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A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part. The process by which a fluid solution, or part of it, changes into a solid or semisolid mass. Any biological process, occurring at the level of a multicellular organism, pertinent to its function. Any process that modulates the frequency, rate or extent of blood coagulation. The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. Any process that activates or increases the frequency, rate or extent of blood coagulation. A pathway of blood coagulation that occurs during the clotting of platelet-poor plasma, in which activation of factor X to factor Xa is effected by the combination of factor IXa + factor VIIIa + calcium ion + phospholipid. Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation. The series of events that restore integrity to a damaged tissue, following an injury. A pathway of blood coagulation in which the earlier stages of the cascade are bypassed and the activation of factor X to factor Xa is effected by the combination of factor VIIa + thromboplastin; this second pathway occurs when tissue extracts are present in optimal amounts and is much more rapid than the intrinsic pathway. Any process that modulates the levels of body fluids.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: blood coagulation
Acc: GO:0007596
Aspect: Biological Process
Desc: The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
Synonyms:
  • blood clotting
Proteins in PDR annotated with:
   This term: 477 [Search]
   Term or descendants: 553 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0007596 - blood coagulation (interactive image map)
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