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Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule. Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. Any process that modulates the frequency, rate or extent of transcription regulator activity, any molecular function that plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. Any process that decreases the frequency, rate or extent of transcription regulator activity, any molecular function that plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor. Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process by which a gene product interacts selectively with DNA (deoxyribonucleic acid). Any process that stops, prevents or reduces the frequency, rate or extent of the activity of the transcription factor CREB. Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. Any process that stops, prevents or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB. Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA. Any process that stops, prevents or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process by which a gene product interacts selectively with DNA (deoxyribonucleic acid).

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of transcription factor activity
Acc: GO:0043433
Aspect: Biological Process
Desc: Any process that stops, prevents or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
Synonyms:
  • down-regulation of transcription factor activity
  • downregulation of transcription factor activity
  • inhibition of transcription factor activity
  • down regulation of transcription factor activity
Proteins in PDR annotated with:
   This term: 54 [Search]
   Term or descendants: 83 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0043433 - negative regulation of transcription factor activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle