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Protein Overview: ISA2

General Information:
Name(s) found: ISA2 / YPR067W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Protein required for maturation of mitochondrial and cytosolic Fe/S proteins, localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 185 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial intermembrane space [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    Biological Process: iron ion transport [IGILink to PubMed article][ISSLink to PubMed article]
    response to drug [IMPLink to PubMed article]
    biotin biosynthetic process [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQAKLLFTRL NFRRPSTTLR QFPLTCFLFH SKAFYSDLVT KEPLITPKRI INKTPGLNLS  60
   61 ISERASNRLA EIYRNSKENL RISVESGGCH GFQYNLTLEP ATKPDIKNDV KDKEFSDDLD 120
  121 DDDSKDIIYV LPEDKGRVII DSKSLNILNN TTLTYTNELI GSSFKIINGS LKSSCGCGSS 180
  181 FDIEN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ISA2 PUF4 RPL11B RPL12B, RPL12A RPL16A RPL17A RPL17B RPL18A, RPL18B RPL20A RPL21A RPL23B, RPL23A RPL29 RPL2A, RPL2B RPL3 RPL32 RPL36A RPL42B, RPL42A RPL4A RPL6A RPL9A RPS14A RPS17B RPS22A RPS3 RPS30B, RPS30A RPS5 YHI9
    View Details Krogan NJ, et al. (2006) GLO3 ISA2 KEX1 LYS20 RPL37B YBL086C
    View Details Ho Y, et al. (2002) ACC1 ACH1 ADH2 ADR1 GCD11 GFA1 GND1 GUS1 IDH2 ISA2 MDH1 MET18 NGL2 PYC1 PYC2 RET1 RPA135 RPA190 RPA49 RPB5 RPC19 RPC25 RPC34 RPC40 RPC82 RPN3 RPO26 RPO31 RVS167 SEC27 TBS1 TFP1 TSA2 YFL042C YHR112C
    View Details Qiu et al. (2008) COX17 ISA2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ISA2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..185] PSI-BLAST 127.0103 Hypothetical protein Aq 1857

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  0.946497535495414 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.538168598935332 bayes_pls_golite062009
  • iron ion binding
    		•  0.124887686699639 bayes_pls_golite062009
  • protein binding
    		•  0.095614303446809 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle