| Protein: | SMAD3_RAT |
| Organism: | Rattus norvegicus |
| Length: | 425 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SMAD3_RAT.
| Description | E-value | Query Range |
Subject Range |
|
|
0.0 | [1..425] | [1..425] |
|
|
0.0 | [1..425] | [1..425] |
|
|
0.0 | [1..424] | [1..424] |
|
|
0.0 | [1..425] | [1..425] |
|
|
0.0 | [1..425] | [286..710] |
|
|
0.0 | [1..425] | [1..435] |
|
|
0.0 | [1..425] | [1..426] |
|
|
0.0 | [3..425] | [2..425] |
|
Region A: Residues: [1-145] |
1 11 21 31 41 51
| | | | | |
1 MSSILPFTPP IVKRLLGWKK GEQNGQEEKW CEKAVKSLVK KLKKTGQLDE LEKAITTQNV 60
61 NTKCITIPRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH HELRAMELCE FAFNMKKDEV 120
121 CVNPYHYQRV ETPVLPPVLV PRHTE
|
| Detection Method: |  |
| Confidence: | 62.522879 |
| Match: | 1ozjA |
| Description: | Crystal structure of Smad3-MH1 bound to DNA at 2.4 A resolution |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [146-425] |
1 11 21 31 41 51
| | | | | |
1 IPAEFPPLDD YSHSIPENTN FPAGIEPQSN IPETPPPGYL SEDGETSDHQ MNHSMDAGSP 60
61 NLSPNPMSPA HNNLDLQPVT YCEPAFWCSI SYYELNQRVG ETFHASQPSM TVDGFTDPSN 120
121 SERFCLGLLS NVNRNAAVEL TRRHIGRGVR LYYIGGEVFA ECLSDSAIFV QSPNCNQRYG 180
181 WHPATVCKIP PGCNLKIFNN QEFAALLAQS VNQGFEAVYQ LTRMCTIRMS FVKGWGAEYR 240
241 RQTVTSTPCW IELHLNGPLQ WLDKVLTQMG SPSIRCSSVS
|
| Detection Method: | |
| Confidence: | 103.0 |
| Match: | 1khxA |
| Description: | Smad2 MH2 domain |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| SMAD binding | 9.3718253521769 | bayes_pls_golite062009 |
| R-SMAD binding | 9.05113862383896 | bayes_pls_golite062009 |
| transforming growth factor beta receptor, cytoplasmic mediator activity | 5.17758651944685 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase signaling protein activity | 4.95270065635384 | bayes_pls_golite062009 |
| co-SMAD binding | 4.57538059815089 | bayes_pls_golite062009 |
| transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity | 4.49077041445033 | bayes_pls_golite062009 |
| ubiquitin-protein ligase activity | 4.40792626415753 | bayes_pls_golite062009 |
| small conjugating protein ligase activity | 4.11302084276027 | bayes_pls_golite062009 |
| binding | 3.6561903894619 | bayes_pls_golite062009 |
| transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity | 3.61855740138956 | bayes_pls_golite062009 |
| transcription regulator activity | 3.49687772656017 | bayes_pls_golite062009 |
| protein binding | 3.44553762357492 | bayes_pls_golite062009 |
| molecular transducer activity | 3.3543221973342 | bayes_pls_golite062009 |
| signal transducer activity | 3.3543221973342 | bayes_pls_golite062009 |
| DNA binding | 3.30334070294767 | bayes_pls_golite062009 |
| type I transforming growth factor beta receptor binding | 3.25693690222359 | bayes_pls_golite062009 |
| nucleic acid binding | 3.21526555447097 | bayes_pls_golite062009 |
| acid-amino acid ligase activity | 3.11943104361829 | bayes_pls_golite062009 |
| receptor signaling protein activity | 3.08220855629618 | bayes_pls_golite062009 |
| transcription activator activity | 2.94935902482394 | bayes_pls_golite062009 |
| receptor serine/threonine kinase binding | 2.94401714632865 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 2.88406197124131 | bayes_pls_golite062009 |
| activin binding | 2.85561990563659 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 2.61166537801555 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase binding | 2.57320437127906 | bayes_pls_golite062009 |
| transforming growth factor beta receptor binding | 2.57320437127906 | bayes_pls_golite062009 |
| phosphatase activity | 2.46582579847871 | bayes_pls_golite062009 |
| phosphoric ester hydrolase activity | 2.41505949322677 | bayes_pls_golite062009 |
| promoter binding | 2.30493918456602 | bayes_pls_golite062009 |
| hydrolase activity, acting on ester bonds | 2.1294440466744 | bayes_pls_golite062009 |
| transcription factor activity | 2.08449567315174 | bayes_pls_golite062009 |
| collagen binding | 1.9825610927799 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.88096476099716 | bayes_pls_golite062009 |
| kinase activity | 1.82476774968305 | bayes_pls_golite062009 |
| transcription repressor activity | 1.74929788315626 | bayes_pls_golite062009 |
| protein kinase activity | 1.73373132141588 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.66058356077795 | bayes_pls_golite062009 |
| transforming growth factor beta receptor, common-partner cytoplasmic mediator activity | 1.61493700485683 | bayes_pls_golite062009 |
| I-SMAD binding | 1.6033600450778 | bayes_pls_golite062009 |
| chromatin binding | 1.44267609273288 | bayes_pls_golite062009 |
| small conjugating protein binding | 1.3559369584113 | bayes_pls_golite062009 |
| structure-specific DNA binding | 1.32552524966562 | bayes_pls_golite062009 |
| transferase activity | 1.29860325699399 | bayes_pls_golite062009 |
| ubiquitin binding | 1.28191134965346 | bayes_pls_golite062009 |
| double-stranded DNA binding | 1.21988722144674 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 1.1868962075754 | bayes_pls_golite062009 |
| receptor binding | 1.1261895404991 | bayes_pls_golite062009 |
| cell adhesion molecule binding | 1.10293974101617 | bayes_pls_golite062009 |
| ligase activity, forming carbon-nitrogen bonds | 1.02636679142543 | bayes_pls_golite062009 |
| histone binding | 1.01074250987871 | bayes_pls_golite062009 |
| transcription factor binding | 0.95553719139833 | bayes_pls_golite062009 |
| ubiquitin protein ligase binding | 0.85140744915405 | bayes_pls_golite062009 |
| hydrolase activity | 0.711787881321496 | bayes_pls_golite062009 |
| RNA binding | 0.403713641965787 | bayes_pls_golite062009 |
| enzyme binding | 0.34998623523914 | bayes_pls_golite062009 |
| protein dimerization activity | 0.33340925100096 | bayes_pls_golite062009 |
| specific transcriptional repressor activity | 0.15013949452504 | bayes_pls_golite062009 |
| identical protein binding | 0.0513801649373811 | bayes_pls_golite062009 |
| protein homodimerization activity | 0.0339057097360133 | bayes_pls_golite062009 |
