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View Structure Prediction Details

Protein: ISA2
Organism: Saccharomyces cerevisiae
Length: 185 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ISA2.

Description E-value Query
Range
Subject
Range
gi|190408003 - gi|190408003|gb|EDV11268.1| iron sulfur assembly protein 2 [Saccharomyces cerevisiae RM11-1a]
gi|207340354 - gi|207340354|gb|EDZ68730.1| YPR067Wp-like protein [Saccharomyces cerevisiae AWRI1631]
ISA2 - Protein required for maturation of mitochondrial and cytosolic Fe/S proteins, localizes to the mitoc...
ISA2_YEAST - Iron-sulfur assembly protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ISA2 PE=1...
1.0E-44 [1..185] [1..185]
gi|26987580, gi|... - gi|26987580|ref|NP_743005.1| iron-sulfur cluster assembly protein IscA [Pseudomonas putida KT2440], ...
gi|126317906, gi... - gi|167031902|ref|YP_001667133.1| iron-sulfur cluster assembly protein IscA [Pseudomonas putida GB-1]...
tr|E4R524|E4R524... - IscA OS=Pseudomonas putida (strain BIRD-1) GN=iscA PE=3 SV=1
tr|I7C0T3|I7C0T3... - Iron-sulfur cluster assembly protein IscA OS=Pseudomonas putida (strain DOT-T1E) GN=iscA PE=3 SV=1
gi|148510176, gi... - gi|82738432|ref|ZP_00901265.1| HesB/YadR/YfhF:Iron-sulphur cluster assembly protein IscA [Pseudomona...
1.0E-34 [57..183] [1..107]
gi|91209227, gi|... - gi|91209227|ref|YP_539213.1| iron-sulfur cluster insertion protein ErpA [Escherichia coli UTI89], gi...
gi|26246102, gi|... - gi|26246102|ref|NP_752141.1| iron-sulfur cluster insertion protein ErpA [Escherichia coli CFT073], g...
1.0E-34 [40..183] [1..125]
gi|126208405, gi... - gi|126208405|ref|YP_001053630.1| iron-binding protein IscA [Actinobacillus pleuropneumoniae L20], gi...
gi|190150256, gi... - gi|190150256|ref|YP_001968781.1| iron-binding protein IscA [Actinobacillus pleuropneumoniae serovar ...
gi|165976348, gi... - gi|165976348|ref|YP_001651941.1| iron-binding protein [Actinobacillus pleuropneumoniae serovar 3 str...
gi|32034039 - gi|32034039|ref|ZP_00134283.1| COG0316: Uncharacterized conserved protein [Actinobacillus pleuropneu...
1.0E-34 [57..183] [1..107]
gi|27360021, gi|... - gi|27363904|ref|NP_759432.1| HesB family protein [Vibrio vulnificus CMCP6], gi|27360021|gb|AAO08959....
2.0E-34 [57..183] [1..107]
ISCAP_ARATH - Iron-sulfur assembly protein IscA, chloroplastic OS=Arabidopsis thaliana GN=ISCA PE=2 SV=2
3.0E-34 [8..184] [14..179]
gi|22298410, gi|... - gi|22298410|ref|NP_681657.1| hypothetical protein tll0867 [Thermosynechococcus elongatus BP-1], gi|2...
4.0E-34 [53..182] [6..117]
gi|33148430, gi|... - gi|33152208|ref|NP_873561.1| hesB family protein [Haemophilus ducreyi 35000HP], gi|33148430|gb|AAP95...
4.0E-34 [57..183] [1..107]
gi|12720557, gi|... - gi|15602185|ref|NP_245257.1| hypothetical protein PM0320 [Pasteurella multocida subsp. multocida str...
5.0E-34 [57..183] [1..107]
gi|11279039 - pir||H81089 HesB/YadR/YfhF family protein NMB1381 [imported] - Neisseria meningitidis (strain MC58 s...
gi|15677244, gi|... - gi|7226622|gb|AAF41749.1| HesB/YadR/YfhF family protein [Neisseria meningitidis MC58], gi|15677244|r...
6.0E-34 [39..183] [3..126]

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Predicted Domain #1
Region A:
Residues: [1-185]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQAKLLFTRL NFRRPSTTLR QFPLTCFLFH SKAFYSDLVT KEPLITPKRI INKTPGLNLS  60
   61 ISERASNRLA EIYRNSKENL RISVESGGCH GFQYNLTLEP ATKPDIKNDV KDKEFSDDLD 120
  121 DDDSKDIIYV LPEDKGRVII DSKSLNILNN TTLTYTNELI GSSFKIINGS LKSSCGCGSS 180
  181 FDIEN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 127.0103
Match: 1nwbA_
Description: Hypothetical protein Aq 1857
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.946497535495414 bayes_pls_golite062009
transition metal ion binding 0.538168598935332 bayes_pls_golite062009
iron ion binding 0.124887686699639 bayes_pls_golite062009
protein binding 0.095614303446809 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle