YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: THI21

General Information:
Name(s) found: THI21 / YPL258C [SGD]
Description(s) found:
SHOW ONLY BEST
  • gi|6324997|ref|NP_015065.1| Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p; Thi21p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|59800402|sp|Q08975.1|THI21_YEAST RecName: Full=Phosphomethylpyrimidine kinase THI21; AltName: Full=HMP-phosphate kinase; Short=HMP-P kinase [NCBI NR]
  • pir||S65289 hypothetical protein YPL258c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1370532|emb|CAA97986.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21 OS=Saccharomyces cerevisiae GN=THI21 PE=1 SV=1 [Swiss-Prot]
  • THI21 Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis [mips]
  • Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; Thi20p also has this activity [SGD]
  • >Q08975 (Q08975) ORF YPL258C [4932.FASTACCERV.txt]
  • Chr XVI from 55153-53498, reverse complement [hmr_yeast5_DM3-1_pombe.fasta]
  • Chr XVI from 53498-55153, reverse complement [yeastorf3.fasta]
  • THI21, Chr XVI from 53498-55153, reverse complement [yeast_orfs2]
  • THI21 SGDID:S0006179, Chr XVI from 55153-53498, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p [Saccharomyces cerevisiae]gi|1370532|emb|CAA97986.1| unnamed protein product [ [nrdb_11152004_Chlamydomonas]
  • (Q08975) ORF YPL258c [cerv4932.FASTAC]
  • THI21 SGDID:S000006179, Chr XVI from 55153-53498, reverse complement, Verified ORF, "Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with T [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Phosphomethylpyrimidine kinase THI21 (HMP-phosphate kinase) (HMP-P kinase) [nr-271106-contam.fasta]
  • Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p; Thi21p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • THI21 SGDID:S000006179, Chr XVI from 55153-53498, reverse complement, Verified ORF, "Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; Thi20p also has this activity [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta]
  • THI21 SGDID:S000006179, Chr XVI from 55153-53498, reverse complement, Verified ORF, "Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • THI21 SGDID:S000006179, Chr XVI from 55153-53498, reverse complement, Verified ORF, "Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; Thi20p also has this activity" [SGDyeast.20101221.fasta]
  • Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=THI21 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • THI21 SGDID:S000006179, Chr XVI from 55153-53498, Genome Release 64-1-1, reverse complement, Verified ORF, "Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; Thi20p also has this activity" [yeast-030211-contam.fasta]
  • THI21 SGDID:S000006179, Chr XVI from 55153-53498, Genome Release 64-2-1, reverse complement, Verified ORF, "Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p" [20141208_orf_trans.fasta]
  • YPL258C SGDID:S000006179, Chr XVI from 55153-53498, Genome Release 64-1-1, reverse complement, Verified ORF, "Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; Thi20p also has this activity" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 551 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: thiamin biosynthetic process [IEPLink to PubMed article][IGILink to PubMed article]
    Molecular Function: hydroxymethylpyrimidine kinase activity [IDALink to PubMed article][IMPLink to PubMed article]
    phosphomethylpyrimidine kinase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTYSTVNINT PPPYLALASN EKLPTVLSIA GTDPSGGAGV EADVKTITAH RCYAMTCITA  60
   61 LNAQTPVKVY SINNTPKEVV SQILDANLQD MKCDVIKTGM LTTAAIEVLH EKLLQLGENR 120
  121 PKLVVDPVLV ATSGSSLAGK DIASLITEKI APFADILTPN IPECFKLLGE DREISKLRDI 180
  181 FEVAKDLAKI TKCSNILVKG GHIPWNDEEG KYITDVLYLG AEQRFITFKG NFVNTTHTHG 240
  241 TGCTLASAIA SNLARGYSLP QSVYGGIEYV QNAVAIGCDV TKETVKDNGP INHVYAIEIP 300
  301 LEKMLSDECF TASDAVHKKP VKSSLNKIPG GSFYKYLINH PKVKPHWDSY VNHDFVRKVA 360
  361 DGSLEPKKFQ FFIEQDYLYL VNYARISCIA GSKSPCLEDL EKELVIVECV RNGLCQHERR 420
  421 LREEFGIKDP DYLQKIQRGP ALRAYCRYFN DVSRRGNWQE LVIALNPCLM GYVHALTKIK 480
  481 DEVTAAEGSV YREWCETYSS SWCHEAMLEG EKLLNHILET YPPEKLDTLV TIYAEVCELE 540
  541 ANFWTAALEY E

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ATG18 BRX1 CCT6 CDC33 CDC53 CIC1 CPR6 EBP2 ERB1 EXG1 FMP10 FPR4 MDJ1 MRT4 MTC5 NOC3 NOG1 NOP15 NOP16 NOP2 NOP7 NPR2 PDC5 PDC6 PIB2 POX1 PPH21 PPH22 PRB1 RLP7 RNQ1 RRP17 SAF1 SAP155 SCS2 SEH1 SIT4 THI21 TIF6 TPD3 YCK1 YCK2 YHR033W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run YPI1 No Comments Hazbun TR, et al. (2003)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..319] PSI-BLAST 364.512579 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase (HMP-phosphate kinase, ThiD)
    2 View Details [320..551] Pfam 98.481486 TENA/THI-4/PQQC family No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphomethylpyrimidine kinase activity
    		•  3.972577109569 bayes_pls_golite062009
  • kinase activity
    		•  2.74755351135221 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.43969902311075 bayes_pls_golite062009
  • carbohydrate kinase activity
    		•  2.34445983129813 bayes_pls_golite062009
  • thiaminase activity
    		•  2.33383885490808 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.31951903725366 bayes_pls_golite062009
  • phosphotransferase activity, phosphate group as acceptor
    		•  2.29466565429735 bayes_pls_golite062009
  • transferase activity
    		•  2.15883296431019 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.14277879659132 bayes_pls_golite062009
  • DNA binding
    		•  1.96007866678724 bayes_pls_golite062009
  • catalytic activity
    		•  1.74474587246986 bayes_pls_golite062009
  • binding
    		•  1.4216897826135 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.37866801006693 bayes_pls_golite062009
  • hydroxyethylthiazole kinase activity
    		•  1.28568044601242 bayes_pls_golite062009
  • thiamin-phosphate diphosphorylase activity
    		•  1.27602595951972 bayes_pls_golite062009
  • transcription factor activity
    		•  1.22047633822494 bayes_pls_golite062009
  • phosphofructokinase activity
    		•  0.37205329607884 bayes_pls_golite062009
  • pyridoxal kinase activity
    		•  0.217863391052366 bayes_pls_golite062009
  • protein binding
    		•  0.117280046908929 bayes_pls_golite062009
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  2.47421036599568 bayes_pls_golite062009
  • binding
    		•  1.80342520508546 bayes_pls_golite062009
  • transcription activator activity
    		•  0.765671114434415 bayes_pls_golite062009
  • catalytic activity
    		•  0.476060647762462 bayes_pls_golite062009
  • protein binding
    		•  0.438212622992804 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle