General Information: |
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Name(s) found: |
JAK2_RAT
[Swiss-Prot]
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Description(s) found:
SHOW ONLY BEST |
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Organism: | Rattus norvegicus |
Length: | 1132 amino acids |
Gene Ontology: |
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Cellular Component: |
membrane fraction
[IDA]
nucleus [UNKNOWN][IDA][ISS] caveola [UNKNOWN][IEA] cytoskeleton [IEA] cytoplasm [UNKNOWN][IDA] membrane [IEA] membrane raft [UNKNOWN] cytosol [IDA] endomembrane system [IEA] nuclear matrix [IDA] |
Biological Process: |
chromatin modification
[IEA]
peptidyl-tyrosine phosphorylation [UNKNOWN] activation of JAK2 kinase activity [UNKNOWN][ISS] positive regulation of phosphoinositide 3-kinase cascade [IEA] negative regulation of cell-cell adhesion [IMP] protein amino acid autophosphorylation [UNKNOWN][IMP][ISS] positive regulation of DNA binding [IMP] positive regulation of transcription factor activity [IMP] JAK-STAT cascade [UNKNOWN][IDA] hormone-mediated signaling pathway [IDA] activation of MAPKK activity [IMP] negative regulation of DNA binding [UNKNOWN][IEA] apoptosis [UNKNOWN] mineralocorticoid receptor signaling pathway [IMP] tyrosine phosphorylation of Stat3 protein [IMP] tyrosine phosphorylation of STAT protein [UNKNOWN] JAK-STAT cascade involved in growth hormone signaling pathway [UNKNOWN][ISS] positive regulation of growth hormone receptor signaling pathway [IEA] G-protein coupled receptor protein signaling pathway [IMP] tyrosine phosphorylation of Stat1 protein [IMP] STAT protein nuclear translocation [UNKNOWN][IEA] positive regulation of inflammatory response [IMP] induction of apoptosis by oxidative stress [IMP] platelet-derived growth factor receptor signaling pathway [IMP] erythrocyte differentiation [ISS] positive regulation of phosphoprotein phosphatase activity [IMP] myeloid cell differentiation [UNKNOWN] axon regeneration [IMP] positive regulation of cell migration [IMP] neuroprotection [IMP] positive regulation of protein import into nucleus, translocation [IMP] positive regulation of nitric oxide biosynthetic process [IMP] positive regulation of tyrosine phosphorylation of Stat3 protein [IEA] negative regulation of cell proliferation [UNKNOWN][IEA] positive regulation of cell proliferation [IMP] response to antibiotic [UNKNOWN][IEA] negative regulation of heart contraction [IMP] response to oxidative stress [IMP] cytokine-mediated signaling pathway [ISS] positive regulation of insulin secretion [IMP] positive regulation of peptidyl-tyrosine phosphorylation [IEA] response to hydroperoxide [IMP] signal transduction [ISS] intracellular protein kinase cascade [UNKNOWN] positive regulation of cell differentiation [IMP] enzyme linked receptor protein signaling pathway [UNKNOWN][IEA] positive regulation of tyrosine phosphorylation of Stat5 protein [IEA] elevation of cytosolic calcium ion concentration [IMP] positive regulation of apoptosis [IMP] cell differentiation [UNKNOWN] positive regulation of cell activation [IMP] positive regulation of interleukin-1 beta production [IMP] |
Molecular Function: |
phosphoinositide 3-kinase binding
[IPI]
acetylcholine receptor binding [IPI] interleukin-12 receptor binding [UNKNOWN][IEA] growth hormone receptor binding [IPI] SH2 domain binding [UNKNOWN][IEA] receptor binding [UNKNOWN] nucleotide binding [IEA] ATP binding [IEA] protein tyrosine kinase activity [UNKNOWN] protein binding [UNKNOWN] non-membrane spanning protein tyrosine kinase activity [IEA] histone binding [UNKNOWN][ISS] insulin receptor substrate binding [IPI] Janus kinase activity [UNKNOWN][IMP][ISS] peptide hormone receptor binding [IPI] transferase activity [IEA] histone kinase activity (H3-Y41 specific) [UNKNOWN] |
Sequence: |
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Sequence: [PDR BLAST] [ProtParam] |
1 11 21 31 41 51 | | | | | | 1 MGMACLTMTE MEGTSTSPAH QNGDIPGNAN SVKQTEPVLQ VYLYHSLGQA EGDYLKFPNG 60 61 EYVAEEICVA ASKACGITPV YHNMFALMSE TERIWYPPNH VFHIDESTRH NILYRIRFYF 120 121 PHWYCSGSNR TYRYGVSRGA EAPLLDDFVM SYLFAQWRHD FVHGWIKVPV THETQEECLG 180 181 MAVLDMMRIA KEKDQTPLAV YNSISYKTFL PKCVRAKIQD YHILTRKRIR YRFRRFIQQF 240 241 SQCKATARNL KLKYLINLET LQSAFYTEQF EVKESARGPS GEEIFATIII TGNGGIQWSR 300 301 GKHKESETLT EQDLQLYCDF PDIIDVSIKQ ANQECSTESR VVTVHKQDGK VLEIELSSLK 360 361 EALSFVSLID GYYRLTADAH HYLCKEVAPP AVLENIHSNC HGPISMDFAI SKLKKAGNQT 420 421 GLYVLRCSPK DFNKYFLTFA VERENVIEYK HCLITKNENG EYNLSGTKRN FSSLKDLLNC 480 481 YQMETVRSDS IIFQFTKCCP PKPKDKSNLL VFRTNGVSDV QLSPTLQRHN NVNQMVFHKI 540 541 RNEDLIFNES LGQGTFTKIF KGVRREVGDY GQLHETEVLL KVLDKAHRNY SESFFEAASM 600 601 MSQLSHKHLV LNYGVCVCGE ENILVQEFVK FGSLDTYLKK NKNSINILWK LGVAKQLAWA 660 661 MHFLEEKSLI HGNVCAKNIL LIREEDRKTG NPPFIKLSDP GISITVLPKD ILQERIPWVP 720 721 PECIENPKNL TLATDKWSFG TTLWEICSGG DKPLSALDSQ RKLQFYEDKH QLPAPKWTEL 780 781 ANLINTCMDY EPDFRPAFRA VIRDLNSLFT PDYELLTEND MLPNMRIGAL GFSGAFEDRD 840 841 PTQFEERHLK FLQQLGKGNF GSVEMCRYDP LQDNTGEVVA VKKLQHSTEE HLRDFEREIE 900 901 ILKSLQHDNI VKYKGVCYSA GRRNLRLIME YLPYGSLRDY LQKHKERIDH KKLLQYTSQI 960 961 CKGMEYLGTK RYIHRDLATR NILVENENRV KIGDFGLTKV LPQDKEYYKV KEPGESPIFW1020 1021 YAPESLTESK FSVASDVWSF GVVLYELFTY IEKSKSPPVE FMRMIGNDKQ GQMIVFHLIE1080 1081 LLKNNGRLPR PEGCPDEIYV IMTECWNNNV NQRPSFRDLS LRVDQIRDSM AA |
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Protein predicted to be: | GLOBULAR (No transmembrane regions or signal peptide) |
Confidence of classification: | 0.97 |
Source: Reynolds et al. (2008)