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Protein Overview: ABCB4

General Information:
Name(s) found: ABCB4 [HGNC (HUGO)]
Description(s) found:
Found 34 descriptions.
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  • ATP-binding cassette, sub-family B (MDR/TAP), member 4 [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 1279 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLEAAKNGT AWRPTSAEGD FELGISSKQK RKKTKTVKMI GVLTLFRYSD WQDKLFMSLG  60
   61 TIMAIAHGSG LPLMMIVFGE MTDKFVDTAG NFSFPVNFSL SLLNPGKILE EEMTRYAYYY 120
  121 SGLGAGVLVA AYIQVSFWTL AAGRQIRKIR QKFFHAILRQ EIGWFDINDT TELNTRLTDD 180
  181 ISKISEGIGD KVGMFFQAVA TFFAGFIVGF IRGWKLTLVI MAISPILGLS AAVWAKILSA 240
  241 FSDKELAAYA KAGAVAEEAL GAIRTVIAFG GQNKELERYQ KHLENAKEIG IKKAISANIS 300
  301 MGIAFLLIYA SYALAFWYGS TLVISKEYTI GNAMTVFFSI LIGAFSVGQA APCIDAFANA 360
  361 RGAAYVIFDI IDNNPKIDSF SERGHKPDSI KGNLEFNDVH FSYPSRANVK ILKGLNLKVQ 420
  421 SGQTVALVGS SGCGKSTTVQ LIQRLYDPDE GTINIDGQDI RNFNVNYLRE IIGVVSQEPV 480
  481 LFSTTIAENI CYGRGNVTMD EIKKAVKEAN AYEFIMKLPQ KFDTLVGERG AQLSGGQKQR 540
  541 IAIARALVRN PKILLLDEAT SALDTESEAE VQAALDKARE GRTTIVIAHR LSTVRNADVI 600
  601 AGFEDGVIVE QGSHSELMKK EGVYFKLVNM QTSGSQIQSE EFELNDEKAA TRMAPNGWKS 660
  661 RLFRHSTQKN LKNSQMCQKS LDVETDGLEA NVPPVSFLKV LKLNKTEWPY FVVGTVCAIA 720
  721 NGGLQPAFSV IFSEIIAIFG PGDDAVKQQK CNIFSLIFLF LGIISFFTFF LQGFTFGKAG 780
  781 EILTRRLRSM AFKAMLRQDM SWFDDHKNST GALSTRLATD AAQVQGATGT RLALIAQNIA 840
  841 NLGTGIIISF IYGWQLTLLL LAVVPIIAVS GIVEMKLLAG NAKRDKKELE AAGKIATEAI 900
  901 ENIRTVVSLT QERKFESMYV EKLYGPYRNS VQKAHIYGIT FSISQAFMYF SYAGCFRFGA 960
  961 YLIVNGHMRF RDVILVFSAI VFGAVALGHA SSFAPDYAKA KLSAAHLFML FERQPLIDSY1020
 1021 SEEGLKPDKF EGNITFNEVV FNYPTRANVP VLQGLSLEVK KGQTLALVGS SGCGKSTVVQ1080
 1081 LLERFYDPLA GTVLLDGQEA KKLNVQWLRA QLGIVSQEPI LFDCSIAENI AYGDNSRVVS1140
 1141 QDEIVSAAKA ANIHPFIETL PHKYETRVGD KGTQLSGGQK QRIAIARALI RQPQILLLDE1200
 1201 ATSALDTESE KVVQEALDKA REGRTCIVIA HRLSTIQNAD LIVVFQNGRV KEHGTHQQLL1260
 1261 AQKGIYFSMV SVQAGTQNL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..633] PSI-BLAST 139.0 No description for 2hydA was found.
    2 View Details [634..1031] FFAS03 4.4 No description for 2hydA was found.
    3 View Details [1032..1279] PSI-BLAST 77.69897 Haemolysin B ATP-binding protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleotide binding
    		•  2.62374702628143 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  6.58863529263644 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  6.58067278719409 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  6.57974651657836 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  6.57922174989907 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  6.57807080367604 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  6.48406410175216 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  6.48154954364331 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  6.40467109535527 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  6.40151534181487 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  6.38373914253885 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  6.38247436082206 bayes_pls_golite062009
  • ATPase activity
    		•  6.30019941712404 bayes_pls_golite062009
  • peptide transporter activity
    		•  4.7442815698413 bayes_pls_golite062009
  • anion transmembrane-transporting ATPase activity
    		•  4.71935767060308 bayes_pls_golite062009
  • peptide-transporting ATPase activity
    		•  4.63590351019108 bayes_pls_golite062009
  • hydrolase activity
    		•  4.60957912556603 bayes_pls_golite062009
  • oligopeptide-transporting ATPase activity
    		•  4.09365342567844 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  3.57926427233638 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.4837867129694 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  3.40690615950081 bayes_pls_golite062009
  • ribonucleotide binding
    		•  3.40594996232845 bayes_pls_golite062009
  • purine nucleotide binding
    		•  3.3669118613715 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  3.35436118751376 bayes_pls_golite062009
  • nucleotide binding
    		•  3.33248266870364 bayes_pls_golite062009
  • phosphate transmembrane-transporting ATPase activity
    		•  3.20894563245332 bayes_pls_golite062009
  • ATP binding
    		•  3.17398570826788 bayes_pls_golite062009
  • inorganic anion transmembrane transporter activity
    		•  3.16975154423199 bayes_pls_golite062009
  • lipid transporter activity
    		•  3.14635082108971 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  3.13913638619234 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  3.12628113185041 bayes_pls_golite062009
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  3.08390071341252 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  3.0710107594224 bayes_pls_golite062009
  • iron ion transmembrane transporter activity
    		•  3.05511942104215 bayes_pls_golite062009
  • drug transmembrane transporter activity
    		•  2.97119034312001 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.88476360771975 bayes_pls_golite062009
  • amine-transporting ATPase activity
    		•  2.69529191205818 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  2.67957846350199 bayes_pls_golite062009
  • carboxylic acid transmembrane transporter activity
    		•  2.67815672695824 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  2.61311581579476 bayes_pls_golite062009
  • sterol transporter activity
    		•  2.48473697371886 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.40292717311506 bayes_pls_golite062009
  • canalicular bile acid transmembrane transporter activity
    		•  2.33958437214304 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  2.29486577878686 bayes_pls_golite062009
    		• 2.20174656498665 bayes_pls_golite062009
  • phosphate transmembrane transporter activity
    		•  2.15147988861177 bayes_pls_golite062009
  • binding
    		•  2.0681607836408 bayes_pls_golite062009
  • oligopeptide transporter activity
    		•  2.05580564974083 bayes_pls_golite062009
  • L-aspartate transmembrane transporter activity
    		•  2.05274761921715 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.91091452720653 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  1.82177108193332 bayes_pls_golite062009
  • organic anion transmembrane transporter activity
    		•  1.76999970080179 bayes_pls_golite062009
  • protein transporter activity
    		•  1.71214667007262 bayes_pls_golite062009
  • amino acid transmembrane transporter activity
    		•  1.59627719545436 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.58971273330352 bayes_pls_golite062009
  • phosphonate transmembrane transporter activity
    		•  1.40269234722336 bayes_pls_golite062009
  • monocarboxylic acid transmembrane transporter activity
    		•  1.37836402136387 bayes_pls_golite062009
  • cation channel activity
    		•  1.33585529285301 bayes_pls_golite062009
  • molybdate transmembrane-transporting ATPase activity
    		•  1.28313088935613 bayes_pls_golite062009
  • molybdate ion transmembrane transporter activity
    		•  1.28313088935613 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  1.23799860254751 bayes_pls_golite062009
  • potassium channel activity
    		•  1.17288958041707 bayes_pls_golite062009
  • sulfate transmembrane-transporting ATPase activity
    		•  1.1220946941463 bayes_pls_golite062009
  • dipeptide transporter activity
    		•  1.01130176523309 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  1.00384984515681 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.889208591820696 bayes_pls_golite062009
  • motor activity
    		•  0.87979065815418 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.871525745291603 bayes_pls_golite062009
    		• 0.869999622006359 bayes_pls_golite062009
  • ion channel activity
    		•  0.848261056209476 bayes_pls_golite062009
  • GTPase activity
    		•  0.83849854735032 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.806331380134838 bayes_pls_golite062009
  • channel activity
    		•  0.806331380134838 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.799997700906738 bayes_pls_golite062009
  • copper ion transmembrane transporter activity
    		•  0.798934081014025 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.767424210804186 bayes_pls_golite062009
  • bile acid transmembrane transporter activity
    		•  0.687612064139871 bayes_pls_golite062009
  • gated channel activity
    		•  0.650050847753837 bayes_pls_golite062009
  • cholesterol transporter activity
    		•  0.644421039250979 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.640772201693186 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.63468044350616 bayes_pls_golite062009
  • GTP binding
    		•  0.621689261700018 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  0.46552249844591 bayes_pls_golite062009
  • branched-chain aliphatic amino acid transmembrane transporter activity
    		•  0.442220326523999 bayes_pls_golite062009
  • neutral amino acid transmembrane transporter activity
    		•  0.227570438294493 bayes_pls_golite062009
  • signal recognition particle binding
    		•  0.20866768220789 bayes_pls_golite062009
  • protein binding
    		•  0.193768631623192 bayes_pls_golite062009
  • amino acid-transporting ATPase activity
    		•  0.147644650870465 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.144904409289829 bayes_pls_golite062009
  • microtubule motor activity
    		•  0.11674780318211 bayes_pls_golite062009
  • sulfate transmembrane transporter activity
    		•  0.104477131120205 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  0.0536898657672154 bayes_pls_golite062009
  • macromolecule transmembrane transporter activity
    		•  0.00571427458217011 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity
    		•  0.00571427458217011 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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