAF59270.1,REFSEQ:NP_ [fly-100309-contam.fasta] costa CG1708-PA [Drosophila melanogaster] [nr-271106-contam.fasta] CG1708-PA [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=2R:complement(3270702..3272524,3272588..3273006,3273063..3273774,3273833..3274484); ID=FBpp0088087; name=cos-PA; parent=FBgn0000352,FBtr0089015; dbxref=FlyBase:FBpp0088087,FlyBase_Annotation_IDs:CG1708-PA,GB_protein:AAF59270.1,REFSEQ:NP_477092,GB_protein:AAF59270; MD5=26345ae70136846b534d55aba69867ed; length=1201; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2R:complement(3270702..3272524,3272588..3273006,3273063..3273774,3273833..3274484); ID=FBpp0088087; name=cos-PA; parent=FBgn0000352,FBtr0089015; dbxref=FlyBase:FBpp0088087,FlyBase_Annotation_IDs:CG1708-PA,GB_protein:AAF59270.1,REFSEQ:NP_477092,GB_protein:AAF59270; MD5=26345ae70136846b534d55aba69867ed; length=1201; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=2R:complement(3270702..3272524,3272588..3273006,3273063..3273774,3273833..3274484); ID=FBpp0088087; name=cos-PA; parent=FBgn0000352,FBtr0089015; dbxref=FlyBase:FBpp0088087,FlyBase_Annotation_IDs:CG1708-PA,GB_protein:AAF59270.1,REFSEQ:NP_477092,GB_protein:AAF59270,FlyMine:FBpp0088087,modMine:FBpp0088087; MD5=26345ae70136846b534d55aba69867ed; length=1201; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=2R:complement(join(7386328..7386979,7385558..7386269,7385083..7385501,7383197..7385019)); ID=FBpp0088087; name=cos-PA; parent=FBgn0000352,FBtr0089015; dbxref=FlyBase:FBpp0088087,FlyBase_Annotation_IDs:CG1708-PA,GB_protein:AAF59270.1,REFSEQ:NP_477092,GB_protein:AAF59270,FlyMine:FBpp0088087,modMine:FBpp0088087; MD5=26345ae70136846b534d55aba69867ed; length=1201; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2R:complement(join(7386328..7386979,7385558..7386269,7385083..7385501,7383197..7385019)); ID=FBpp0307854; name=cos-PB; parent=FBgn0000352,FBtr0336916; dbxref=REFSEQ:NP_001260765,GB_protein:AGB93298,FlyBase:FBpp0307854,FlyBase_Annotation_IDs:CG1708-PB; MD5=26345ae70136846b534d55aba69867ed; length=1201; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2R:complement(join(7386328..7386979,7385558..7386269,7385083..7385501,7383197..7385019)); ID=FBpp0088087; name=cos-PA; parent=FBgn0000352,FBtr0089015; dbxref=FlyBase:FBpp0088087,FlyBase_Annotation_IDs:CG1708-PA,GB_protein:AAF59270.1,REFSEQ:NP_477092,GB_protein:AAF59270,FlyMine:FBpp0088087,modMine:FBpp0088087; MD5=26345ae70136846b534d55aba69867ed; length=1201; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] type=protein; loc=2R:complement(join(7386328..7386979,7385558..7386269,7385083..7385501,7383197..7385019)); ID=FBpp0307854; name=cos-PB; parent=FBgn0000352,FBtr0336916; dbxref=REFSEQ:NP_001260765,GB_protein:AGB93298,FlyBase:FBpp0307854,FlyBase_Annotation_IDs:CG1708-PB; MD5=26345ae70136846b534d55aba69867ed; length=1201; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] Isoform of O16844, Kinesin-like protein OS=Drosophila melanogaster GN=cos PE=3 SV=1 [DROME.fasta.20160308] FBpp0088087 type=protein; loc=2R:complement(join(7386328..7386979,7385558..7386269,7385083..7385501,7383197..7385019)); ID=FBpp0088087; name=cos-PA; parent=FBgn0000352,FBtr0089015; dbxref=FlyBase:FBpp0088087,FlyBase_Annotation_IDs:CG1708-PA,GB_protein:AAF59270.1,REFSEQ:NP_477092,GB_protein:AAF59270,FlyMine:FBpp0088087,modMine:FBpp0088087; MD5=26345ae70136846b534d55aba69867ed; length=1201; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] FBpp0307854 type=protein; loc=2R:complement(join(7386328..7386979,7385558..7386269,7385083..7385501,7383197..7385019)); ID=FBpp0307854; name=cos-PB; parent=FBgn0000352,FBtr0336916; dbxref=REFSEQ:NP_001260765,GB_protein:AGB93298,FlyBase:FBpp0307854,FlyBase_Annotation_IDs:CG1708-PB; MD5=26345ae70136846b534d55aba69867ed; length=1201; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=2R:complement(join(7386328..7386979,7385558..7386269,7385083..7385501,7383197..7385019)); ID=FBpp0088087; name=cos-PA; parent=FBgn0000352,FBtr0089015; dbxref=FlyBase:FBpp0088087,FlyBase_Annotation_IDs:CG1708-PA,GB_protein:AAF59270.1,REFSEQ:NP_477092,GB_protein:AAF59270,UniProt/Swiss-Prot:O16844,FlyMine:FBpp0088087,modMine:FBpp0088087; MD5=26345ae70136846b534d55aba69867ed; length=1201; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta] type=protein; loc=2R:complement(join(7386328..7386979,7385558..7386269,7385083..7385501,7383197..7385019)); ID=FBpp0307854; name=cos-PB; parent=FBgn0000352,FBtr0336916; dbxref=REFSEQ:NP_001260765,GB_protein:AGB93298,FlyBase:FBpp0307854,FlyBase_Annotation_IDs:CG1708-PB,UniProt/Swiss-Prot:O16844; MD5=26345ae70136846b534d55aba69867ed; length=1201; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	1201 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA][TAS] vesicle membrane [IDA] kinesin complex [ISS] Hedgehog signaling complex [IPI] microtubule associated complex [IPI] plasma membrane [IDA]
Biological Process:	regulation of protein stability [IDA] ovarian follicle cell development [TAS] regulation of proteolysis [NAS] positive regulation of smoothened signaling pathway [TAS] imaginal disc-derived wing morphogenesis [IMP] smoothened signaling pathway [IMP][IPI][TAS] negative regulation of transcription factor import into nucleus [IMP] negative regulation of transcription factor activity [IMP] cytoplasmic sequestering of transcription factor [IMP] microtubule-based movement [IEA][ISS] positive regulation of hh target transcription factor activity [IMP] negative regulation of smoothened signaling pathway [TAS]
Molecular Function:	protein kinase binding [IPI] ATP binding [IEA] microtubule motor activity [IEA][ISS] protein binding [IPI] smoothened binding [IPI] transcription factor binding [IPI] microtubule binding [IDA] motor activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEIPIQVAVR IFPHRELKDL LRSFGPTEPK KDAQAVDEGA DSKDSEAQVP AAEKDNPSIS  60
   61 ETDPNGNAEQ DSAADSKTIP DANGNDSGQK DYPDSAYCVQ AIPISASALG LPSALPGGDP 120
  121 MDSIAAGLIQ VGPHTVPVTH ALPSSSSQEQ VYHQTVFPLI TLFLEGFDAS VVTYGQRGQG 180
  181 KSYTLYGNVQ DPTLTDSTEG VVQLCVRDIF SHISLHPERT YAINVGFVEI CGGDVCDLLG 240
  241 MGNIHCTNVD AVFHWLQVGL SARQSLPAHT LFTLTLEQQW VSKEGLLQHR LSTASFSDLC 300
  301 GTERCGDQPP GRPLDAGLCM LEQVISTLTD PGLMYGVNGN IPYGQTTLTT LLKDSFGGRA 360
  361 QTLVILCVSP LEEHLPETLG NLQFAFKVQC VRNFVIMNTY SDDNTMIVQP AEPVPESNSS 420
  421 AGPLSQAGPG DNFGLQFAAS QWSKLVTNAE GLFSKLIDSK LITEVEKEQI EEWLFLKQEC 480
  481 EECLSSTEAM RQQKQLVPIL EAEEPEDVNS EAANSESPNS DNENDTDNES HRPDLDDKIE 540
  541 SLMEEFRDKT DALILEKHAE YLSKHPKAVM QSQDREIEAQ PPEENGDDRK VSIGSRRRSV 600
  601 QPGASLSTAE LAMLNRVASQ QPPPPIDPES VVDPLESSSG EGIRQAALAA AAATAPIEQL 660
  661 QKKLRKLVAE IEGKQRQLRE IEETIQVKQN IIAELVKNSD TRSHAKQRFH KKRAKLEAEC 720
  721 DKAKKQLGKA LVQGRDQSEI ERWTTIIGHL ERRLEDLSSM KHIAGESGQK VKKLQQSVGE 780
  781 SRKQADDLQK KLRKECKLRC QMEAELAKLR ESRETGKELV KAQGSPEQQG RQLKAVQARI 840
  841 THLNHILREK SDNLEEQPGP EQQETLRHEI RNLRGTRDLL LEERCHLDRK LKRDKVLTQK 900
  901 EERKLLECDE AIEAIDAAIE FKNEMITGHR SIDTSDRIQR EKGEQMLMAR LNRLSTEEMR 960
  961 TLLYKYFTKV IDLRDSSRKL ELQLVQLERE RDAWEWKERV LSNAVRQARL EGERNAVLLQ1020
 1021 RQHEMKLTLM LRHMAEETSA SSASYGERAL APACVAPPVQ ASSDFDYDHF YKGGGNPSKA1080
 1081 LIKAPKPMPT GSALDKYKDK EQRSGRNIFA KFHVLTRYAS AAAAGSSGST AEESTALIES1140
 1141 TTTATATTTS TTTTGAVGKV KDKALVSFRP EQLKRLMPAP TATKVTRQKN KIIIQDASRR1200
 1201 N

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..90]	deduced	N/A	No confident structure predictions are available.
2	View Details	[91..408]	PSI-BLAST	87.30103	Kinesin
3	View Details	[409..507]	deduced	N/A	No confident structure predictions are available.
4	View Details	[508..1201]	PSI-BLAST	14.522879	Heavy meromyosin subfragment

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Protein Overview: cos-PA, FBpp0307854

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: