Protein Overview: JAK2_RAT

General Information:
Name(s) found:	JAK2_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|595683\|gb\|AAA79911.1\| protein tyrosine kinase [NCBI NR] gi\|2499669\|sp\|Q62689.1\|JAK2_RAT RecName: Full=Tyrosine-protein kinase JAK2; AltName: Full=Janus kinase 2; Short=JAK-2 [NCBI NR] gi\|149062664\|gb\|EDM13087.1\| Janus kinase 2, isoform CRA_b [Rattus norvegicus] [NCBI NR] gi\|13928696\|ref\|NP_113702.1\| Janus kinase 2 [Rattus norvegicus] [NCBI NR] pir\|\|JC4127 protein-tyrosine kinase (EC 2.7.1.112) - rat [NCBI NR] Tyrosine-protein kinase JAK2 OS=Rattus norvegicus GN=Jak2 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):1-229123107 Tyrosine-protein kinase JAK2 [hmr_yeast5_DM3-1_pombe.fasta] Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase) [HMR_022704-rand.fasta] Janus kinase 2 [Rattus norvegicus]gi\|2499669\|sp\|Q62689\|JAK2_RAT Tyrosine-protein kinase JAK2 (Janus kinase 2) (JAK-2)gi\|1085581\|pir\|\|JC4127 protein-tyrosine kinase (EC 2.7.1.112) - ratgi\|595683\|gb\|AAA79911.1\| protein tyrosine kinase [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Tyrosine-protein kinase JAK2 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_031514) janus kinase 2 (a protein tyrosine kinase) [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Janus kinase 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tyrosine-protein kinase JAK2 (Janus kinase 2) (JAK-2) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Janus kinase 2, isoform CRA_b [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] protein tyrosine kinase [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 TYROSINE-PROTEIN KINASE JAK2 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Jak2 Tyrosine-protein kinase JAK2 [rat-ipi-250309-contam.fasta] Tyrosine-protein kinase JAK2 OS=Rattus norvegicus GN=Jak2 [011711_HMR.fasta] Tyrosine-protein kinase JAK2 OS=Rattus norvegicus GN=Jak2 PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
Organism:	Rattus norvegicus
Length:	1132 amino acids
Gene Ontology:
Cellular Component:	membrane fraction [IDA] nucleus [UNKNOWN][IDA][ISS] caveola [UNKNOWN][IEA] cytoskeleton [IEA] cytoplasm [UNKNOWN][IDA] membrane [IEA] membrane raft [UNKNOWN] cytosol [IDA] endomembrane system [IEA] nuclear matrix [IDA]
Biological Process:	chromatin modification [IEA] peptidyl-tyrosine phosphorylation [UNKNOWN] activation of JAK2 kinase activity [UNKNOWN][ISS] positive regulation of phosphoinositide 3-kinase cascade [IEA] negative regulation of cell-cell adhesion [IMP] protein amino acid autophosphorylation [UNKNOWN][IMP][ISS] positive regulation of DNA binding [IMP] positive regulation of transcription factor activity [IMP] JAK-STAT cascade [UNKNOWN][IDA] hormone-mediated signaling pathway [IDA] activation of MAPKK activity [IMP] negative regulation of DNA binding [UNKNOWN][IEA] apoptosis [UNKNOWN] mineralocorticoid receptor signaling pathway [IMP] tyrosine phosphorylation of Stat3 protein [IMP] tyrosine phosphorylation of STAT protein [UNKNOWN] JAK-STAT cascade involved in growth hormone signaling pathway [UNKNOWN][ISS] positive regulation of growth hormone receptor signaling pathway [IEA] G-protein coupled receptor protein signaling pathway [IMP] tyrosine phosphorylation of Stat1 protein [IMP] STAT protein nuclear translocation [UNKNOWN][IEA] positive regulation of inflammatory response [IMP] induction of apoptosis by oxidative stress [IMP] platelet-derived growth factor receptor signaling pathway [IMP] erythrocyte differentiation [ISS] positive regulation of phosphoprotein phosphatase activity [IMP] myeloid cell differentiation [UNKNOWN] axon regeneration [IMP] positive regulation of cell migration [IMP] neuroprotection [IMP] positive regulation of protein import into nucleus, translocation [IMP] positive regulation of nitric oxide biosynthetic process [IMP] positive regulation of tyrosine phosphorylation of Stat3 protein [IEA] negative regulation of cell proliferation [UNKNOWN][IEA] positive regulation of cell proliferation [IMP] response to antibiotic [UNKNOWN][IEA] negative regulation of heart contraction [IMP] response to oxidative stress [IMP] cytokine-mediated signaling pathway [ISS] positive regulation of insulin secretion [IMP] positive regulation of peptidyl-tyrosine phosphorylation [IEA] response to hydroperoxide [IMP] signal transduction [ISS] intracellular protein kinase cascade [UNKNOWN] positive regulation of cell differentiation [IMP] enzyme linked receptor protein signaling pathway [UNKNOWN][IEA] positive regulation of tyrosine phosphorylation of Stat5 protein [IEA] elevation of cytosolic calcium ion concentration [IMP] positive regulation of apoptosis [IMP] cell differentiation [UNKNOWN] positive regulation of cell activation [IMP] positive regulation of interleukin-1 beta production [IMP]
Molecular Function:	phosphoinositide 3-kinase binding [IPI] acetylcholine receptor binding [IPI] interleukin-12 receptor binding [UNKNOWN][IEA] growth hormone receptor binding [IPI] SH2 domain binding [UNKNOWN][IEA] receptor binding [UNKNOWN] nucleotide binding [IEA] ATP binding [IEA] protein tyrosine kinase activity [UNKNOWN] protein binding [UNKNOWN] non-membrane spanning protein tyrosine kinase activity [IEA] histone binding [UNKNOWN][ISS] insulin receptor substrate binding [IPI] Janus kinase activity [UNKNOWN][IMP][ISS] peptide hormone receptor binding [IPI] transferase activity [IEA] histone kinase activity (H3-Y41 specific) [UNKNOWN]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
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    1 MGMACLTMTE MEGTSTSPAH QNGDIPGNAN SVKQTEPVLQ VYLYHSLGQA EGDYLKFPNG  60
   61 EYVAEEICVA ASKACGITPV YHNMFALMSE TERIWYPPNH VFHIDESTRH NILYRIRFYF 120
  121 PHWYCSGSNR TYRYGVSRGA EAPLLDDFVM SYLFAQWRHD FVHGWIKVPV THETQEECLG 180
  181 MAVLDMMRIA KEKDQTPLAV YNSISYKTFL PKCVRAKIQD YHILTRKRIR YRFRRFIQQF 240
  241 SQCKATARNL KLKYLINLET LQSAFYTEQF EVKESARGPS GEEIFATIII TGNGGIQWSR 300
  301 GKHKESETLT EQDLQLYCDF PDIIDVSIKQ ANQECSTESR VVTVHKQDGK VLEIELSSLK 360
  361 EALSFVSLID GYYRLTADAH HYLCKEVAPP AVLENIHSNC HGPISMDFAI SKLKKAGNQT 420
  421 GLYVLRCSPK DFNKYFLTFA VERENVIEYK HCLITKNENG EYNLSGTKRN FSSLKDLLNC 480
  481 YQMETVRSDS IIFQFTKCCP PKPKDKSNLL VFRTNGVSDV QLSPTLQRHN NVNQMVFHKI 540
  541 RNEDLIFNES LGQGTFTKIF KGVRREVGDY GQLHETEVLL KVLDKAHRNY SESFFEAASM 600
  601 MSQLSHKHLV LNYGVCVCGE ENILVQEFVK FGSLDTYLKK NKNSINILWK LGVAKQLAWA 660
  661 MHFLEEKSLI HGNVCAKNIL LIREEDRKTG NPPFIKLSDP GISITVLPKD ILQERIPWVP 720
  721 PECIENPKNL TLATDKWSFG TTLWEICSGG DKPLSALDSQ RKLQFYEDKH QLPAPKWTEL 780
  781 ANLINTCMDY EPDFRPAFRA VIRDLNSLFT PDYELLTEND MLPNMRIGAL GFSGAFEDRD 840
  841 PTQFEERHLK FLQQLGKGNF GSVEMCRYDP LQDNTGEVVA VKKLQHSTEE HLRDFEREIE 900
  901 ILKSLQHDNI VKYKGVCYSA GRRNLRLIME YLPYGSLRDY LQKHKERIDH KKLLQYTSQI 960
  961 CKGMEYLGTK RYIHRDLATR NILVENENRV KIGDFGLTKV LPQDKEYYKV KEPGESPIFW1020
 1021 YAPESLTESK FSVASDVWSF GVVLYELFTY IEKSKSPPVE FMRMIGNDKQ GQMIVFHLIE1080
 1081 LLKNNGRLPR PEGCPDEIYV IMTECWNNNV NQRPSFRDLS LRVDQIRDSM AA

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Protein Overview: JAK2_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: