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Protein Overview: SHH_RAT

General Information:
Name(s) found: SHH_RAT [Swiss-Prot]
Description(s) found:
Found 18 descriptions.
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  • Sonic hedgehog protein OS=Rattus norvegicus GN=Shh PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 437 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [UNKNOWN][IEA]
    nucleus [UNKNOWN][IEA]
    extracellular space [UNKNOWN][IDA][ISS]
    membrane raft [UNKNOWN][IDA][ISS]
    endoplasmic reticulum [IDA]
    Golgi apparatus [IDA]
    transport vesicle [IDA]
    extracellular matrix [UNKNOWN][IEA]
    extracellular region [IEA]
    plasma membrane [IEA]
    cell surface [UNKNOWN][ISS]
    Biological Process: embryonic development [UNKNOWN][ISS]
    lung-associated mesenchyme development [UNKNOWN][IEA]
    anterior/posterior pattern formation [UNKNOWN][IEA]
    axon guidance [UNKNOWN][ISS]
    regulation of epithelial cell proliferation involved in prostate gland development [UNKNOWN]
    tongue morphogenesis [IMP]
    positive regulation of penile erection [IMP]
    positive regulation of epithelial cell proliferation involved in prostate gland development [UNKNOWN][IEA]
    branching morphogenesis of a tube [UNKNOWN][ISS]
    skin development [UNKNOWN][IEA]
    prostate epithelial cord elongation [UNKNOWN][IEA]
    dorsal/ventral pattern formation [UNKNOWN][ISS]
    neuroblast proliferation [UNKNOWN][IEP][ISS]
    response to hypoxia [IEP]
    cell death [UNKNOWN][IEA]
    hair follicle development [UNKNOWN]
    positive regulation of skeletal muscle tissue development [UNKNOWN][IEA]
    kidney development [UNKNOWN]
    vasculature development [UNKNOWN]
    heart looping [UNKNOWN][IEA]
    positive regulation of skeletal muscle cell proliferation [UNKNOWN][IEA]
    cell fate specification [UNKNOWN][ISS]
    positive regulation of oligodendrocyte progenitor proliferation [IDA]
    male genitalia morphogenesis [IMP]
    positive regulation of protein import into nucleus [UNKNOWN][IEA]
    cell-cell signaling [UNKNOWN][ISS]
    positive regulation of granule cell precursor proliferation [UNKNOWN][IEA]
    pattern specification process [UNKNOWN][ISS]
    anatomical structure formation involved in morphogenesis [UNKNOWN]
    organ formation [UNKNOWN]
    primary prostatic bud elongation [UNKNOWN][IEA]
    [NOT]prostatic bud formation [UNKNOWN]
    central nervous system development [UNKNOWN][ISS]
    male genitalia development [UNKNOWN][ISS]
    mesenchymal cell proliferation involved in lung development [UNKNOWN][IEA]
    myotube differentiation [UNKNOWN][IEA]
    establishment of cell polarity [UNKNOWN][IEA]
    hair follicle morphogenesis [UNKNOWN][IEA]
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process [UNKNOWN][IEA]
    cell proliferation [UNKNOWN]
    smoothened signaling pathway involved in regulation of granule cell precursor cell proliferation [UNKNOWN][IEA]
    regulation of mesenchymal cell proliferation involved in prostate gland development [UNKNOWN][IEA]
    negative regulation of alpha-beta T cell differentiation [UNKNOWN][IEA]
    salivary gland cavitation [UNKNOWN][IEA]
    mesenchymal smoothened signaling pathway involved in prostate gland development [UNKNOWN][IEA]
    Bergmann glial cell differentiation [UNKNOWN][IEA]
    positive regulation of cell proliferation [UNKNOWN][IDA][ISS]
    palate development [UNKNOWN]
    positive regulation of neuron differentiation [IMP]
    negative regulation of smooth muscle cell differentiation [IEA]
    lung epithelium development [UNKNOWN][IEA]
    blood coagulation [UNKNOWN][IEA]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN]
    epithelial cell proliferation involved in salivary gland morphogenesis [UNKNOWN][IEA]
    lung morphogenesis [UNKNOWN]
    heart development [UNKNOWN][ISS]
    striated muscle cell differentiation [UNKNOWN]
    angiogenesis [UNKNOWN]
    neuron fate commitment [UNKNOWN][ISS]
    camera-type eye development [UNKNOWN][IEA]
    oligodendrocyte differentiation [UNKNOWN]
    digestive tract morphogenesis [UNKNOWN]
    multicellular structure septum development [UNKNOWN][IEA]
    osteoblast development [UNKNOWN][IEA]
    embryonic skeletal system development [UNKNOWN][IEA]
    determination of left/right symmetry [UNKNOWN][IEA]
    ventral spinal cord interneuron specification [IDA]
    androgen metabolic process [UNKNOWN][ISS]
    thyroid gland development [UNKNOWN]
    metanephros development [ISS]
    positive regulation of striated muscle cell differentiation [UNKNOWN][IEA]
    branching involved in ureteric bud morphogenesis [UNKNOWN][ISS]
    positive regulation of smooth muscle cell differentiation [IEA]
    cell fate commitment [UNKNOWN]
    response to organic nitrogen [IEP]
    branching involved in lung morphogenesis [UNKNOWN][IEP]
    branching involved in prostate gland morphogenesis [UNKNOWN]
    epithelial-mesenchymal cell signaling [UNKNOWN]
    inner ear development [UNKNOWN]
    regulation of prostatic bud formation [UNKNOWN][IEA]
    myoblast differentiation [UNKNOWN][IEA]
    positive regulation of photoreceptor cell differentiation [IDA]
    negative regulation of protein catabolic process [UNKNOWN]
    spinal cord dorsal/ventral patterning [UNKNOWN][IDA]
    embryonic digestive tract morphogenesis [UNKNOWN][IEA]
    response to axon injury [IMP]
    embryo sac morphogenesis [UNKNOWN]
    regulation of transcription [UNKNOWN][IEA]
    artery development [UNKNOWN]
    branching involved in salivary gland morphogenesis [UNKNOWN][IEA]
    embryonic digit morphogenesis [UNKNOWN][ISS]
    positive regulation of oligodendrocyte differentiation [UNKNOWN][IEA]
    bud outgrowth involved in lung branching [UNKNOWN][IEA]
    midbrain development [UNKNOWN][ISS]
    response to retinoic acid [IEP]
    forebrain development [UNKNOWN][ISS]
    hindbrain development [UNKNOWN][ISS]
    apoptosis [UNKNOWN]
    embryonic forelimb morphogenesis [UNKNOWN][IEA]
    embryonic hindlimb morphogenesis [UNKNOWN][IEA]
    dorsal/ventral neural tube patterning [UNKNOWN][IEA]
    positive regulation of neuroblast proliferation [UNKNOWN][IDA]
    smoothened signaling pathway [UNKNOWN][ISS][TAS]
    trachea development [UNKNOWN]
    positive regulation of mesenchymal cell proliferation [UNKNOWN][IEA]
    embryonic organ development [UNKNOWN][IEA]
    trachea morphogenesis [UNKNOWN][IEA]
    endocytosis [UNKNOWN][IEA]
    gut mesoderm development [IDA]
    positive regulation of hh target transcription factor activity [UNKNOWN][IEA]
    regulation of epithelial cell differentiation [IEP]
    neural crest cell migration [UNKNOWN][ISS]
    positive regulation of gene expression [UNKNOWN][IEA]
    striated muscle tissue development [UNKNOWN]
    regulation of gene expression [UNKNOWN]
    response to estradiol stimulus [IEP]
    mesenchymal cell proliferation [UNKNOWN]
    prostate gland development [UNKNOWN][IEP][ISS]
    negative regulation of cell migration [UNKNOWN][ISS]
    oligodendrocyte development [UNKNOWN][IEA]
    lung lobe morphogenesis [UNKNOWN][IEA]
    telencephalon regionalization [UNKNOWN][IMP]
    anatomical structure development [UNKNOWN]
    odontogenesis of dentine-containing tooth [UNKNOWN][IEA]
    vasculogenesis [UNKNOWN][ISS]
    ectoderm development [UNKNOWN][IEA]
    intermediate filament organization [UNKNOWN][IEA]
    embryonic foregut morphogenesis [UNKNOWN][IEA]
    formation of anatomical boundary [UNKNOWN][IEA]
    embryonic limb morphogenesis [UNKNOWN][ISS]
    response to ethanol [IDA]
    neural tube formation [IMP]
    patterning of blood vessels [UNKNOWN][ISS]
    negative regulation of cell differentiation [UNKNOWN][ISS]
    positive regulation of gene-specific transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    respiratory tube development [UNKNOWN]
    negative regulation of gene-specific transcription from RNA polymerase II promoter [UNKNOWN][IEA]
    lung development [UNKNOWN][ISS]
    pancreas development [UNKNOWN][IEA]
    intein-mediated protein splicing [IEA]
    limb development [UNKNOWN][IEA]
    limb bud formation [UNKNOWN][IEA]
    regulation of proteolysis [UNKNOWN][ISS]
    left lung development [UNKNOWN][IEA]
    positive regulation of cell differentiation [UNKNOWN]
    hindgut morphogenesis [UNKNOWN][IEA]
    cell development [UNKNOWN][ISS]
    developmental growth [UNKNOWN][IEA]
    regulation of cell proliferation [UNKNOWN][IDA][ISS]
    right lung development [UNKNOWN][IEA]
    epithelial-mesenchymal signaling involved in prostate gland development [UNKNOWN]
    embryonic morphogenesis [UNKNOWN]
    negative regulation of T cell proliferation [UNKNOWN][IEA]
    negative regulation of apoptosis [IMP]
    Molecular Function: zinc ion binding [UNKNOWN][ISS]
    protein binding [UNKNOWN][IPI]
    glycosaminoglycan binding [UNKNOWN][IEA]
    calcium ion binding [UNKNOWN][ISS]
    glycoprotein binding [UNKNOWN][IEA]
    peptidase activity [IEA]
    transcription activator activity [IEA]
    laminin-1 binding [UNKNOWN][ISS]
    signal transducer activity [UNKNOWN][ISS]
    receptor binding [TAS]
    patched binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLLLARCFL VALASSLLVC PGLACGPGRG FGKRQHPKKL TPLAYKQFIP NVAEKTLGAS  60
   61 GRYEGKITRN SERFKELTPN YNPDIIFKDE ENTGADRLMT QRCKDKLNAL AISVMNQWPG 120
  121 VKLRVTEGWD EDGHHSEESL HYEGRAVDIT TSDRDRSKYG MLARLAVEAG FDWVYYESKA 180
  181 RIHCSVKAEN SVAAKSDGCF PGSATVHLEQ GGTKLVKDLS PGDRVLAADD QGRLLYSDFL 240
  241 TFLDRDEGAK KVFYVIETRE PRERLLLTAA HLLFVAPHND SGPTPGPSPL FASRVRPGQR 300
  301 VYVVAERGGD RRLLPAAVHS VTLREEAAGA YAPLTADGTI LINRVLASCY AVIEEHSWAH 360
  361 RAFAPFRLAH ALLAALAPAR TDGGGGGSIP APQSVAEARG AGPPAGIHWY SQLLYHIGTW 420
  421 LLDSETLHPL GMAVKSS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle