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Protein Overview: SMAD3_RAT

General Information:
Name(s) found: SMAD3_RAT [Swiss-Prot]
Description(s) found:
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  • gi|6981174|ref|NP_037227.1| SMAD family member 3 [Rattus norvegicus] [NCBI NR]
  • gi|54039606|sp|P84025.1|SMAD3_RAT RecName: Full=Mothers against decapentaplegic homolog 3; Short=Mad3; Short=Mothers against DPP homolog 3; AltName: Full=SMAD 3 [NCBI NR]
  • gi|39962976|gb|AAH64437.1| SMAD family member 3 [Rattus norvegicus] [NCBI NR]
  • gi|1710131|gb|AAC52944.1| mothers against dpp 3 homolog [Rattus norvegicus] [NCBI NR]
  • gi|149041936|gb|EDL95777.1| MAD homolog 3 (Drosophila) [Rattus norvegicus] [NCBI NR]
  • Mothers against decapentaplegic homolog 3 OS=Rattus norvegicus GN=Smad3 PE=1 SV=1 [Swiss-Prot]
  • (P84025) Mothers against decapentaplegic homolog 3 (SMAD 3) (Mothers against DPP homolog 3) (Mad3) [Swiss-Prot]
  • Ensembl_locations(Chr-bp):8-66188434 MAD homolog 3 [hmr_yeast5_DM3-1_pombe.fasta]
  • MAD homolog 3; MAD (mothers against decapentaplegic, Drosophila) homolog 3; MAD (mothers against decapentaplegic Drosophila) homolog 3 [HMR_022704-rand.fasta]
  • MAD, mothers against decapentaplegic homolog 3 [Homo sapiens]gi|6981174|ref|NP_037227.1| MAD homolog 3 [Rattus norvegicus]gi|47523074|ref|NP_999302.1| MAD, mothers against decapentaplegic homolog 3 [Sus scrofa]gi|45219863|gb|AAH66850.1| MAD homolog 3 [ [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Mothers against decapentaplegic homolog 3 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • (NM_013095) MAD homolog 3; MAD (mothers against decapentaplegic, Drosophila) homolog 3 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • MAD homolog 3 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Mothers against decapentaplegic homolog 3 (Mad3) (Mothers against DPP homolog 3) (SMAD 3) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • MAD homolog 3 (Drosophila) [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • mothers against dpp 3 homolog [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • SMAD family member 3 [Rattus norvegicus] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta]
  • Mothers against decapentaplegic homolog 3 (SMAD 3) (Mothers against DPP homolog 3) (Mad3) [nr-271106-contam.fasta]
  • Tax_Id=10116 Gene_Symbol=Smad3 Mothers against decapentaplegic homolog 3 [rat-ipi-250309-contam.fasta]
  • Mothers against decapentaplegic homolog 3 OS=Rattus norvegicus GN=Smad3 [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 425 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IDA]
    transcription factor complex [IMP]
    nuclear inner membrane [UNKNOWN][IEA]
    cytoplasm [UNKNOWN][IDA]
    cytosol [UNKNOWN]
    receptor complex [UNKNOWN][IEA]
    protein complex [IDA]
    intracellular [IEA]
    plasma membrane [UNKNOWN][IEA]
    nucleoplasm [UNKNOWN]
    Biological Process: cell cycle arrest [UNKNOWN][IEA]
    endoderm development [UNKNOWN][IEA]
    transforming growth factor beta receptor signaling pathway [UNKNOWN][IMP]
    immune system development [UNKNOWN][IEA]
    skeletal system development [UNKNOWN][IEA]
    response to hypoxia [UNKNOWN][IEA]
    immune response [UNKNOWN]
    in utero embryonic development [UNKNOWN][IEA]
    induction of apoptosis [UNKNOWN][IEA]
    negative regulation of cell growth [UNKNOWN][IEA]
    positive regulation of transcription, DNA-dependent [UNKNOWN]
    heart looping [UNKNOWN][IEA]
    transdifferentiation [IDA]
    evasion of host defenses by virus [UNKNOWN][IEA]
    mesoderm formation [UNKNOWN][IEA]
    activation of caspase activity [UNKNOWN][IEA]
    regulation of epithelial cell proliferation [UNKNOWN][IEA]
    positive regulation of alkaline phosphatase activity [IDA]
    positive regulation of bone mineralization [IDA]
    SMAD protein complex assembly [UNKNOWN][IPI]
    embryonic pattern specification [UNKNOWN][IEA]
    positive regulation of positive chemotaxis [IDA]
    negative regulation of mitotic cell cycle [UNKNOWN][IEA]
    transport [UNKNOWN][IEA]
    cell-cell junction organization [UNKNOWN][IEA]
    pericardium development [UNKNOWN][IEA]
    activation of pro-apoptotic gene products [IMP]
    positive regulation of focal adhesion assembly [IDA]
    somitogenesis [UNKNOWN][IEA]
    positive regulation of stress fiber assembly [IDA]
    positive regulation of transforming growth factor-beta3 production [IMP]
    regulation of binding [UNKNOWN][IEA]
    release of cytochrome c from mitochondria [IMP]
    regulation of transforming growth factor beta receptor signaling pathway [UNKNOWN][IEA]
    regulation of striated muscle tissue development [UNKNOWN][IEA]
    positive regulation of cell migration [IMP]
    negative regulation of cell proliferation [IDA]
    T cell activation [IEA]
    positive regulation of transcription [UNKNOWN]
    regulation of transforming growth factor-beta2 production [UNKNOWN][IEA]
    positive regulation of transcription factor import into nucleus [UNKNOWN][IEA]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN]
    embryonic foregut morphogenesis [UNKNOWN][IEA]
    negative regulation of osteoblast differentiation [UNKNOWN][IEA]
    negative regulation of transcription from RNA polymerase II promoter [UNKNOWN]
    positive regulation of epithelial to mesenchymal transition [UNKNOWN][IEA]
    paraxial mesoderm morphogenesis [UNKNOWN][IEA]
    apoptotic mitochondrial changes [IMP]
    liver development [UNKNOWN][IEA]
    positive regulation of gene-specific transcription from RNA polymerase II promoter [IDA][IMP]
    lens fiber cell differentiation [UNKNOWN][IEA]
    negative regulation of gene-specific transcription from RNA polymerase II promoter [IDA]
    regulation of immune response [IEA]
    regulation of transcription, DNA-dependent [IEA]
    embryonic cranial skeleton morphogenesis [UNKNOWN][IEA]
    osteoblast development [UNKNOWN][IEA]
    developmental growth [UNKNOWN][IEA]
    gastrulation [UNKNOWN][IEA]
    thyroid gland development [UNKNOWN][IEA]
    ureteric bud development [UNKNOWN][IEA]
    negative regulation of apoptosis [IDA]
    positive regulation of interleukin-1 beta production [IMP]
    Molecular Function: protein kinase binding [UNKNOWN][IEA]
    protein homodimerization activity [UNKNOWN][IEA]
    transforming growth factor beta receptor binding [UNKNOWN][IEA]
    double-stranded DNA binding [UNKNOWN][IEA]
    sequence-specific DNA binding [UNKNOWN][IDA]
    transcription factor binding [UNKNOWN][IDA][IPI]
    DNA binding [IDA]
    transcription factor activity [UNKNOWN][IDA]
    protein binding [UNKNOWN][IPI]
    ubiquitin protein ligase binding [UNKNOWN][IEA]
    collagen binding [UNKNOWN][IEA]
    SMAD binding [IPI]
    transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity [UNKNOWN][IEA]
    ligand-regulated transcription factor activity [IMP]
    R-SMAD binding [UNKNOWN][IEA]
    co-SMAD binding [UNKNOWN][IEA]
    promoter binding [UNKNOWN][IEA]
    transcription activator activity [UNKNOWN][IEA]
    specific transcriptional repressor activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSILPFTPP IVKRLLGWKK GEQNGQEEKW CEKAVKSLVK KLKKTGQLDE LEKAITTQNV  60
   61 NTKCITIPRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH HELRAMELCE FAFNMKKDEV 120
  121 CVNPYHYQRV ETPVLPPVLV PRHTEIPAEF PPLDDYSHSI PENTNFPAGI EPQSNIPETP 180
  181 PPGYLSEDGE TSDHQMNHSM DAGSPNLSPN PMSPAHNNLD LQPVTYCEPA FWCSISYYEL 240
  241 NQRVGETFHA SQPSMTVDGF TDPSNSERFC LGLLSNVNRN AAVELTRRHI GRGVRLYYIG 300
  301 GEVFAECLSD SAIFVQSPNC NQRYGWHPAT VCKIPPGCNL KIFNNQEFAA LLAQSVNQGF 360
  361 EAVYQLTRMC TIRMSFVKGW GAEYRRQTVT STPCWIELHL NGPLQWLDKV LTQMGSPSIR 420
  421 CSSVS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..145] PSI-BLAST 62.522879 Crystal structure of Smad3-MH1 bound to DNA at 2.4 A resolution
    2 View Details [146..425] PSI-BLAST 103.0 Smad2 MH2 domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • SMAD binding
    		•  9.3718253521769 bayes_pls_golite062009
  • R-SMAD binding
    		•  9.05113862383896 bayes_pls_golite062009
  • transforming growth factor beta receptor, cytoplasmic mediator activity
    		•  5.17758651944685 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase signaling protein activity
    		•  4.95270065635384 bayes_pls_golite062009
  • co-SMAD binding
    		•  4.57538059815089 bayes_pls_golite062009
  • transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
    		•  4.49077041445033 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  4.40792626415753 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  4.11302084276027 bayes_pls_golite062009
  • binding
    		•  3.6561903894619 bayes_pls_golite062009
  • transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
    		•  3.61855740138956 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.49687772656017 bayes_pls_golite062009
  • protein binding
    		•  3.44553762357492 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.3543221973342 bayes_pls_golite062009
  • signal transducer activity
    		•  3.3543221973342 bayes_pls_golite062009
  • DNA binding
    		•  3.30334070294767 bayes_pls_golite062009
  • type I transforming growth factor beta receptor binding
    		•  3.25693690222359 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.21526555447097 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  3.11943104361829 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  3.08220855629618 bayes_pls_golite062009
  • transcription activator activity
    		•  2.94935902482394 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  2.94401714632865 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.88406197124131 bayes_pls_golite062009
  • activin binding
    		•  2.85561990563659 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.61166537801555 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  2.57320437127906 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  2.57320437127906 bayes_pls_golite062009
  • phosphatase activity
    		•  2.46582579847871 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  2.41505949322677 bayes_pls_golite062009
  • promoter binding
    		•  2.30493918456602 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.1294440466744 bayes_pls_golite062009
  • transcription factor activity
    		•  2.08449567315174 bayes_pls_golite062009
  • collagen binding
    		•  1.9825610927799 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.88096476099716 bayes_pls_golite062009
  • kinase activity
    		•  1.82476774968305 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.74929788315626 bayes_pls_golite062009
  • protein kinase activity
    		•  1.73373132141588 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.66058356077795 bayes_pls_golite062009
  • transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
    		•  1.61493700485683 bayes_pls_golite062009
  • I-SMAD binding
    		•  1.6033600450778 bayes_pls_golite062009
  • chromatin binding
    		•  1.44267609273288 bayes_pls_golite062009
  • small conjugating protein binding
    		•  1.3559369584113 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.32552524966562 bayes_pls_golite062009
  • transferase activity
    		•  1.29860325699399 bayes_pls_golite062009
  • ubiquitin binding
    		•  1.28191134965346 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.21988722144674 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  1.1868962075754 bayes_pls_golite062009
  • receptor binding
    		•  1.1261895404991 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  1.10293974101617 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  1.02636679142543 bayes_pls_golite062009
  • histone binding
    		•  1.01074250987871 bayes_pls_golite062009
  • transcription factor binding
    		•  0.95553719139833 bayes_pls_golite062009
  • ubiquitin protein ligase binding
    		•  0.85140744915405 bayes_pls_golite062009
  • hydrolase activity
    		•  0.711787881321496 bayes_pls_golite062009
  • RNA binding
    		•  0.403713641965787 bayes_pls_golite062009
  • enzyme binding
    		•  0.34998623523914 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.33340925100096 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.15013949452504 bayes_pls_golite062009
  • identical protein binding
    		•  0.0513801649373811 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.0339057097360133 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle