Protein Overview: cos-PA, FBpp0307854

General Information:
Name(s) found:	FBpp0307854 [FlyBase] cos-PA / FBpp0088087 [FlyBase]
Description(s) found: Found 28 descriptions. SHOW ALL	type=protein; loc=2R:complement(3270702..3272524,3272588..3273006,3273063..3273774,3273833..3274484); ID=FBpp0307854; name=cos-PB; parent=FBgn0000352,FBtr0336916; dbxref=REFSEQ:NP_001260765,GB_protein:AGB93298,FlyBase:FBpp0307854,FlyBase_Annotation_IDs:CG1708-PB; MD5=26345ae70136846b534d55aba69867ed; length=1201; release=r5.56; species=Dmel; [FlyBase] The gene costa is referred to in FlyBase by the symbol Dmel\cos (CG1708, FBgn0000352). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3269669..3274617. It has the cytological map location 43B1-43B2. There is experimental evidence that it has the molecular function</span>: smoothened binding; microtubule binding; protein binding; protein kinase binding; transcription factor binding. There is experimental evidence that it is involved in the biological process</span>: smoothened signaling pathway; regulation of protein stability; negative regulation of transcription factor activity; imaginal disc-derived wing morphogenesis; cytoplasmic sequestering of transcription factor; negative regulation of transcription factor import into nucleus; positive regulation of hh target transcription factor activity. 88 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: adult segment; organ system; adult mesothoracic segment; thoracic segment; imaginal precursor; adult; dorsal thoracic disc; abdominal segment 10; vulva; epiproct. It has one annotated transcript and one annotated polypeptide. [FlyBase]
Organism:	Drosophila melanogaster
Length:	1201 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA][TAS] vesicle membrane [IDA] kinesin complex [ISS] Hedgehog signaling complex [IPI] microtubule associated complex [IPI] plasma membrane [IDA]
Biological Process:	regulation of protein stability [IDA] ovarian follicle cell development [TAS] regulation of proteolysis [NAS] positive regulation of smoothened signaling pathway [TAS] imaginal disc-derived wing morphogenesis [IMP] smoothened signaling pathway [IMP][IPI][TAS] negative regulation of transcription factor import into nucleus [IMP] negative regulation of transcription factor activity [IMP] cytoplasmic sequestering of transcription factor [IMP] microtubule-based movement [IEA][ISS] positive regulation of hh target transcription factor activity [IMP] negative regulation of smoothened signaling pathway [TAS]
Molecular Function:	protein kinase binding [IPI] ATP binding [IEA] microtubule motor activity [IEA][ISS] protein binding [IPI] smoothened binding [IPI] transcription factor binding [IPI] microtubule binding [IDA] motor activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEIPIQVAVR IFPHRELKDL LRSFGPTEPK KDAQAVDEGA DSKDSEAQVP AAEKDNPSIS  60
   61 ETDPNGNAEQ DSAADSKTIP DANGNDSGQK DYPDSAYCVQ AIPISASALG LPSALPGGDP 120
  121 MDSIAAGLIQ VGPHTVPVTH ALPSSSSQEQ VYHQTVFPLI TLFLEGFDAS VVTYGQRGQG 180
  181 KSYTLYGNVQ DPTLTDSTEG VVQLCVRDIF SHISLHPERT YAINVGFVEI CGGDVCDLLG 240
  241 MGNIHCTNVD AVFHWLQVGL SARQSLPAHT LFTLTLEQQW VSKEGLLQHR LSTASFSDLC 300
  301 GTERCGDQPP GRPLDAGLCM LEQVISTLTD PGLMYGVNGN IPYGQTTLTT LLKDSFGGRA 360
  361 QTLVILCVSP LEEHLPETLG NLQFAFKVQC VRNFVIMNTY SDDNTMIVQP AEPVPESNSS 420
  421 AGPLSQAGPG DNFGLQFAAS QWSKLVTNAE GLFSKLIDSK LITEVEKEQI EEWLFLKQEC 480
  481 EECLSSTEAM RQQKQLVPIL EAEEPEDVNS EAANSESPNS DNENDTDNES HRPDLDDKIE 540
  541 SLMEEFRDKT DALILEKHAE YLSKHPKAVM QSQDREIEAQ PPEENGDDRK VSIGSRRRSV 600
  601 QPGASLSTAE LAMLNRVASQ QPPPPIDPES VVDPLESSSG EGIRQAALAA AAATAPIEQL 660
  661 QKKLRKLVAE IEGKQRQLRE IEETIQVKQN IIAELVKNSD TRSHAKQRFH KKRAKLEAEC 720
  721 DKAKKQLGKA LVQGRDQSEI ERWTTIIGHL ERRLEDLSSM KHIAGESGQK VKKLQQSVGE 780
  781 SRKQADDLQK KLRKECKLRC QMEAELAKLR ESRETGKELV KAQGSPEQQG RQLKAVQARI 840
  841 THLNHILREK SDNLEEQPGP EQQETLRHEI RNLRGTRDLL LEERCHLDRK LKRDKVLTQK 900
  901 EERKLLECDE AIEAIDAAIE FKNEMITGHR SIDTSDRIQR EKGEQMLMAR LNRLSTEEMR 960
  961 TLLYKYFTKV IDLRDSSRKL ELQLVQLERE RDAWEWKERV LSNAVRQARL EGERNAVLLQ1020
 1021 RQHEMKLTLM LRHMAEETSA SSASYGERAL APACVAPPVQ ASSDFDYDHF YKGGGNPSKA1080
 1081 LIKAPKPMPT GSALDKYKDK EQRSGRNIFA KFHVLTRYAS AAAAGSSGST AEESTALIES1140
 1141 TTTATATTTS TTTTGAVGKV KDKALVSFRP EQLKRLMPAP TATKVTRQKN KIIIQDASRR1200
 1201 N

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
microtubule motor activity	7.68336791348661	bayes_pls_golite062009
plus-end-directed microtubule motor activity	4.97507344344589	bayes_pls_golite062009
motor activity	4.04927796049806	bayes_pls_golite062009
transporter activity	3.10463051760206	bayes_pls_golite062009
transmembrane transporter activity	2.95886887664984	bayes_pls_golite062009
nucleoside-triphosphatase activity	2.95079405147356	bayes_pls_golite062009
pyrophosphatase activity	2.87427509025394	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	2.85499564954033	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	2.85178667290149	bayes_pls_golite062009
smoothened binding	2.78675393035288	bayes_pls_golite062009
tubulin binding	2.67743463093593	bayes_pls_golite062009
microtubule binding	2.59155206524122	bayes_pls_golite062009
hydrolase activity	2.55157966585974	bayes_pls_golite062009
active transmembrane transporter activity	2.50494515048649	bayes_pls_golite062009
primary active transmembrane transporter activity	2.39629638016861	bayes_pls_golite062009
P-P-bond-hydrolysis-driven transmembrane transporter activity	2.39600931083427	bayes_pls_golite062009
ATPase activity	2.39535714892224	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	2.36051733655256	bayes_pls_golite062009
ATPase activity, coupled to movement of substances	2.35906629925754	bayes_pls_golite062009
ATPase activity, coupled to transmembrane movement of substances	2.35679406876731	bayes_pls_golite062009
ATPase activity, coupled	2.24901251684901	bayes_pls_golite062009
binding	2.21604035604783	bayes_pls_golite062009
protein transporter activity	1.71214667007262	bayes_pls_golite062009
substrate-specific transporter activity	1.65609907941094	bayes_pls_golite062009
nucleic acid binding	1.6268310953221	bayes_pls_golite062009
DNA binding	1.52986172845338	bayes_pls_golite062009
transcription regulator activity	1.49328374516529	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.3182108176243	bayes_pls_golite062009
microfilament motor activity	1.28029120876672	bayes_pls_golite062009
protein binding	1.22129154759482	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
cytoskeletal protein binding	0.990232056623698	bayes_pls_golite062009
purine nucleotide binding	0.929901285538132	bayes_pls_golite062009
nucleotide binding	0.922442819194247	bayes_pls_golite062009
purine ribonucleotide binding	0.920987930180051	bayes_pls_golite062009
ribonucleotide binding	0.920926158369519	bayes_pls_golite062009
GTPase activity	0.83849854735032	bayes_pls_golite062009
ion transmembrane transporter activity	0.704934361725919	bayes_pls_golite062009
molecular transducer activity	0.683309012097319	bayes_pls_golite062009
signal transducer activity	0.683309012097319	bayes_pls_golite062009
transmembrane receptor activity	0.661834961742057	bayes_pls_golite062009
receptor activity	0.633514002718998	bayes_pls_golite062009
guanyl nucleotide binding	0.58271536409458	bayes_pls_golite062009
GTP binding	0.5687070753098	bayes_pls_golite062009
guanyl ribonucleotide binding	0.54474544621658	bayes_pls_golite062009
ATP binding	0.41092997612902	bayes_pls_golite062009
adenyl ribonucleotide binding	0.385813421701492	bayes_pls_golite062009
adenyl nucleotide binding	0.377870145186619	bayes_pls_golite062009
actin-dependent ATPase activity	0.36110509588725	bayes_pls_golite062009
transcription factor activity	0.342904707338268	bayes_pls_golite062009
cation transmembrane transporter activity	0.282397764628576	bayes_pls_golite062009
signal recognition particle binding	0.20866768220789	bayes_pls_golite062009
structural constituent of ribosome	0.208665086324262	bayes_pls_golite062009
minus-end-directed microtubule motor activity	0.068779631341469	bayes_pls_golite062009
structural constituent of cytoskeleton	0.028319099023125	bayes_pls_golite062009

No functions predicted.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..90]	deduced	N/A	No confident structure predictions are available.
2	View Details	[91..408]	PSI-BLAST	87.30103	Kinesin
3	View Details	[409..507]	deduced	N/A	No confident structure predictions are available.
4	View Details	[508..1201]	PSI-BLAST	14.522879	Heavy meromyosin subfragment

Protein Overview: cos-PA, FBpp0307854

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: